Differential and correlational tractography as tract‐based biomarkers in mild traumatic brain injury: A longitudinal MRI study

Huang, Shuqiang; Li, Mengjun; Yeh, Fang‐Cheng; Huang, Chuxin; Zhang, Huiting; Liu, Jun

doi:10.1002/nbm.4991

Cited by 4 publications

(1 citation statement)

References 90 publications

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“…Other similar approaches use linear mixed effects models where each streamline is considered as a within-subject random factor 67 or use correction approaches analogous to those used in fMRI. 265 One of the benefits of tractometry is that it transforms the hard-to-understand measurements of volumetric MRI data to a tabular “tidy” format, 266 while substantially reducing its dimensionality and retaining important information about the biological properties of the measurements. This format is relatively easy to share with and communicate to researchers in data analysis fields, such as statistics and machine learning, and can provide a basis for reproducible and robust inter-disciplinary research.…”

Section: Future Perspectives and Open Questionsmentioning

confidence: 99%

Tractometry of Human Visual White Matter Pathways in Health and Disease

Takemura,

Kruper,

Miyata

et al. 2024

magn reson med sci

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Section: Future Perspectives and Open Questionsmentioning

confidence: 99%

Tractometry of Human Visual White Matter Pathways in Health and Disease

Takemura,

Kruper,

Miyata

et al. 2024

magn reson med sci

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The effects of the dialysis on the white matter tracts in patients with end-stage renal disease using differential tractography study

Park,

Choi,

Heo

et al. 2023

Sci Rep

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This study aimed to determine whether white matter tracts correlate with kidney function using correlation tractography, and to investigate the effects of dialysis on white matter tracts in patients with end-stage renal disease (ESRD) using differential tractography. Ten patients with ESRD, who had a glomerular filtration rate of < 15 mL/min/1.73 m2, were enrolled in this prospective study. Diffusion tensor imaging (DTI) was performed both before and after dialysis. We discovered that white matter tracts correlated with the estimated glomerular filtration rate based on pre- and post-dialysis DTI using correlation tractography and investigated the differences in the white matter tracts between pre- and post-dialysis DTI in patients with ESRD using differential tractography. Correlation tractography revealed no quantitative anisotropy of the white matter tracts that correlated with the estimated glomerular filtration rate in pre- and post-dialysis patients with ESRD. Differential tractography revealed significant differences in several white matter tracts, particularly the cingulum, thalamic radiation, corpus callosum, and superior longitudinal fasciculus, between pre- and post-dialysis DTI, which revealed increased diffusion density after dialysis. We demonstrated the significant effects of dialysis on several white matter tracts in patients with ESRD using differential tractography, which showed increased diffusion density after dialysis. In this study, we confirmed the effects of dialysis on brain structure, especially white matter tracts.

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Tay-Sachs and Sandhoff Diseases: Diffusion tensor imaging and correlational fiber tractography findings differentiate late-onset GM2 Gangliosidosis

Lewis,

Chipman,

Johnston

et al. 2024

Preprint

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GM2 gangliosidosis is lysosomal storage disorder caused by deficiency of the heterodimeric enzyme β-hexosaminidase A. Tay-Sachs disease is caused by variants inHEXAencoding the α-subunit and Sandhoff disease is caused by variants inHEXBencoding the β-subunit. Due to shared clinical and biochemical findings, the two have been considered indistinguishable. We applied diffusion tensor imaging (DTI) and correlational fiber tractography to assess phenotypic differences in these two diseases. 40 DTI scans from 16 Late-Onset GM2 patients (NCT00029965) with either Sandhoff (n = 4), or Tay-Sachs (n = 12) disease. DTI metrics including fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), axial diffusivity (AD), and quantitative anisotropy (QA) were calculated in fiber tracts throughout the whole brain, arcuate fasciculus, corpus callosum, and cerebellum. Correlational tractography was also performed to identify fiber tracts with group wide differences in DTI metrics between Tay-Sachs and Sandhoff patients. A linear mixed effects model was used to analyze the differences between Tay-Sachs and Sandhoff patients. Tay-Sachs patients had higher MD in the left cerebellum (p= 0.003703), right cerebellum (p= 0.003435), superior cerebellar peduncle (SCP,p= 0.007332), and vermis (p= 0.01007). Sandhoff patients had higher FA in the left cerebellum (p= 0.005537), right cerebellum (p= 0.01905), SCP (p= 0.02844), and vermis (p= 0.02469). Correlational fiber tractography identified fiber tracts almost exclusively in cerebellar pathways with higher FA and QA, and lower MD, AD, and RD in Sandhoff patients compared to Tay-Sachs patients. Our study shows neurobiological differences between these two related disorders. To our knowledge, this is the first study using correlational tractography in a lysosomal storage disorder demonstrating these differences. This result indicates a greater burden of cerebellar pathology in Tay-Sachs patients compared with Sandoff patients.

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Differential and correlational tractography as tract‐based biomarkers in mild traumatic brain injury: A longitudinal MRI study

Cited by 4 publications

References 90 publications

Tractometry of Human Visual White Matter Pathways in Health and Disease

Tractometry of Human Visual White Matter Pathways in Health and Disease

The effects of the dialysis on the white matter tracts in patients with end-stage renal disease using differential tractography study

Tay-Sachs and Sandhoff Diseases: Diffusion tensor imaging and correlational fiber tractography findings differentiate late-onset GM2 Gangliosidosis

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