Different systems in the posterior hypothalamic nucleus of rats control theta frequency and trigger movement

Woodnorth, Mary-Anne; McNaughton, Neil

doi:10.1016/j.bbr.2005.04.004

Cited by 15 publications

(13 citation statements)

References 41 publications

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“…Several studies have since replicated this finding in both rats and other species, including mice, guinea pigs, rabbits, cats, and dogs (Arnolds et al, 1979, Shen et al, 1997, Czurko et al, 1999, Ekstrom et al, 2001, Geisler et al, 2007, Chen et al, 2011, Li et al, 2012, Chen et al, 2013). A similar and related finding is that oscillatory frequency also increases with running speed; this frequency shift is fairly slight (<1Hz in some cases) (Geisler et al, 2007) although consistently observed in several reports (Recce, 1994, Oddie et al, 1996, Shen et al, 1997, Woodnorth and McNaughton, 2005, Geisler et al, 2007, Chen et al, 2011, Li et al, 2012). The increases in theta power and frequency with running speed are often considered benchmark findings on low-frequency oscillations and have had a significant influence on theories detailing the functional significance of theta during both navigation and memory (Bland and Oddie, 2001, Hasselmo et al, 2002, Buzsaki, 2006).…”

Section: Rodent Hippocampal Low-frequency Oscillations and Correlatiosupporting

confidence: 80%

Multifaceted roles for low-frequency oscillations in bottom-up and top-down processing during navigation and memory

Ekstrom

Watrous

2014

NeuroImage

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A prominent and replicated finding is the correlation between running speed and increases in low-frequency oscillatory activity in the hippocampal local field potential. A more recent finding concerns low-frequency oscillations that increase in coherence between the hippocampus and neocortical brain areas such as prefrontal cortex during memory-related behaviors (i.e., remembering the correct arm to explore). In this review, we tie together movement-related and memory-related low-frequency oscillations in the rodent with similar findings in humans. We argue that although movement-related low-frequency oscillations, in particular, may have slightly different characteristics in humans than rodents, placing important constraints on our thinking about this issue, both phenomena have similar functional foundations. We review four prominent theoretical models that provide partially conflicting accounts of movement-related low-frequency oscillations. We attempt to tie together these theoretical proposals, and existing data in rodents and humans, with memory-related low-frequency oscillations. We propose that movement-related low-frequency oscillations and memory-related low-frequency oscillatory activity, both of which show significant coherence with oscillations in other brain regions, represent different facets of “spectral fingerprints,” or different resonant frequencies within the same brain networks underlying different cognitive processes. Together, movement-related and memory-related low-frequency oscillatory coupling may be linked by their distinct contributions to bottom-up, sensorimotor driven processing and top-down, controlled processing characterizing aspects of memory encoding and retrieval.

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Section: Rodent Hippocampal Low-frequency Oscillations and Correlatiosupporting

confidence: 80%

Multifaceted roles for low-frequency oscillations in bottom-up and top-down processing during navigation and memory

Ekstrom

Watrous

2014

NeuroImage

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“…In agreement with the above data it is accepted that the SuM is involved in HPC theta frequency programming in rats during immobility (Vertes, 1992;Kirk and McNaughton, 1991;Bland et al, 1995;Kirk, 1998;Woodnorth et al, 2003;Woodnorth and McNaughton, 2005). To further underline the importance of this process, many authors have suggested that a specific frequency of theta oscillations is essential to maintain proper function of the hippocampus (Kirk, 1998;Kirk and Mackay, 2003;Woodnorth et al, 2003;Woodnorth and McNaughton, 2005). Thinschmidt et al (1995) demonstrated that SuM lesions in freely moving animals did not affect spontaneous HPC theta occurrence indicating the MS/ vDBB takes the lead role in pacing hippocampal theta rhythm frequency in these conditions.…”

Section: Introductionsupporting

confidence: 81%

“…The significance of the SuM and PH nuclei in the process of transducing and modulating the frequency of hippocampal theta rhythm is a well‐known fact. Most of the published data so far has suggested the role of PHa neuronal activity in HPC theta frequency programming (Vertes, ; Kirk and McNaughton, ; Bland et al, ; Kirk, ; Woodnorth et al, ; Woodnorth and McNaughton, ). Regardless however of a number of existing reports on PHa local theta rhythm observed in vivo (Bland and Vanderwolf, ; Grass et al, ; Sławinska and Kasicki, ; Kocsis and Vertes, ; Kowalczyk et al, ; Bocian et al, ; ) and in vitro (Kowalczyk et al, ; Bocian et al, ) the relevance of these oscillations is yet to be fully understood.…”

Section: Discussionmentioning

confidence: 99%

Postnatal Development of the Posterior Hypothalamic Theta Rhythm and Local Cell Discharges in Rat Brain Slices

Caban

Staszelis

Kazmierska

et al. 2018

Developmental Neurobiology

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Theta rhythms have been recorded from rat brain slices of the posterior hypothalamic area (PHa), including the supramammillary and posterior hypothalamic nuclei. Additionally, in numerous studies theta-related neurons were identified in the PHa according to the classification of Bland and Colom (Progress in Neurobiology, 41, 157-208, 1993). It is currently widely accepted that the PHa contributes to the process of HPC theta frequency programming at least in certain behavioral states. The postnatal development of the HPC and its ability to generate theta has also been a subject of studies. Specifically, it was found that theta oscillations are present in the HPC of 8-10 days old rat pups and turn into a well-synchronized and high-amplitude activity in the following few days. In our current study, we therefore focused on the postnatal development of cholinergically-induced theta rhythm and theta-related neuronal activity in PHa slices obtained from 8 to 24 days old rat pups. Theta activity was observed in the PHa preparations at the age of 8-10 days and then progressively increased its probability of occurrence, amplitude and synchrony up to the age of 22-24 days when it reached a plateau phase. A steady increase in the number of recorded neurons correlated with local theta oscillations was also observed.

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“…Notably, very high densities of RLN3/RXFP3 were observed within the hippocampus and regions that regulate its function, including the medial septum/nucleus of the diagonal band, posterior hypothalamus, and supramammillary, interpeduncular, and median raphé nuclei, which together constitute the septohippocampal pathway (see e.g., Vertes, 1981;Vertes and Kocsis, 1997;Kirk, 1998;Pedemonte et al, 1998;Woodnorth et al, 2003;Woodnorth and McNaughton, 2005;Jackson et al, 2008). High levels of RLN3/RXFP3 were also observed in arousal-related brain areas, such as the raphé nuclei, lateral hypothalamus, and periaqueductal gray, while lower levels were present in other arousal structures, such as the ventral tegmental area and the pedunculopontine tegmental nucleus (see e.g., Mieda and Yanagisawa, 2002;Saper et al, 2005;Lu et al, 2006;Monti and Jantos, 2008).…”

Section: Discussionmentioning

confidence: 96%

Distribution of relaxin‐3 and RXFP3 within arousal, stress, affective, and cognitive circuits of mouse brain

Smith

Shen

Banerjee

et al. 2010

J of Comparative Neurology

137

264

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Relaxin-3 (RLN3) and its native receptor, relaxin family peptide 3 receptor (RXFP3), constitute a newly identified neuropeptide system enriched in mammalian brain. The distribution of RLN3/RXFP3 networks in rat brain and recent experimental studies suggest a role for this system in modulation of arousal, stress, metabolism, and cognition. In order to facilitate exploration of the biology of RLN3/RXFP3 in complementary murine models, this study mapped the neuroanatomical distribution of the RLN3/RXFP3 system in mouse brain. Adult, male wildtype and RLN3 knock-out (KO)/LacZ knock-in (KI) mice were used to map the central distribution of RLN3 gene expression and RLN3-like immunoreactivity (-LI). The distribution of RXFP3 mRNA and protein was determined using [(35)S]-oligonucleotide probes and a radiolabeled RXFP3-selective agonist ([(125)I]-R3/I5), respectively. High densities of neurons expressing RLN3 mRNA, RLN3-associated beta-galactosidase activity and RLN3-LI were detected in the nucleus incertus (or nucleus O), while smaller populations of positive neurons were observed in the pontine raphé, the periaqueductal gray and a region adjacent to the lateral substantia nigra. RLN3-LI was observed in nerve fibers/terminals in nucleus incertus and broadly throughout the pons, midbrain, hypothalamus, thalamus, septum, hippocampus, and neocortex, but was absent in RLN3 KO/LacZ KI mice. This RLN3 neural network overlapped the regional distribution of RXFP3 mRNA and [(125)I]-R3/I5 binding sites in wildtype and RLN3 KO/LacZ KI mice. These findings provide further evidence for the conserved nature of RLN3/RXFP3 systems in mammalian brain and the ability of RLN3/RXFP3 signaling to modulate "behavioral state" and an array of circuits involved in arousal, stress responses, affective state, and cognition.

show abstract

Different systems in the posterior hypothalamic nucleus of rats control theta frequency and trigger movement

Cited by 15 publications

References 41 publications

Multifaceted roles for low-frequency oscillations in bottom-up and top-down processing during navigation and memory

Multifaceted roles for low-frequency oscillations in bottom-up and top-down processing during navigation and memory

Postnatal Development of the Posterior Hypothalamic Theta Rhythm and Local Cell Discharges in Rat Brain Slices

Distribution of relaxin‐3 and RXFP3 within arousal, stress, affective, and cognitive circuits of mouse brain

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