Different VDR, VDBP genotypes and vitamin D levels may effect obstructive sleep apnea syndrome

Kıraç, Deniz; Yassa, Özge Yağcıoğlu; Gezmis, Hazal; Domac, Saime Fusun Mayda; Altunok, Elif Çiğdem; Genç, Ece

doi:10.14715/cmb/2019.65.1.8

Cited by 11 publications

(6 citation statements)

References 32 publications

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“…Only two small studies have investigated the role of VDR polymorphisms in other sleep disorders. In the first study, Kirac et al 53 investigated two VDR gene polymorphisms (FokI and BsmI) in 50 individuals with obstructive sleep apnea (OSA) and 50 healthy individuals. They showed that VDR polymorphisms were significantly associated with OSA 53 .…”

Section: Discussionmentioning

confidence: 99%

“…In the first study, Kirac et al 53 investigated two VDR gene polymorphisms (FokI and BsmI) in 50 individuals with obstructive sleep apnea (OSA) and 50 healthy individuals. They showed that VDR polymorphisms were significantly associated with OSA 53 . A second study conducted by Abbas et al (2019) recruited 240 Egyptian adults with OSA and 120 matched controls and found a gradient dose–response, as one mutated allele (Ff) increased the risk of OSA by more than two times (OR: 2.66, p = 0.03), and when both mutated alleles were present (ff) the risk of OSA was 10 times higher (OR: 10.59, p < 0.001) 12 .…”

Section: Discussionmentioning

confidence: 99%

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The role of interaction between vitamin D and VDR FokI gene polymorphism (rs2228570) in sleep quality of adults

Menezes-Júnior,

Sabião,

Moura

et al. 2024

Sci Rep

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To evaluate association of vitamin D with sleep quality in adults and the influence of VDR-gene polymorphism FokI (rs2228570;A > G). Cross-sectional population-based study in adults, conducted in Brazil. The outcome was sleep-quality, evaluated by the Pittsburgh Sleep Quality Index. Vitamin D was determined by indirect electrochemiluminescence and classified as deficiency (VDD), 25(OH)D < 20 ng/mL in a healthy population or 25(OH)D < 30 ng/mL for groups at risk for VDD. FokI polymorphism in the VDR-gene was genotyped by qPCR and classified as homozygous wild (FF or AA), heterozygous (Ff or AG), or homozygous mutant (ff or GG). Multivariate logistic analysis was used to estimate the association between vitamin D and FokI polymorphism with sleep-quality. In a total of 1674 individuals evaluated, 53.6% had poor-sleep-quality, 31.5% had VDD, and the genotype frequency of the FokI polymorphism was 9.9% FF, 44.6% Ff, and 45.5% ff. In multivariate analysis, individuals with VDD had 1.51 times the chance of poor-sleep-quality, and individuals with the ff genotype had 1.49 times the chance of poor-sleep-quality (OR:1.49;95%CI:1.05–2.12) when compared to individuals with the FF or Ff genotype. In the combined analysis, individuals with VDD and ff genotype had more chance of poor-sleep-quality than individuals with sufficient vitamin D and genotype Ff or FF (OR:2.19;95%CI:1.27–3.76). Our data suggest that VDD and VDR FokI gene polymorphism are associated with poor-sleep-quality, and combining the two factors increases the chance of poor-sleep-quality compared to separate groups.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The role of interaction between vitamin D and VDR FokI gene polymorphism (rs2228570) in sleep quality of adults

Menezes-Júnior,

Sabião,

Moura

et al. 2024

Sci Rep

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“…Vitamin D pathway genes, such as VDR, CYP27A1, CYP27B1, CYP2R1, CYP24A1 , and vitamin D binding protein ( VDBP ) not only control vitamin D biosynthesis and its transport but also influence the cytokine levels in various autoimmune diseases, including T1D ( 54 , 55 , 56 ). Vitamin D plays a major role in the regulation of insulin secretion from pancreatic β-cells ( 57 , 58 ). VDR polymorphisms in the 3´UTR region are well known to affect its translation and mRNA stability.…”

Section: Discussionmentioning

confidence: 99%

Association of Vitamin D Deficiency and Vitamin D Receptor Gene Polymorphisms with Type 1 Diabetes Risk: A South Indian Familial Study

Thirunavukkarasu,

Chitra,

Asirvatham

et al. 2024

Jcrpe

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Objective: Vitamin D is a potent immune modulator and is associated with autoimmune diseases, including type 1 diabetes (T1D). The vitamin D levels and its receptor gene polymorphisms together in T1D are not yet investigated in the South Indian population. The present study focused on exploring the significance of vitamin D levels and vitamin D receptor (VDR) gene polymorphisms with the risk of developing T1D in the South Indian population. Methods: Patients with T1D and unaffected first-degree relatives (FDRs) were included in this study. Genotyping of VDR polymorphisms at four different loci (FokI- F/f, BsmI- B/b, TaqI- T/t, and ApaI- A/a) was assessed through the amplification refractive mutation system-polymerase chain reaction method. Serum vitamin D levels were measured in 98 T1D patients and 75 age- and sex-matched siblings. Results: A total of 120 patients with T1D and 214 FDRs were included. Vitamin D deficiency (VDD) was observed in a higher proportion of T1D patients than in controls (52% vs. 32%; p<0.03). The frequency of the FokI-FF genotype was significantly higher [odds ratio (OR)=1.66; p<0.03] in T1D patients conferring a susceptible association with the disease. Nevertheless, the increased frequency of heterozygous Ff genotype (OR=0.57; p<0.02) among controls may confer a protective association with T1D. Furthermore, the transmission disequilibrium test revealed over-transmission of ApaI-A (T: U=15/5; p<0.006) and BsmI-B alleles (T: U=17/5; p<0.01) and under-transmission of BsmI-b/ApaI-a/TaqI-T haplotype (T: U=5.4/14.4; p=0.04) from parents to T1D patients. Conclusion: The present study concludes that VDD is the major contributing risk factor to T1D development in the South Indian population. Furthermore, the FokI-FF genotype, BsmI-B, and ApaI-A alleles were positively associated with T1D. In contrast, the FokI-Ff genotype and BsmI-b/ApaI-a/TaqI-T haplotype were negatively associated with T1D.

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“…It has also been shown that the VDR FokI polymorphism is associated with excessive daytime sleepiness. Kirac et al [ 33 ] investigated VDR FokI (rs2228570) and B sm I (rs1544410) and vitamin D-binding protein rs4588 and rs7041 mutations in OSAS patients. They reported that CA genotype in rs4588, CC genotype in rs2228570, and AA genotype in rs1544410 mutations were statistically significant in patients.…”

Section: Discussionmentioning

confidence: 99%

Relationship between vitamin D in obstructive sleep apnea syndrome and psoriasis patients

Albayrak¹,

Fazlıoǧlu²,

Batar³

et al. 2022

pdia

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Introduction Although psoriasis and obstructive sleep apnea syndrome (OSAS) are associated with systemic inflammation, studies on their potential bilateral relationship are not sufficient. Aim To investigate vitamin D levels and receptor gene polymorphisms in patients with OSAS and psoriasis and the associations with these diseases. Material and methods One hundred thirty-seven patients included in the study consisted of 4 different groups: group 1, those with both diseases; group 2, those with OSAS only; group 3, patients with psoriasis only; and group 4, healthy controls. The patients’ serum calcium, phosphorus, AHI, Epworth Sleepiness Scale, Psoriasis Area Severity Index, and VDR TagI, A pa I, Bs m I polymorphisms were compared. Results Vitamin D levels of groups 1, 2 and 3 were found to be lower than in controls. There was no statistically significant correlation between VDR TagI, A pa I, B sm I gene polymorphisms of the groups. Vitamin D levels were significantly higher in patients with heterozygous A pa I genotype (A/C) compared to patients with normal (A/A) or homozygous mutant (C/C) genotype ( p < 0.05). No relationship was determined between VDR TagI, A pa I, B sm I, and the other parameters. Conclusions In our study, 1,25(OH) 2 -vitamin D 3 levels were significantly lower in all disease groups compared to the control group. Although there is no difference between the groups in terms of VDR gene polymorphism, we think that there may be a bidirectional relationship between these diseases based on the low vitamin D levels.

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Different VDR, VDBP genotypes and vitamin D levels may effect obstructive sleep apnea syndrome

Cited by 11 publications

References 32 publications

The role of interaction between vitamin D and VDR FokI gene polymorphism (rs2228570) in sleep quality of adults

The role of interaction between vitamin D and VDR FokI gene polymorphism (rs2228570) in sleep quality of adults

Association of Vitamin D Deficiency and Vitamin D Receptor Gene Polymorphisms with Type 1 Diabetes Risk: A South Indian Familial Study

Relationship between vitamin D in obstructive sleep apnea syndrome and psoriasis patients

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