Differential cellular localization of Epstein–Barr virus and human cytomegalovirus in the colonic mucosa of patients with active or quiescent inflammatory bowel disease

Ciccocioppo, Rachele; Racca, Francesca; Scudeller, Luigia; Piralla, Antonio; Formagnana, Pietro; Pozzi, L.; Betti, E.; Vanoli, Alessandro; Riboni, Roberta; Kružliak, Peter; Baldanti, Fausto

doi:10.1007/s12026-015-8737-y

Cited by 34 publications

(36 citation statements)

References 69 publications

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“…Our investigation reveals a correlation between EBV prevalence in colonic mucosa of IBD patients and clinical disease activities. The rate of EBV positivity increased as clinical disease activities progressed, which is in accordance with Ciccocioppo's study [16]. EBV loads were further analyzed in different groups based on clinical disease activity and we found that EBV loads were higher in the severe group.…”

Section: Discussionsupporting

confidence: 89%

“…It may be due to the difference in patients enrolled. Previous studies showed that mucosal EBV infection is associated with the severity of IBD [16]. In our study, IBD patients recruited are mainly with mild-to-moderate clinical disease activities.…”

Section: Discussionmentioning

confidence: 93%

“…Viral interleukin 10 released by EBV-infected cells potentiates the growth of EBV-transformed cell [23]. Furthermore, Ciccocioppo et al [16] studied EBV cellular localization in IBD patients and found that EBV can infect both B cells and intestinal epithelial cell. In vitro, productive viral replication in epithelial cell is associated with direct cytopathogenic effect [24].…”

Section: Discussionmentioning

confidence: 99%

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The Status of Epstein-Barr Virus Infection in Intestinal Mucosa of Chinese Patients with Inflammatory Bowel Disease

Chen

Peng

et al. 2018

Digestion

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Aims: This cross-sectional study is to investigate the presence of Epstein-Barr virus (EBV) in colonic mucosa of inflammatory bowel disease (IBD) patients and its correlation with the clinical disease activities and therapeutic regimens. Methods: Subjects undergoing colonoscopy for screening of polyps were recruited as control. EBV DNA load was analyzed by means of quantitative real-time polymerase chain reaction and EBV-encoded RNAs were tested by in situ hybridization in intestinal mucosa of IBD patients. EBV infection was defined as positive with either method. Clinical disease activity was assessed using the Mayo Clinic Score for ulcerative colitis and Crohn’s disease activity index for CD. Results: EBV was detectable in 33 out of 99 IBD patients (33.3%). In controls, EBV prevalence was 7.5% (3/40). We found a significant correlation between EBV prevalence and clinical disease activities (mild [10.71%, 3/28] versus moderate [32.73%, 18/55], severe [75.00%, n = 12/16], p < 0.001). However, no significant difference was found in EBV prevalence between patients who received immunosuppressive therapy and those who did not. Conclusions: EBV infection is common in colonic mucosa of IBD patients. There is a significant correlation between EBV infection and clinical disease activities of IBD. However, prospective studies are still needed to explore the exact role of EBV in IBD.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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The Status of Epstein-Barr Virus Infection in Intestinal Mucosa of Chinese Patients with Inflammatory Bowel Disease

Chen

Peng

et al. 2018

Digestion

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“…The study shows that the probability of CMV infection or reactivation in UC population is between 15.8% and 34.0% [8].CMV is an opportunistic virus, which has been biologically characterized by latency and activation [7].CMV infection or reactivation could signi cantly prolong the hospitalization period, increase the Corticosteroids dependence rate, operation rate and mortality [9]. The reason may be that CMV infection or reactivation could aggravate the in ammatory response and immune process, exacerbating colon damage [10]. At present, the researchers believe that CMV infection or reactivation is an independent risk factor for UC patients [11].…”

Section: Introductionmentioning

confidence: 99%

Risk factors of cytomegalovirus infection or reactivation in ulcerative colitis patients

Qin¹,

Dejun²,

Wang³

et al. 2020

Preprint

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Background To identify the risk factors for cytomegalovirus (CMV)infection or reactivation in ulcerative colitis (UC) patients. Method PubMed, Cochrane Library, EMBASE, Web of Science and CNKI were retrieved from the inception of electronic databases to February 2020. All analyses were performed using Stata/SE 15.1 version (StataCorp). Result 22 papers were included. There was significant difference in severe UC (OR = 1.465, 95% CI: 1.107 to 1.939, P = 0.008), pancolitis (OR = 2.108, 95% CI: 1.586 to 2.800, P = 0.0001), age of onset (MD = 6.212, 95% CI: 2.552 to 9.971, P = 0.001), glucocorticoid (OR = 4.175, 95% CI: 3.076 to 5.666, P = 0.001), immunosuppressant (OR = 2.038, 95% CI: 1.259 to 3.301, P = 0.004), 5-ASA (OR = 0.674, 95% CI: 0.492 to 0.924, P = 0.014). However, no significant difference was detected in disease duration, infliximab. Conclusion Severe UC, pancolitis, glucocorticoid, immunosuppressive therapy and age of onset are the risk factors of CMV infection or reactivation in UC patients, we should closely monitor if UC patients with the above indicators and give timely symptomatic treatment to prevent the disease from worsening.

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“…Y. Li et al conducted a 5-year retrospective study in IBD patients, the result of which was a conclusion that in mixed infection (CMV and C.difficile), worse outcomes are observed in patients with UC and CD [8]. Cytomegalovirus disease in patients with IBD is often a result of viral reactivation against the background of ongoing immunosuppression [9][10][11][12][13]. C. Rowan et al (2018) recommend diagnostic tests to be carried out for the detection of CMV markers in all patients with IBD occurring with febrile condition [9].…”

Section: Introductionmentioning

confidence: 99%

Цитомегаловирусная И Смешанные Вирусные Инфекции У Пациентов С Воспалительными Заболеваниями Кишечника

Babayeva¹

2021

GASTRO

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Background. The issue of the prevalence of opportunistic infections in persons with inflammatory bowel disease (IBD) remains relevant. Among opportunistic infections, in particular, we would like to note Herpesviridae family (herpes simplex virus type 1 and 2), human herpesvirus type 3 (varicella zoster virus), human herpesvirus type 4 (Epstein-Barr virus), cytomegalovirus (CMV), or human herpesvirus type 5, human herpesvirus type 6 and parvovirus B19. Clinically marked herpes and parvovirus infections are frequent causes of systemic inflammation of the gastrointestinal tract. This is a serious problem, especially for persons with long-term immunosuppression, who have IBD, and special attention in this aspect is paid to cytomegalovirus infection. Clinical activity of CMV-associated IBD, its duration and severity, as well as the use of steroids and anti-TNF-α agents were identified as risk factors for adverse outcomes. It is important not only to detect the presence of viruses in the patient's body, but also to clarify their etiological role in the development of the disease. According to the current European Crohn's and Colitis Organisation (ECCO) protocols, all patients with IBD are recommended to be screened in hormone resistance, loss of effect from maintenance therapy and severe attacks of the disease. The addition of active CMV infection to IBD may likely be one of the causes of resistance to hormone and immunosuppressive therapy, as well as biological drugs, but this issue requires further researches. The purpose was to evaluate the frequency of detecting isolated cytomegalovirus infection and mixed (herpes and parvovirus B19) viral infections in patients with IBD and their influence on the disease activity. Materials and methods. One hundred and eightynine patients (98 women and 91 men) with IBD (102 with ulcerative colitis (UC) and 87 with Crohn's disease (CD)) were examined. The age of patients was from 16 to 63 years (mean age (41.4 ± 4.8) years). In addition to standard clinical endoscopic examinations according to ECCO guidelines, disease activity was assessed by indicators of highly sensitive C-reactive protein, homocysteine, vitamin D in blood serum, albumin in urine, calprotectin and lactoferrin in feces. All patients underwent serological blood test by enzyme-linked immunosorbent assay for specific antibodies to herpesviruses and IgG/IgM antibodies to parvovirus B19, determination of DNA of herpes simplex viruses types 1, 2, 6, Epstein-Barr virus, cytomegalovirus, herpes zoster by a polymerase chain reaction in blood and tissues. All patients underwent determination of blood cytokines (tumor necrosis factor α,

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Differential cellular localization of Epstein–Barr virus and human cytomegalovirus in the colonic mucosa of patients with active or quiescent inflammatory bowel disease

Cited by 34 publications

References 69 publications

The Status of Epstein-Barr Virus Infection in Intestinal Mucosa of Chinese Patients with Inflammatory Bowel Disease

The Status of Epstein-Barr Virus Infection in Intestinal Mucosa of Chinese Patients with Inflammatory Bowel Disease

Risk factors of cytomegalovirus infection or reactivation in ulcerative colitis patients

Цитомегаловирусная И Смешанные Вирусные Инфекции У Пациентов С Воспалительными Заболеваниями Кишечника

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