Differential cytotoxic effects of arsenic compounds in human acute promyelocytic leukemia cells

Enzyme-assisted extraction and liquid chromatography mass spectrometry for the determination of arsenic species in chicken meat

“…Arsenic in food can range from highly toxic inorganic arsenite to the virtually non-toxic arsenobetaine. Even among the commonly encountered toxic arsenic species, their relative toxicity, e.g., in terms of medium lethal concentration (LC 50 ), varies by 3-4 orders of magnitude [13][14][15][16][17], with arsenite (LC 50 = 2.3 mM) being much more cytotoxic than dimethylarsinic acid (LC 50 = 1680 mM), tested on HL60 cells [14]. Therefore, the determination of total arsenic in food is not sufficient for human health risk assessment; it is necessary to determine the speciation of arsenic in food.…”

Implementation of an Analytical Method for the Determination of Inorganic Arsenic Species in Occupationally Exposed Human Urine Samples and Its Toxic Effects on Epithelial Cells of Renal Collecting Tubule

“…In this study, Pereira et al, reported that As (III) caused a loss of endothelial monolayer integrity in HAECs (human aortic endothelial cells) exposed to 1.5 and 10 mM As (III) over 1, 6, 12 and 24 hour treatment times and described the formation of actin stress fibers 26 . Furthermore HL-60 cells (leukemia cells) exposed to As (III) over 48 hours showed morphological changes 27 . Figure 5.…”

Role of autophagy in the progression and suppression of leukemias

“…Arsenic tri-oxide is another compound which was shown to induce cell death in APL cells via autophagy [89,90]. However some other arsenicals did not show tumor suppressive effects by activation of the autophagic pathway in a promyelocytic leukemia cell line [91]. Epigenetic alterations were also found to be important for inducing cell death through autophagy.…”