“…We also showed that there is a simultaneous homing of ␥␦ T cells from the periphery to the MLNs and Payer's patches [8]. All these effects waned by day 7.…”
Section: Discussionsupporting
confidence: 53%
“…We previously showed in an animal model of partial gastrectomy that, within 3 d of surgery, there is an increased percentage of T␥␦ϩ cells in both the Peyer's patches and mesenteric lymph nodes (MLNs) as well as a parallel decrease in these cells in the peripheral blood [8]. We suggested that major surgical trauma may affect the normal cell traffic, selectively inducing the homing of T␥␦ϩ cell to lymphatic organs draining the gastrointestinal tract.…”
“…We also showed that there is a simultaneous homing of ␥␦ T cells from the periphery to the MLNs and Payer's patches [8]. All these effects waned by day 7.…”
Section: Discussionsupporting
confidence: 53%
“…We previously showed in an animal model of partial gastrectomy that, within 3 d of surgery, there is an increased percentage of T␥␦ϩ cells in both the Peyer's patches and mesenteric lymph nodes (MLNs) as well as a parallel decrease in these cells in the peripheral blood [8]. We suggested that major surgical trauma may affect the normal cell traffic, selectively inducing the homing of T␥␦ϩ cell to lymphatic organs draining the gastrointestinal tract.…”
“…Gryglewski et al [18] recently reported that GALT phenotype was altered in a murine model of major surgery (partial gastrectomy). These studies documented a significant postgastrectomy Day 3 increase in the percentage of TCR␥␦ in Peyer's patches (546% of sham control values) and a concomitant decrease in TCR␣ (55% of sham control values).…”
“…Gryglewski et al postulated that operations such as gastrectomy might increase the number of T cells in Peyer's patches and mesenteric lymph nodes by stimulating the passage of these cells from peripheral blood into the lymphatic organs. 23 The circular and longitudinal muscle layers showed signs of hypertrophy. Therefore, it is possible that muscle cell hypertrophy in the muscular layer is caused by uncontrolled and fast food passage into the digestive tract, and irregular intestinal movement in the absence of the pyloric sphincter after total gastrectomy.…”
These data indicate that the contractile response to various agents is altered after total gastrectomy and that receptor-mediated mechanisms may cause these changes.
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