Differential changes in platelet reactivity induced by acute physical compared to persistent mental stress

Hüfner, Katharina; Koudouovoh-Tripp, Pia; Kandler, Christina; Hochstrasser, Tanja; Malík, Peter; Giesinger, Johannes M.; Semenitz, Barbara; Humpel, Christian; Sperner‐Unterweger, Barbara

doi:10.1016/j.physbeh.2015.07.021

Cited by 8 publications

(6 citation statements)

References 67 publications

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“…Interestingly, platelets not only contribute to the progression of depression, but also play a role in stress. In two previous papers we reported on differential changes in platelets reactivity induced by acute physical stress compared to persistent mental stress and also showed that stress enhances pro-inflammatory platelets activity [47,48]. This present study shows that tau protein levels are decreased in depressed people followed by a slight enhanced phospho-tau-181 activation.…”

Section: Discussionsupporting

confidence: 71%

Platelet TAU is Associated with Changes in Depression and Alzheimer's Disease

Sarg

Korde

Marksteiner

et al. 2022

Front. Biosci. (Landmark Ed)

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Background: Platelets (thrombocytes) are small anuclear cells that play an important role in blood clotting. They are activated and dysfunctional in brain disorders, such as Alzheimer’s disease (AD) and depression. Platelets express the amyloid-precursor protein (APP) and release beta-amyloid40 into the blood. Recent evidence reports that platelets also express the microtubule-associated protein tau. In this study, we further characterized the molecular appearance of tau and examined its alterations in patients with neurocognitive impairment. Methods: Platelets were isolated from patients with AD, mild cognitive impairment (MCI) or depression and compared to healthy controls. Subsequently, FACS analysis was employed to characterize platelets for platelet surface P-selectin (CD62P). In order to enhance the detection levels, samples were pooled (15 samples per group) and analyzed by Lumipulse Assay, Western blots, and mass spectrometry. Results: Tau is expressed in human platelets and tau levels were decreased in platelets isolated from patients with AD and depression. Additionally, phospho-tau-181 was slightly increased in patients with depression. We show that tau is highly fragmented (20–40 kDa) in the platelet extracts using Western blot analysis. The mass spectrometry data did not show a clear identification of tau in the pooled platelet samples. Conclusions: Our data reveal that tau is found in platelets, possibly in a highly fragmented form. Tau levels may be used as a potential diagnostic approach to differentiate AD and depression from healthy controls.

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Section: Discussionsupporting

confidence: 71%

Platelet TAU is Associated with Changes in Depression and Alzheimer's Disease

Sarg

Korde

Marksteiner

et al. 2022

Front. Biosci. (Landmark Ed)

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“…MMP-9 is found mainly in the cytosol of platelets. No group differences between major depressive disorders and controls were found for MMP-9 in platelets (58). Chiarani et al recruited 20 patients with bipolar disorder and 20 control subjects that were matched for age and sex.…”

Section: Mmp-9 As a Biomarker For Depressionmentioning

confidence: 99%

Matrix Metalloproteinase-9 as an Important Contributor to the Pathophysiology of Depression

Sheng

Khan

et al. 2022

Front. Neurol.

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Matrix metalloproteinases (MMPs) are physiologically expressed in the central nervous system in neurons, astrocytes and microglia, and their aberrant elevation contributes to a number of diseases. Amongst the MMP members, MMP−9 has generated considerable attention because of its possible involvement in inflammatory responses, blood-brain barrier permeability, the regulation of perineuronal nets, demyelination, and synaptic long-term potentiation. Emerging evidence indicate an association between MMP−9 and the syndrome of depression. This review provides an updated and comprehensive summary of the probable roles of MMP−9 in depression with an emphasis on the mechanisms and potential of MMP−9 as a biomarker of depression.

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“…Studies investigating the comorbidity between cardiovascular disease and depression have proposed platelet serotonin signaling as a potential mechanism for the higher incidence of cardiac adverse events in depressed cardiovascular patients ( 76 ). Additionally, other studies have suggested that altered platelet reactivity might link stress, depression, and cardiovascular disease through changes in platelet aggregability and their content of bioactive compounds ( 77 , 78 ). Platelet activation has also been implicated as a contributor to the progression of neurological conditions such as Alzheimer’s disease ( 79 ).…”

Section: Discussionmentioning

confidence: 99%

Depression proteomic profiling in adolescents with transcriptome analyses in independent cohorts

Sokolov,

Lafta,

Nordberg

et al. 2024

Front. Psychiatry

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IntroductionDepression is a major global burden with unclear pathophysiology and poor treatment outcomes. Diagnosis of depression continues to rely primarily on behavioral rather than biological methods. Investigating tools that might aid in diagnosing and treating early-onset depression is essential for improving the prognosis of the disease course. While there is increasing evidence of possible biomarkers in adult depression, studies investigating this subject in adolescents are lacking.MethodsIn the current study, we analyzed protein levels in 461 adolescents assessed for depression using the Development and Well-Being Assessment (DAWBA) questionnaire as part of the domestic Psychiatric Health in Adolescent Study conducted in Uppsala, Sweden. We used the Proseek Multiplex Neuro Exploratory panel with Proximity Extension Assay technology provided by Olink Bioscience, followed by transcriptome analyses for the genes corresponding to the significant proteins, using four publicly available cohorts.ResultsWe identified a total of seven proteins showing different levels between DAWBA risk groups at nominal significance, including RBKS, CRADD, ASGR1, HMOX2, PPP3R1, CD63, and PMVK. Transcriptomic analyses for these genes showed nominally significant replication of PPP3R1 in two of four cohorts including whole blood and prefrontal cortex, while ASGR1 and CD63 were replicated in only one cohort.DiscussionOur study on adolescent depression revealed protein-level and transcriptomic differences, particularly in PPP3R1, pointing to the involvement of the calcineurin pathway in depression. Our findings regarding PPP3R1 also support the role of the prefrontal cortex in depression and reinforce the significance of investigating prefrontal cortex-related mechanisms in depression.

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Differential changes in platelet reactivity induced by acute physical compared to persistent mental stress

Cited by 8 publications

References 67 publications

Platelet TAU is Associated with Changes in Depression and Alzheimer's Disease

Platelet TAU is Associated with Changes in Depression and Alzheimer's Disease

Matrix Metalloproteinase-9 as an Important Contributor to the Pathophysiology of Depression

Depression proteomic profiling in adolescents with transcriptome analyses in independent cohorts

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