2014
DOI: 10.1093/cercor/bhu278
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Differential Alterations of Auditory Gamma Oscillatory Responses Between Pre-Onset High-Risk Individuals and First-Episode Schizophrenia

Abstract: Alterations in gamma-band auditory steady-state response (ASSR) are the most robust finding of abnormal neural oscillations in patients with first-episode (FES) and chronic schizophrenia. Gamma-band ASSRs may indicate GABAergic interneuron dysfunction. Nevertheless, it is unknown whether abnormal gamma-band ASSRs are present before the onset of psychosis. Subjects were 15 ultra-high-risk (UHR) individuals, 13 FES patients, and 21 healthy control (HC) subjects. We performed electroencephalogram recordings and m… Show more

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Cited by 141 publications
(172 citation statements)
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“…211,212 However, evidence that gamma band abnormalities are present prior to the onset of psychosis, is far from robust, 213 and if present, may be restricted to the later portion of the auditory steady-state response. 214 As such, this pattern of findings may cast doubt on its role as a trait-like vulnerability marker. On the other hand, as discussed below, unaffected relatives of patients with schizophrenia also show gamma effects, which is consistent with an inherited, trait-like deficit.…”
Section: Gammamentioning
confidence: 99%
“…211,212 However, evidence that gamma band abnormalities are present prior to the onset of psychosis, is far from robust, 213 and if present, may be restricted to the later portion of the auditory steady-state response. 214 As such, this pattern of findings may cast doubt on its role as a trait-like vulnerability marker. On the other hand, as discussed below, unaffected relatives of patients with schizophrenia also show gamma effects, which is consistent with an inherited, trait-like deficit.…”
Section: Gammamentioning
confidence: 99%
“…In addition, there is a growing interest in employing MEG to understand neural oscillations in brain disorders with the potential to yield biomarkers for early detection and diagnosis (e.g. Georgopoulos et al, 2010;Rojas et al, 2011;Sun et al, 2013;Tada et al, 2014).…”
Section: Accepted Manuscriptmentioning
confidence: 99%
“…In addition, ASSRs have been investigated in psychiatric disorders and reduced amplitude as well as phase-consistency of evoked ASSR to 40Hz stimulation have been observed in ScZ (e.g. Brenner et al, 2003;Hamm et al, 2011;Hirano et al, 2015;Krishnan et al, 2009;Kwon et al, 1999; A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT TAN-GROSS-UHLHAAS_MEG-ASSR-RETEST 7 | P a g e Light et al, 2006;Spencer et al, 2008;Tada et al, 2014; however see Hamm et al, 2012) and their first-degree relatives (Hong et al, 2004;Rass et al, 2012) as well as in ASDs (Wilson et al, 2007).…”
Section: Accepted Manuscriptmentioning
confidence: 99%
“…The authors suggested that diminished neural synchronization to stimuli, regardless of their task relevance, is occurring in an environment of generally excessive synchrony. Tada et al (2014) investigated the time-course of the auditory gamma-band response in a FEP and in a UHR group and they showed a reduction of early-latency (0-100 ms) gamma-band in the FES group and a reduction of late-latency (300-500 ms) gamma-band in both UHR and FEP groups. Therefore, the early gamma-band response may be reduced after the onset of psychosis in accordance with the staging model, whereas the late gamma-band response may be impaired before the onset of psychosis and considered an endophenotype.…”
Section: Gamma Phase Synchronymentioning
confidence: 99%