Differential Amplitude of Low-Frequency Fluctuations in brain networks after BCI Training with and without tDCS in Stroke

Hu, Mengjiao; Ji, Fang; Lu, Zhongkang; Huang, Weimin; Khosrowabadi, Reza; Zhao, Ling; Ang, Kai Keng; Phua, Kok Soon; Nasrallah, Fatima A.; Chuang, Kai‐Hsiang; Stephenson, Mary C.; Totman, John J.; Jiang, Xudong; Chew, Effie; Guan, Cuntai; Zhou, Juan

doi:10.1109/embc.2018.8512395

Cited by 5 publications

(5 citation statements)

References 26 publications

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“…In addition, the previous studies showed that there were significantly increased ALFF in motor cortical areas (i.e., supplementary motor area) and cognitive cortical areas (i.e., hippocampus, parahippocampus), and significantly decreased ALFF in the cerebellum in stroke patients ( Tsai et al, 2014b ; Xie et al, 2022 ). Altered ALFF can also be detected in chronic stroke patients before and after treatment intervention ( Hu et al, 2018 ). The sReHo indicates the similarity of local neural activity among adjacent regions, which is measured by Kendall coefficients.…”

Section: Introductionmentioning

confidence: 99%

Altered static and dynamic spontaneous neural activity in patients with ischemic pontine stroke

Wang

Liu

et al. 2023

Front. Neurosci.

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ObjectiveThe purpose of the study was to investigate the abnormality both of static spontaneous brain activity and dynamic temporal variances following a pontine infarction.MethodsForty-six patients with chronic left pontine infarction (LPI), thirty-two patients with chronic right pontine infarction (RPI), and fifty healthy controls (HCs) were recruited for the study. The static amplitude of low-frequency fluctuations (sALFF), static regional homogeneity (sReHo), dynamic ALFF (dALFF), and dynamic ReHo (dReHo) were employed to detect the alterations in brain activity induced by an infarction. The Rey Auditory Verbal Learning Test and Flanker task were used to evaluate the verbal memory and visual attention function, respectively. Receiver operating characteristic curve analysis was used to reveal the potential capacity of these metrics to distinguish the patients from HCs.ResultsThere were significant variations of these static and dynamic metrics in patients with chronic pontine infarction. The altered regions involved the supratentorial regions, including cortex and subcortical. Moreover, the altered metrics were significantly correlated with verbal memory and visual attention. In addition, these static and dynamic metrics also showed potential in distinguishing stroke patients with behavior deficits from HCs.ConclusionThe pontine infarction-induced cerebral activation changes are observed in both motor and cognitive systems, indicating the functional damage and reorganization across the global cerebral level in these patients with subtentorial infarction, and there is a reciprocal effect between motor and cognitive impairment and repair.

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Section: Introductionmentioning

confidence: 99%

Altered static and dynamic spontaneous neural activity in patients with ischemic pontine stroke

Wang

Liu

et al. 2023

Front. Neurosci.

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“…Transcranial direct current stimulation (tDCS) Only three neurodegenerative diseases were considered by using tDCS. Twelve articles considered stroke-related diseases: those by Ang et al ( 2012 , 2015 ), Kasashima-Shindo et al ( 2015 ), Handiru et al ( 2017 ), Hong et al ( 2017 ), Hu et al ( 2018 , 2021 ), Rodríguez-Ugarte et al ( 2018a ), Mane et al ( 2019 ), Chew et al ( 2020 ), Quiles et al ( 2020 ), and Bigoni et al ( 2022 ). Ten articles used tDCS to study the motor cortex: those by Wei et al ( 2013 ), Dutta et al ( 2014 ), He et al ( 2014 ), Soekadar et al ( 2014 , 2015 ), Takeuchi et al ( 2015 ), Naros et al ( 2016 ), Rodriguez-Ugarte et al ( 2018 ), Rodríguez-Ugarte et al ( 2018b ), and Ortiz et al ( 2020 ).…”

Section: Resultsmentioning

confidence: 99%

On closed-loop brain stimulation systems for improving the quality of life of patients with neurological disorders

Belkacem

Jamil

Khalid

et al. 2023

Front. Hum. Neurosci.

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Emerging brain technologies have significantly transformed human life in recent decades. For instance, the closed-loop brain-computer interface (BCI) is an advanced software-hardware system that interprets electrical signals from neurons, allowing communication with and control of the environment. The system then transmits these signals as controlled commands and provides feedback to the brain to execute specific tasks. This paper analyzes and presents the latest research on closed-loop BCI that utilizes electric/magnetic stimulation, optogenetic, and sonogenetic techniques. These techniques have demonstrated great potential in improving the quality of life for patients suffering from neurodegenerative or psychiatric diseases. We provide a comprehensive and systematic review of research on the modalities of closed-loop BCI in recent decades. To achieve this, the authors used a set of defined criteria to shortlist studies from well-known research databases into categories of brain stimulation techniques. These categories include deep brain stimulation, transcranial magnetic stimulation, transcranial direct-current stimulation, transcranial alternating-current stimulation, and optogenetics. These techniques have been useful in treating a wide range of disorders, such as Alzheimer's and Parkinson's disease, dementia, and depression. In total, 76 studies were shortlisted and analyzed to illustrate how closed-loop BCI can considerably improve, enhance, and restore specific brain functions. The analysis revealed that literature in the area has not adequately covered closed-loop BCI in the context of cognitive neural prosthetics and implanted neural devices. However, the authors demonstrate that the applications of closed-loop BCI are highly beneficial, and the technology is continually evolving to improve the lives of individuals with various ailments, including those with sensory-motor issues or cognitive deficiencies. By utilizing emerging techniques of stimulation, closed-loop BCI can safely improve patients' cognitive and affective skills, resulting in better healthcare outcomes.

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“…ALFF can reflect the intensity of the nerve activity of a single voxel and hemodynamic BOLD information on neural activity [ 45 ]. In addition to FC, regional ALFF may provide complementary information on the neural mechanism [ 46 ]. After brain injury, the blood flow of the brain decreases, and the local ALFF value shows a downward trend.…”

Section: Methodsmentioning

confidence: 99%

Neuromodulatory Effect of Sensorimotor Network Functional Connectivity of Temporal Three-Needle Therapy for Ischemic Stroke Patients with Motor Dysfunction: Study Protocol for a Randomized, Patient-Assessor Blind, Controlled, Neuroimaging Trial

Zhao

Zhang

Liu

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. The clinical efficacy of temporal three-needle therapy for stroke dysfunction has been previously demonstrated in China. However, the central mechanism of temporal three-needle therapy remains unclear. Temporal three-needle projects the sensory cortex and the motor cortex, which may impact the cortex function. Current studies seldom focus on it. Hence, according to the “scalp-cortex corresponding theory,” the underlying mechanism of temporal three-needle remains a domain for further research. Methods. This trial is designed to provide objective and visual evidence for the neuromodulatory effect and neuroimaging mechanism of temporal three-needle therapy for stroke patients. This ongoing study is a prospective, randomized, controlled, patient-assessor blind, single-center, neuroimaging trial involving two-parallel patient groups and a healthy control group. Forty eligible patients will be recruited from Shenzhen Nanshan District People’s Hospital and randomized into either the experimental group or the control group. Twenty healthy volunteers will be recruited in the healthy control group and undergo baseline magnetic resonance imaging scans without any intervention. Patients in the control group will receive acupuncture at Dingnieqianxiexian (MS6), in addition to basic medicine and rehabilitative treatments. Patients in the experimental group will receive temporal three-needle therapy plus basic medicine and rehabilitative treatments 5 days per week, 10 sessions over two consecutive weeks. The primary outcome is resting-state functional connectivity, and the secondary outcomes are regional homogeneity, amplitude of low-frequency fluctuations, Fugl–Meyer assessment of the upper limb, and modified Barthel Index. All outcome measures will be assessed at baseline and after 2 weeks of intervention. Discussion. The results will explore the neuromodulatory effects and illustrate the central mechanism of temporal three-needle treatment from the network-level viewpoint of sensorimotor network functional plasticity and promote widespread application in real-world practice. This trial was registered at Chinese Clinical Trial Registry on 14 March 2018 with ChiCTR1800015209.

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Differential Amplitude of Low-Frequency Fluctuations in brain networks after BCI Training with and without tDCS in Stroke

Cited by 5 publications

References 26 publications

Altered static and dynamic spontaneous neural activity in patients with ischemic pontine stroke

Altered static and dynamic spontaneous neural activity in patients with ischemic pontine stroke

On closed-loop brain stimulation systems for improving the quality of life of patients with neurological disorders

Neuromodulatory Effect of Sensorimotor Network Functional Connectivity of Temporal Three-Needle Therapy for Ischemic Stroke Patients with Motor Dysfunction: Study Protocol for a Randomized, Patient-Assessor Blind, Controlled, Neuroimaging Trial

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