2022
DOI: 10.1016/j.brainresbull.2022.06.019
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Differential contribution of estrogen receptors to the intestinal therapeutic effects of 17β-estradiol in a murine model of Parkinson’s disease

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Cited by 5 publications
(5 citation statements)
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“…Additionally, GPER1 agonist G-1 is protective against inflammation through macrophage modulation in various neuro-diseases, including multiple sclerosis [ 40 ], Parkinson’s disease [ 41 , 42 ], and traumatic brain injury [ 43 ]. A recent publication in Science revealed that G-1 might preserve fetal health via INF signaling regulation in maternal tissues [ 44 ].…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, GPER1 agonist G-1 is protective against inflammation through macrophage modulation in various neuro-diseases, including multiple sclerosis [ 40 ], Parkinson’s disease [ 41 , 42 ], and traumatic brain injury [ 43 ]. A recent publication in Science revealed that G-1 might preserve fetal health via INF signaling regulation in maternal tissues [ 44 ].…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, past clinical studies predominantly focus on the role of estrogen, and its potential protective role against the process of alpha-synucleinopathy, the argument for this is somewhat supported by higher incidence of PD in peri/and menopausal period ( 168 , 169 , 261 ). In preclinical studies, oestradiol and progesterone manipulation in ovariectomised, or gonadectomised mice, has demonstrated distinct sex differences in multiple aspects of alpha-synucleinopathy process ( 17 , 262 267 ). Importantly, several of these animal models suggest that estrogen deprivation may results in dopaminergic neuron loss and lower dopaminergic binding ( 268 ).…”
Section: Discussionmentioning
confidence: 99%
“…Cumulative evidence has reported higher prevalence, incidence, increased disease severity and susceptibility of men compared with women in alpha-synucleinopathies such as PD (10), MSA (11,12) and DLB (13), and even in the prodromal stage of alpha-synucleinopathies such as REM Behavior Disorder (RBD) (14). To address this, animal and clinical studies have posited the notion of neuroprotective properties of the female sex hormone estrogen against alphasynucleinopathies (15)(16)(17)(18). However, asserting any causality to estrogen as a protective factor in alpha-synucleinopathies remains speculative without a thorough investigation into the observable…”
Section: Introductionmentioning
confidence: 99%
“…As a member of the nuclear receptors family, the estrogen receptor (ESR1) typically functions as a ligand-activated transcription factor. The binding of ligands induces conformational changes in receptors, leading to translocations into the nucleus and transcriptional activation of some target genes (Poirier et al, 2022). ESR1 affects the ligand-binding domains of these proteins.…”
Section: Molecular Docking Of Bioactive Substances Of Interest To The...mentioning
confidence: 99%