Different miRNA signatures of oral and pharyngeal squamous cell carcinomas: a prospective translational study

Lajer, Christel; Nielsen, Finn Cilius; Friis‐Hansen, Lennart; Norrild, Bodil; Borup, Rehannah; Garnæs, Emilie; Rossing, Maria; Specht, Lena; Therkildsen, Marianne Hamilton; Nauntofte, Birgitte; Dabelsteen, Sally; Buchwald, Christian von

doi:10.1038/bjc.2011.29

Cited by 190 publications

(202 citation statements)

References 41 publications

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“…Gain-of-function experiments in lung cancer cell lines have shown that miRNA 125a-5p suppressed proliferation and induced apoptosis (15). In HNSCC, miRNA 125a-5p did not change (18) or was reduced regarding human papillomavirus (HPV)-positive tumors (19). In the present study, JA is shown to be one of numerous neoplasms that exhibit downregulated miRNA 125a-5p.…”

Section: Discussionmentioning

confidence: 67%

Preliminary analysis of different microRNA expression levels in juvenile angiofibromas

2014

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Abstract. Juvenile angiofibroma (JA) is a rare fibrovascular tumor affecting, almost exclusively, adolescent males. The finding of frequent β-catenin-mutations in JAs emphasized the significance of the Wnt-signaling pathway in tumor pathogenesis. In the last decade, microRNAs (miRNAs or miRs) have been found to be involved in cancer pathogenesis by post-transcriptional regulation of gene expression and have not been analyzed in JAs thus far. In the present study, the expression of 4 miRNAs (hsa-let-7d, hsa-miR-98, hsa-miR-125a-5p and hsa-miR-218) was analyzed in 13 JAs and 3 deepithelized inferior nasal turbinates that were used as control tissue. The miRNA expression of hsa-let-7d (P= 0.158) and hsa-miR-98 (P= 0.069) was not statistically different between the two tissue types, however, a significant decrease in expression was observed for hsa-miR-125a-5p (P= 0.037) and hsa-miR-218 (P= 0.009) in JAs compared to inferior nasal turbinates. As downregulation of miRNA 218 has been recently shown to result in stabilization and nuclear accumulation of β-catenin, the present data indicates further evidence for the importance of the Wnt-signaling pathway in JAs.

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Section: Discussionmentioning

confidence: 67%

Preliminary analysis of different microRNA expression levels in juvenile angiofibromas

2014

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“…The results varied, with many miRs proposed to correlate with tumor HPV status or outcome, with few miRs found common between studies. Mir-9, 155 and 163b were in several studies found overexpressed in HPV-positive vs. HPV-negative OPSCC, while miR-31 and 193b were downregulated (68)(69)(70)(71)73). Also, a 25 miR signature discriminating HPV-positive vs. HPV-negative OPSCC was suggested, but few of the indicated miRs were common with other studies (67).…”

Section: Microrna Expression In Oropharyngeal Cancer In Relation To Hmentioning

confidence: 91%

“…MicroRNA (miR) expression in OPSCC has been mainly analyzed in normal tissue, HPV-positive vs. HPV-negative tumor status and to a lesser extent to outcome (67)(68)(69)(70)(71)(72)(73). The results varied, with many miRs proposed to correlate with tumor HPV status or outcome, with few miRs found common between studies.…”

Section: Microrna Expression In Oropharyngeal Cancer In Relation To Hmentioning

confidence: 99%

Human Papillomavirus and Potentially Relevant Biomarkers in Tonsillar and Base of Tongue Squamous Cell Carcinoma

Näsman

Bersani

Lindquist

et al. 2017

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Abstract. Human papillomavirus (HPV)-positive tonsillarand base of tongue cancer is increasing epidemically and has much better outcome than corresponding HPV-negativeIn 2007, human papillomavirus (HPV) was recognized as a risk factor for oropharyngeal squamous cell carcinoma (OPSCC) by the International Agency for Research against Cancer (IARC), besides the traditional risk factors smoking and alcohol (1-4). Concurrently, an increased incidence of OPSCC, more specifically tonsillar and base of tongue cancer (TSCC and BOTSCC, the two main HPV-positive OPSCC sites) was described in many developed countries, and found to be due to a sharp rise of HPV-positive cases (5-18). These HPV-positive tumors had a much better clinical outcome than their HPV-negative counterparts and head and neck squamous cell carcinoma (HNSCC) in general when treated with radiotherapy and surgery (1-3, 15-17, 19, 20). Treatment of HNSCC including OPSCC has, however, gradually become more intensified with induction chemotherapy or concurrent chemo-radiotherapy and sometimes the administration of Erbitux, leading to more severe side effects (16, 20, 21). This is likely unnecessary for most HPV-positive TSCC and BOTSCC patients since they generally respond well to less therapy and furthermore, intensified therapy does not improve survival of [15][16][17] 20, 22, 23). It is, therefore, important to identify patients with HPV-positive TSCC and BOTSCC eligible for less treatment or targeted therapy and efforts focus now on finding predictive and targetable markers for these patients (24-39).Here, a short background of the field and an update on recent attempts to find predictive and targetable markers with different methodologies for individualized therapy is presented. Human Papillomavirus in Tonsillar and Base of Tongue Squamous Cell Carcinoma and an Epidemic Increase of these TumorsIn 2000, an association between HPV and OPSCC and TSCC was reported, and with radiotherapy and surgery, these HPVpositive cases had much better outcome than corresponding HPV-negative cases (80% vs. 40-50% 5-year survival) (1, 2). In 2004, a similar relationship of HPV to BOTSCC, but not to mobile tongue cancer was disclosed (40). Based on 5319

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“…In this review, we have listed nine miRNA expression signatures in HNSCC and ESCC. 12,13,15, [18][19][20][21][22][23] Differentially expressed miRNAs are summarized based on the nine signatures in Table 1. Recently, we conducted miRNA expression signature analyses in hypopharyngeal-SCC, maxillary sinus SCC and ESCC using clinical specimens.…”

Section: Aberrant Expression and Functional Significance Of Mir-375 Imentioning

confidence: 99%

“…16,17 Other research groups also showed downregulation of miR-375 in HNSCC and ESCC and other types of human cancers. [18][19][20][21][22][23][24][25][26][27][28][29][30][31] In this review, we focus on HNSCC and ESCC and describe the aberrant expression of miRNAs in these cancers and the cancer pathways they may regulate in these diseases.…”

Section: Introductionmentioning

confidence: 99%

The functional significance of microRNA-375 in human squamous cell carcinoma: aberrant expression and effects on cancer pathways

et al. 2012

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MicroRNAs (miRNAs) are a class of small, non-coding RNA molecules consisting of 19-22 nucleotides that are involved in a variety of biological processes, including development, differentiation, apoptosis and cell proliferation. In cancer research, a growing body of evidence has indicated that miRNAs are aberrantly expressed in many types of human cancers and can function either as tumor suppressors or oncogenes. Bioinformatic predictions suggest that miRNAs regulate more than 30% of protein-coding genes. Aberrant expression of miRNAs in cancer cells causes destruction of miRNA-regulated messenger RNA networks. Therefore, the identification of miRNA-regulated cancer pathways is important for understanding the molecular mechanisms of human cancer. Searching for the aberrant expression of miRNAs in cancer cells is the first step in the functional analysis of miRNAs in cancer cells. Genome-wide miRNA expression signatures can rapidly and precisely reveal aberrant expression of miRNA in cancers. The miRNA expression signatures of human cancers have revealed that miR-375 is significantly downregulated in cancer cells. Our recent data on maxillary sinus, hypopharyngeal and esophageal squamous cell carcinomas have suggested that miR-375 is frequently downregulated and functions as a tumor suppressor that targets several oncogenic genes in cancer cells. In this review, we focus on several types of human squamous cell carcinoma and describe the aberrant expression of miRNAs and the cancer pathways they regulate in these diseases.

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Different miRNA signatures of oral and pharyngeal squamous cell carcinomas: a prospective translational study

Cited by 190 publications

References 41 publications

Preliminary analysis of different microRNA expression levels in juvenile angiofibromas

Preliminary analysis of different microRNA expression levels in juvenile angiofibromas

Human Papillomavirus and Potentially Relevant Biomarkers in Tonsillar and Base of Tongue Squamous Cell Carcinoma

The functional significance of microRNA-375 in human squamous cell carcinoma: aberrant expression and effects on cancer pathways

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