Differential Contributions of Prefrontal and Hippocampal Dopamine D<sub>1</sub>and D<sub>2</sub>Receptors in Human Cognitive Functions

Takahashi, Hidehiko; Kato, Masaaki; Takano, Harumasa; Arakawa, Ryosuke; Okumura, Masaki; Otsuka, Tatsui; Kodaka, Fumitoshi; Hayashi, Mitsuko; Okubo, Yoshiro; Ito, Hiroshi; Suhara, Tetsuya

doi:10.1523/jneurosci.3446-08.2008

Cited by 158 publications

(136 citation statements)

References 57 publications

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“…11 C]SCH23390 and [ 11 C]FLB457 studies (Cervenka et al, 2006;Takahashi et al, 2008;Karlsson et al, 2009;McNab et al, 2009), a very small region or a single voxel is susceptible to partial volume effect. Thus, it is recommended that parametric image analysis should be used in combination with ROI analysis.…”

Section: Discussionmentioning

confidence: 99%

Contribution of Dopamine D1 and D2 Receptors to Amygdala Activity in Human

Takahashi¹,

Takano²,

Kodaka³

et al. 2010

J. Neurosci.

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Several animal studies have demonstrated functional roles of dopamine (DA) D1 and D2 receptors in amygdala activity. However, the contribution of DA D1 and D2 receptors to amygdala response induced by affective stimuli in human is unknown. To investigate the contribution of DA receptor subtypes to amygdala reactivity in human, we conducted a multimodal in vivo neuroimaging study in which DA D1 and D2 receptor bindings in the amygdala were measured with positron emission tomography (PET), and amygdala response induced by fearful faces was assessed by functional magnetic resonance imaging (fMRI) in healthy volunteers. We used multimodality voxelwise correlation analysis between fMRI signal and DA receptor binding measured by PET. DA D1 binding in the amygdala was positively correlated with amygdala signal change in response to fearful faces, but DA D2 binding in the amygdala was not related to amygdala signal change. DA D1 receptors might play a major role in enhancing amygdala response when sensory inputs are affective.

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Section: Discussionmentioning

confidence: 99%

Contribution of Dopamine D1 and D2 Receptors to Amygdala Activity in Human

Takahashi¹,

Takano²,

Kodaka³

et al. 2010

J. Neurosci.

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“…Enhanced dopamine levels are found in early PD patients resulting in impaired prefrontal functioning [34][35][36] presumably due to frontal compensation [37]. With disease progression, the number of prefrontal D1-like receptors is reduced and prefrontal functioning deteriorates [36,[38][39][40].…”

Section: A)b) Dopaminementioning

confidence: 99%

Parkinson's disease, visual hallucinations and apomorphine: A review of the available evidence

Borgemeester

Lees²,

Laar

2016

Parkinsonism & Related Disorders

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“…DA prolongs long-term potentiation (LTP; Frey et al, 1990Frey et al, , 1993Huang and Kandel, 1995), a cellular mechanism necessary for successful memory formation and consolidation (for review, see Cooke and Bliss, 2006). In humans, molecular imaging studies have related higher D2 receptor binding in hippocampus to better recall of verbal (Takahashi et al, 2007) and pictorial (Takahashi et al, 2008) memory. Relatedly, striatal D2 receptor density has been associated with better performance across different episodic memory tasks (Bäckman et al, 2000;Cervenka et al, 2008).…”

Section: Dopaminergic Modulation Of Episodic Memorymentioning

confidence: 99%

Dopamine and glutamate receptor genes interactively influence episodic memory in old age

Papenberg¹,

Li²,

Nagel³

et al. 2014

Neurobiology of Aging

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a b s t r a c tBoth the dopaminergic and glutamatergic systems modulate episodic memory consolidation. Evidence from animal studies suggests that these two neurotransmitters may interact in influencing memory performance. Given that individual differences in episodic memory are heritable, we investigated whether variations of the dopamine D2 receptor gene (rs6277, C957T) and the N-methyl-D-aspartate 3A (NR3A) gene, coding for the N-methyl-D-aspartate 3A subunit of the glutamate N-methyl-D-aspartate receptor (rs10989591, Val362Met), interactively modulate episodic memory in large samples of younger (20e31 years; n ¼ 670) and older (59e71 years; n ¼ 832) adults. We found a reliable gene-gene interaction, which was observed in older adults only: older individuals carrying genotypes associated with greater D2 and N-methyl-D-aspartate receptor efficacy showed better episodic performance. These results are in line with findings showing magnification of genetic effects on memory in old age, presumably as a consequence of reduced brain resources. Our findings underscore the need for investigating interactive effects of multiple genes to understand individual difference in episodic memory.

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Differential Contributions of Prefrontal and Hippocampal Dopamine D₁and D₂Receptors in Human Cognitive Functions

Cited by 158 publications

References 57 publications

Contribution of Dopamine D1 and D2 Receptors to Amygdala Activity in Human

Contribution of Dopamine D1 and D2 Receptors to Amygdala Activity in Human

Parkinson's disease, visual hallucinations and apomorphine: A review of the available evidence

Dopamine and glutamate receptor genes interactively influence episodic memory in old age

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Differential Contributions of Prefrontal and Hippocampal Dopamine D1and D2Receptors in Human Cognitive Functions

Cited by 158 publications

References 57 publications

Contribution of Dopamine D1 and D2 Receptors to Amygdala Activity in Human

Contribution of Dopamine D1 and D2 Receptors to Amygdala Activity in Human

Parkinson's disease, visual hallucinations and apomorphine: A review of the available evidence

Dopamine and glutamate receptor genes interactively influence episodic memory in old age

Contact Info

Product

Resources

About

Differential Contributions of Prefrontal and Hippocampal Dopamine D₁and D₂Receptors in Human Cognitive Functions