Different Nanotechnology Approaches for Ciprofloxacin Delivery Against Multidrug-Resistant Microbes

Yayehrad, Ashagrachew Tewabe; Birhanu, Gebremariam; Marew, Tesfa

doi:10.2147/idr.s348643

Cited by 28 publications

(19 citation statements)

References 80 publications

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“…It's noteworthy to mention that, other studies that have used of nanoplatforms for enhancement of ciprofloxacin efficacy are presented in Table 4 . Based on this table and mentioned studies, ciprofloxacin delivery can be modified by encapsulating with or incorporating different polymeric NPs such as poly lactic-co-glycolic acid (PLGA), chitosan, arginine, albumin, and other organic and inorganic nanostructure systems ( 179 ). Furthermore, studies have also shown that nano-platforms could enhance the efficiency of ciprofloxacin against bacterial cells, interfere with the biofilm community, enhance the penetration and protect the drug from deactivation or efflux ( Figure 4 ).…”

Section: The Combine Use Of Ciprofloxacin With Different Antibacteria...mentioning

confidence: 99%

The resistance mechanisms of bacteria against ciprofloxacin and new approaches for enhancing the efficacy of this antibiotic

Shariati

Arshadi

Khosrojerdi

et al. 2022

Front. Public Health

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For around three decades, the fluoroquinolone (FQ) antibiotic ciprofloxacin has been used to treat a range of diseases, including chronic otorrhea, endocarditis, lower respiratory tract, gastrointestinal, skin and soft tissue, and urinary tract infections. Ciprofloxacin's main mode of action is to stop DNA replication by blocking the A subunit of DNA gyrase and having an extra impact on the substances in cell walls. Available in intravenous and oral formulations, ciprofloxacin reaches therapeutic concentrations in the majority of tissues and bodily fluids with a low possibility for side effects. Despite the outstanding qualities of this antibiotic, Salmonella typhi, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa have all shown an increase in ciprofloxacin resistance over time. The rise of infections that are resistant to ciprofloxacin shows that new pharmacological synergisms and derivatives are required. To this end, ciprofloxacin may be more effective against the biofilm community of microorganisms and multi-drug resistant isolates when combined with a variety of antibacterial agents, such as antibiotics from various classes, nanoparticles, natural products, bacteriophages, and photodynamic therapy. This review focuses on the resistance mechanisms of bacteria against ciprofloxacin and new approaches for enhancing its efficacy.

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Section: The Combine Use Of Ciprofloxacin With Different Antibacteria...mentioning

confidence: 99%

The resistance mechanisms of bacteria against ciprofloxacin and new approaches for enhancing the efficacy of this antibiotic

Shariati

Arshadi

Khosrojerdi

et al. 2022

Front. Public Health

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show abstract

“…Researchers have developed different strategies to improve the therapeutic effectiveness of cipro oxacin and overcome the resistance issue, of them, targeting cipro oxacin more precisely to the site of infection by using carriers. Cipro oxacin-nanoparticles conjugation, cipro oxacin nanoencapsulation, loading cipro oxacin in liposomes, and polymeric nanoformations are among the different promising nanotechnology-based approaches to combat cipro oxacin resistance [50]. In conclusion, isolates of Genus Enterobacter sp.…”

Section: Discussionmentioning

confidence: 99%

Isolation, characterization, and antibiotic sensitivity pattern of Gram-negative bacteria causing chronic bacterial prostatitis

Mehanni

Sayed

El-Gendy

et al. 2022

Preprint

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Background: Bacterial prostatitis (BP) is an infection of the prostate gland, it can be acute (ABP) or chronic (CBP) and if not treated appropriately, it can result in significant morbidity.Results: In this study, expressed prostate secretion from 10 patients that are diagnosed with chronic bacterial prostatitis at Ain-Shams hospital, Egypt are used to isolate the common causative bacteria for CBP. Results of this study indicated that Gram negative bacteria were predominant since 54 Gram-ve bacterial isolates were obtained out of the total 62 isolates. Gram-ve bacterial isolates were grouped according to their oxidase test results and to lactose fermentation capability into three groups. The largest group contained 38 isolates of oxidase negative, lactose fermenters. Five representative isolates of this group were identified biochemically or by 16S rRNA sequence homology to be related to Enterobacter cloacae complex (3 Enterobacter cloacae related strains and 2 Enterobacter kobei related strains). Oxidase positive lactose non-fermentors group contained 9 isolates while oxidase negative lactose non-fermentors group contained 7 isolates. A representative isolate for each of them were identified by 16S rRNA sequence homology to be a strain of Pseudomonas stutzeri and Providencia stuartii respectively. Antibiotic sensitivity pattern of the chosen representative isolates indicated that all of them were sensitive to ciprofloxacin followed by ampicillin while resistance to cefaclor and aztereonam was prevalent. Other tested antibiotics recorded different sensitivity pattern among tested isolates.Conclusions: isolates of Genus Enterobacter sp. included in the E. cloacae complex group represent the most common bacterial pathogen in tested EPS of CBP diagnosed patients, of them Enterobacter cloacae was the most common.

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“…Ciprofloxacin (CIPRO), a small molecular drug, is a broad-spectrum antimicrobial carboxyfluoroquinoline agent with demonstrated activity against most strains of Gramnegative bacteria and against certain Gram-positive bacteria [28]. CIPRO proved a powerful antibiotic to be applied for bone infections [29]. CIPRO hydrochloride powder of 99.5% purity was purchased from Gen Hunter (Nashville, TN, USA).…”

Section: Methodsmentioning

confidence: 99%

Implant Surfaces Containing Bioglasses and Ciprofloxacin as Platforms for Bone Repair and Improved Resistance to Microbial Colonization

et al. 2022

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Coatings are an attractive and challenging selection for improving the bioperformance of metallic devices. Composite materials based on bioglass/antibiotic/polymer are herein proposed as multifunctional thin films for hard tissue implants. We deposited a thin layer of the polymeric material by matrix-assisted pulsed laser evaporation—MAPLE onto Ti substrates. A second layer consisting of bioglass+antibiotic was applied by MAPLE onto the initial thin film. The antimicrobial activity of MAPLE-deposited thin films was evaluated on Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa standard strains. The biocompatibility of obtained thin films was assessed on mouse osteoblast-like cells. The results of our study revealed that the laser-deposited coatings are biocompatible and resistant to microbial colonization and biofilm formation. Accordingly, they can be considered viable candidates for biomedical devices and contact surfaces that would otherwise be amenable to contact transmission.

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Different Nanotechnology Approaches for Ciprofloxacin Delivery Against Multidrug-Resistant Microbes

Cited by 28 publications

References 80 publications

The resistance mechanisms of bacteria against ciprofloxacin and new approaches for enhancing the efficacy of this antibiotic

The resistance mechanisms of bacteria against ciprofloxacin and new approaches for enhancing the efficacy of this antibiotic

Isolation, characterization, and antibiotic sensitivity pattern of Gram-negative bacteria causing chronic bacterial prostatitis

Implant Surfaces Containing Bioglasses and Ciprofloxacin as Platforms for Bone Repair and Improved Resistance to Microbial Colonization

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