Different structural types of hetero-metal bis(citrato)germanates with 1,10-phenanthroline: Targeted synthesis, spectral, thermal properties and Hirshfeld surface analysis

Марцинко, Е. Э.; Buchko, O. V.; Chebanenko, E. А.; Сейфулліна, І. Й.; Dyakonenko, Viktoriya V.; Shishkina, Svitlana V.

doi:10.1016/j.molstruc.2021.130297

Cited by 4 publications

(2 citation statements)

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“…To modify the enzymatic activity, purposefully synthesized multi-ligand germanium-3dmetal complexes with citric acid, phenanthroline, and bipyridine were used for the fi rst time: 6), where phen is 1,10-phenanthroline, bipy is 2,2'-bipyridine, and H 4 Cit is citric acid. 6)) [9][10][11]. Schemes of compound structures are shown in Fig.…”

Section: ][Ge(hcit) 2 ]•3h 2 O (1); [Ni(phen) 3 ][Ge(hcit) 2 ]•2h 2 O...mentioning

confidence: 99%

Influence of New Types of Biscitratogermanates on Penicillium restrictum α-L-Rhamnosidase

et al. 2023

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The intensive development of biotechnology in the last decade is largely determined by the growing requirement needs of both medicine and various industries for products of microbial synthesis, including glycosidases, in particular α-L-rhamnosidases. Their wide use to solve current biological-medical and chemical-technological problems stimulates researchers to search for compounds capable of influencing their catalytic activity. Therefore, the purpose of this work was to isolate and purify α-L-rhamnosidase from a new producer of Penicillium restrictum and to investigate multi-ligand germanium-3d-metal complexes with citric acid, phenanthroline, and bipyridine as effectors of its activity. Methods. The object of the study was α-L-rhamnosidase of P. restrictum. Its purification was carried out by gel filtration and ion exchange chromatography on TSK-gels and Sepharose 6B. The activity of α-L-rhamnosidase was determined using the Davis method with naringin as a substrate. As modifiers of enzyme activity, purposefully synthesized multiligand germanium-3d-metal complexes with citric acid, phenanthroline, and bipyridine ([Ni(bipy)3][Ge(HCit)2]·3H2O (1); [Ni(phen)3][Ge(HCit)2]·2H2O (2); [{Cu(bipy)2}2Ge(m-Cit)2]·12Н2О (3); [{Cu(phen)2}2Ge(m-Cit)2]·13H2O (4); [Zn(bipy)3][Ge(HCit)2]·2H2O (5); [Zn(phen)3][Ge(HCit)2]·3H2O (6)), were used. Results. From the supernatant of culture fluid of P. restrictum, α-L-rhamnosidase was isolated and purified 23.1 times with a yield of 0.09%. The specific activity of the enzyme was 27.8 units/mL. The enzyme was homogeneous according to gel filtration on Sepharose 6B and had a molecular mass of 50 kDa. It was established that the considered coordination compounds are able to regulate the catalytic activity of α-L-rhamnosidase of P. restrictum. All of them manifest themselves either as activators or as inert substances, no inhibition was observed. In addition, the dependence of the degree of enzyme activation by the compounds on their concentration is traced and corresponds to the following series: at a concentration of 0.01% — 1 > 6 ≈ 5 > 3 >2 ≈ 4 and at a concentration of 0.1% — 1 > 4 > 2 > 5 ≈ 6. 3. The catalytic activity is also significantly affected by the time of exposure to the compounds: at a concentration of 0.01% for 1h, the activity of the enzyme at the control level was observed for all compounds, whereas at a concentration of 0.1% for 24 h, the activity increased sharply in the presence of compounds 1 (300%), 6 (153%), and 2 (134%). The action of the others was at the control level. Conclusions. The obtained data on new complex metal compounds with an activating effect on microbial α-L-rhamnosidases. It has been established that compounds whose structural organization ensures the synergism of the action of all components are the most promising enzyme effectors in a series of coordination compounds of biologically active metals and ligands.

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Section: ][Ge(hcit) 2 ]•3h 2 O (1); [Ni(phen) 3 ][Ge(hcit) 2 ]•2h 2 O...mentioning

confidence: 99%

Influence of New Types of Biscitratogermanates on Penicillium restrictum α-L-Rhamnosidase

et al. 2023

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“…В ході систематичного дослідження на кафедрі прикладної хімії та хімічної освіти ОНУ імені І. І. Мечникова було синтезовано ряд різнометальнозмішанолігандних комплексів германію(IV) та 3d-металів з лимонною кислотою та 1,10-фенантроліном [8][9][10][11][12][13], для комплексів купруму та цинку було встановлено особливості міжмолекулярних взаємодій методом поверхонь Хіршфельда [12,13].…”

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HIRSHFELD SURFACE ANALYSIS OF CRYSTALS OF COMPLEXES - PRODUCTS OF REACTION IN SYSTEMS МХ2 – 1,10-PHENANTHROLINE – GeO2 – CITRIC ACID (М = Ni, Co; X = Cl, CH3COO)

Buchko

2021

Вісник ОНУ

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Intermolecular interactions in the coordination compounds of cation-anionic type [Ni(phen)3][Ge(HCit)2]·2H2O (I), [Co(phen)3][Ge(HCit)2]⋅2H2O (II), [Co(H2O)2(phen)2]2[Ge(Cit)2]·4H2O (III) were characterized using Hirshfeld surface analysis. It was established that the biggest contribution in the Hirshfeld surface of anions have been made by the bonds H … В / О …Н (57,8 % (I), 59,6 % (II), 63,9 % (III)), H … H (28,2 % (I), 24,9 % (II), 31,4 % (III)). At the same time interactions C … H / Н … С are less significant (9,6 %, 11,2 % and 3,2 % for I, II, III, respectively). The calculated percentage contribution of different intermolecular interactions of cations in the crystals showed, that, unlike the anions, contacts H … Н (37,9 % (IА), 38,6 % (IB), 36,2 % (IIА и IIB), 38,8 % (III)) play dominating role, while contribution of H … В / О … Н is less (26,5 % (IA and IB), 28,3 % (IIA), 24,5 % (IIB), 26 2 % (III)). Furthermore, interactions C … H / Н … С are more significant than in anions (24,8 % (IА), 27,2 % (IB), 25,6 % (IIА), 26,2 % (IIB), 21,3 % (III). It is typical for cations to have С …С bonds (5,5 % in average) that give contribution less then 1 %. It was determined that voids volume in the crystals of compounds I–III is 751,74 (I), 778,21 (II) and 423,23 (III) Å3 and surface area is 1772,28 (I), 1821,36 (II) and 628,38 (III) Å2. The total volume of the voids (15 % in I, 15,7 %, in II, 22,4 % in III) testifies the lack of big cavities in the frames of the studied compounds. Thereby analysis of intermolecular interactions with the help of Hirshfeld surface analysis showed the dominating role of hydrogen bonds H … O / O …H and contacts H … H, and minor contribution of C … H / H … C and С … С bonds for all studied compounds. The absence of p-p stacking interactions between aromatic rings of 1,10-phenanthroline in the cations of complexes I–III was also pointed out.

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Spectrophotometric and DFT study of Germanium(IV) interaction with 6,7-dihydroxy-2,4-diphenyl-1-benzopyran-1-ium bromide in solutions: Room-temperature cloud point extraction and its analytical application

Zhukovetska,

Fizer,

Mariychuk

et al. 2024

Journal of Molecular Liquids

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Different structural types of hetero-metal bis(citrato)germanates with 1,10-phenanthroline: Targeted synthesis, spectral, thermal properties and Hirshfeld surface analysis

Cited by 4 publications

References 20 publications

Influence of New Types of Biscitratogermanates on Penicillium restrictum α-L-Rhamnosidase

Influence of New Types of Biscitratogermanates on Penicillium restrictum α-L-Rhamnosidase

HIRSHFELD SURFACE ANALYSIS OF CRYSTALS OF COMPLEXES - PRODUCTS OF REACTION IN SYSTEMS МХ2 – 1,10-PHENANTHROLINE – GeO2 – CITRIC ACID (М = Ni, Co; X = Cl, CH3COO)

Spectrophotometric and DFT study of Germanium(IV) interaction with 6,7-dihydroxy-2,4-diphenyl-1-benzopyran-1-ium bromide in solutions: Room-temperature cloud point extraction and its analytical application

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