Differential correlations between plasma oxytocin and social cognitive capacity and bias in schizophrenia

Walss‐Bass, Consuelo; Fernandes, João Miguel; Roberts, David L.; Velligan, Dawn I.

doi:10.1016/j.schres.2013.04.003

Cited by 52 publications

(44 citation statements)

References 59 publications

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“…It is also known that the patients with SCH have a deficit in the amygdala, the prefrontal cortex and the dopaminergic systems [56,57]. The lack of correlation between the blood levels of OT and social cognitive capacity in patients with SCH, in our study, can be explained by the deficits in these systems.…”

Section: Discussioncontrasting

confidence: 53%

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Oxytocin and social cognition in patients with schizophrenia: comparison with healthy siblings and healthy controls

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Taş

et al. 2017

Psychiatry and Clinical Psychopharmacology

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Objective: There is substantial evidence from animal research indicating a key role of the neuropeptide oxytocin (OT) in the regulation of complex social cognition and behaviour. Social cognition is indispensable for social relationships for the whole of human society, and numerous studies have shown impaired social cognition in schizophrenia (SCH) and unaffected first-degree relatives also seem to be impaired, albeit to a lesser extent. Because of that, this study focuses on the role of OT in social cognition in SCH. Methods: Twenty-seven patients with SCH, 27 healthy siblings (HS) of these patients, and 27 psychologically healthy controls (HC) were included in the study. Blood samples were collected through a peripheral venous catheter. Differences in the socio-demographical and WAIS-R were tested by chi-square and one way-ANOVA. To explore the relationships between social cognition and blood samples we performed Pearson correlations. MANCOVA (gender and WAIS-R as covariates) test was performed to investigate the effect of gender on blood levels of OT and WAIS-R on social cognition. Results: Significant differences were found in neurocognitive and social cognitive capacity but not in OT levels. In the healthy control group, there was a positive correlation between blood OT levels and RMET. There is a statistically significant difference between high and low OT groups with regard to social cognition in all subtests of the RMET. Conclusions: In the current study, we found that patients had deficits in social cognition and neurocognition. Lower endogenous OT levels are also predictive for poor social cognitive functioning in HS and HC.ARTICLE HISTORY

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Section: Discussioncontrasting

confidence: 53%

“…The amygdala, the prefrontal cortex, and dopaminergic systems have a mediator role in oxytocinergic system [56,57]. It is also known that the patients with SCH have a deficit in the amygdala, the prefrontal cortex and the dopaminergic systems [56,57].…”

Section: Discussionmentioning

confidence: 99%

Oxytocin and social cognition in patients with schizophrenia: comparison with healthy siblings and healthy controls

Balıkçı

Aydın

Taş

et al. 2017

Psychiatry and Clinical Psychopharmacology

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“…There is inconsistency among findings, with some studies reporting that people with schizophrenia who are polydipsic have lower endogenous oxytocin levels than healthy controls (Goldman et al, 2008; Goldman et al, 2011), some reporting higher levels in people with schizophrenia (Beckmann et al, 1985), and others reporting no group differences (Rubin et al, 2014; Rubin et al, 2013; Rubin et al, 2011; Rubin et al, 2010). Furthermore, lower endogenous oxytocin has been associated with greater severity of positive and negative symptoms, poor social functioning, impaired facial affect perception, abnormal judgment of gaze direction, and impaired theory of mind (Goldman et al, 2008; Keri et al, 2009; Rubin et al, 2011; Rubin et al, 2010; Walss-Bass et al, 2013). Acute challenge and multi-dose clinical trials have produced inconsistent results (Horta de Macedo et al, 2014; Lee et al, 2013); however, there is some evidence that intranasal administration of oxytocin improves psychiatric symptoms and social cognition (Averbeck et al, 2012; Davis et al, 2014; Davis et al, 2013; Feifel et al, 2010; Fischer-Shofty et al, 2013a; Fischer-Shofty et al, 2013b; Gibson et al, 2014; Pedersen et al, 2011; Woolley et al, 2014), as well as olfactory identification (Lee et al, 2013).…”

Section: 0 Introductionmentioning

confidence: 99%

Plasma oxytocin levels predict olfactory identification and negative symptoms in individuals with schizophrenia

Strauss

Keller

Koenig

et al. 2015

Schizophrenia Research

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Basic neuroscience research provides strong evidence for the role of oxytocin in olfactory processes and social affiliation in rodents. Given prior indication of olfactory impairments that are linked to greater severity of asociality in schizophrenia, we examined the association between plasma oxytocin levels and measures of olfaction and social outcome in a sample of outpatients with schizophrenia (n = 39) and demographically matched healthy controls (n = 21). Participants completed the 40-item University of Pennsylvania Smell Identification Test (UPSIT), and rated each odor for how positive and how negative it made them feel. Results indicated that individuals with schizophrenia had higher plasma oxytocin levels and lower overall accuracy for UPSIT items than controls. Individuals with schizophrenia also reported experiencing more negative emotionality than controls in response to the olfactory stimuli. Lower plasma oxytocin levels were associated with poorer accuracy for pleasant and unpleasant odors and greater severity of asociality in individuals with schizophrenia. These findings suggest that endogenous oxytocin levels may be an important predictor of olfactory identification deficits and negative symptoms in schizophrenia.

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“…Twelve studies to date have measured peripheral OXT levels in schizophrenia-spectrum samples (see Table 1). These studies show plasma (or CSF) OXT levels to be significantly reduced (Jobst et al, 2014), significantly increased (Beckmann et al, 1985;Legros et al, 1992;Walss-Bass et al, 2013), or no different (Glovinsky et al, 1994;Sasayama et al, 2012;Rubin et al, 2013), in patients compared to healthy controls. These mixed findings are possibly due to confounding effects of sex and antipsychotic medications.…”

Section: Behavioural Effects Of Oxytocin In Schizophrenia-spectrum DImentioning

confidence: 90%

“…These mixed findings are possibly due to confounding effects of sex and antipsychotic medications. To add to these inconsistent results, higher OXT levels have been linked to better facial emotion recognition (Goldman et al, 2008), worse performance on a ToM measure (Walss-Bass et al, 2013), more pro-social behaviours (Rubin et al, 2010;Jobst et al, 2014), less severe negative symptoms (Keri et al, 2009;Sasayama et al, 2012), and presence of delusions (Walss-Bass et al, 2013). Importantly, these studies differed greatly in the sample characteristics, methodology and outcome measures used (see Table 1 for further details).…”

Section: Behavioural Effects Of Oxytocin In Schizophrenia-spectrum DImentioning

confidence: 99%

Effects of oxytocin and genetic variants on brain and behaviour: Implications for treatment in schizophrenia

Bartholomeusz

Ganella

Labuschagne

et al. 2015

Schizophrenia Research

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Differential correlations between plasma oxytocin and social cognitive capacity and bias in schizophrenia

Cited by 52 publications

References 59 publications

Oxytocin and social cognition in patients with schizophrenia: comparison with healthy siblings and healthy controls

Oxytocin and social cognition in patients with schizophrenia: comparison with healthy siblings and healthy controls

Plasma oxytocin levels predict olfactory identification and negative symptoms in individuals with schizophrenia

Effects of oxytocin and genetic variants on brain and behaviour: Implications for treatment in schizophrenia

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