Differential developmental programming by early protein restriction of rat skeletal muscle according to its fibre‐type composition

Aragão, Raquel da Silva; Guzmán-Quevedo, Omar; Pérez-García, Georgina; Toscano, Ana Elisa; Leandro, Carol Góis; Manhães-de-Castro, Raul; Bolaños-Jiménez, Francisco

doi:10.1111/apha.12073

Cited by 17 publications

(11 citation statements)

References 56 publications

(103 reference statements)

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“…The effect of maternal protein restriction during pregnancy and lactation on fiber-type composition of skeletal muscle in rats was studied by da Silva et al Rats fed a normal protein diet (17% protein) exhibited enhanced density of type II fibers along with a decreased rate of fatty acid oxidation and glycolysis in the soleus but not the extensor digitorum longus (EDL) in the lower leg compared with rats that were fed a low protein diet (7%). Authors suggested that protein restriction alters the structure and enzymatic properties of skeletal muscle with a potential role in the development of obesity and its comorbidities as fiber-type composition of skeletal muscle is associated with obesity and insulin resistance [ 78 ].…”

Section: Maternal Protein Intake and Fetal Programmingmentioning

confidence: 99%

The Role of Maternal Dietary Proteins in Development of Metabolic Syndrome in Offspring

et al. 2015

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The prevalence of metabolic syndrome and obesity has been increasing. Pre-natal environment has been suggested as a factor influencing the risk of metabolic syndrome in adulthood. Both observational and experimental studies showed that maternal diet is a major modifier of the development of regulatory systems in the offspring in utero and post-natally. Both protein content and source in maternal diet influence pre- and early post-natal development. High and low protein dams’ diets have detrimental effect on body weight, blood pressure191 and metabolic and intake regulatory systems in the offspring. Moreover, the role of the source of protein in a nutritionally adequate maternal diet in programming of food intake regulatory system, body weight, glucose metabolism and blood pressure in offspring is studied. However, underlying mechanisms are still elusive. The purpose of this review is to examine the current literature related to the role of proteins in maternal diets in development of characteristics of the metabolic syndrome in offspring.

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Section: Maternal Protein Intake and Fetal Programmingmentioning

confidence: 99%

The Role of Maternal Dietary Proteins in Development of Metabolic Syndrome in Offspring

et al. 2015

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“…It is also estimated that foetal undernutrition causes mitochondrial dysfunction (Reusens et al 2011b), as well as telomere shortening (Tarry-Adkins et al 2009) in the pancreas resulting in lower energy synthesis and an inadequate antioxidant balance which might consequently lead to metabolic syndrome. Recent studies have linked changes in the skeletal as well as cardiac muscle composition with later cardiovascular pathogenesis (Tarry-Adkins et al 2013;da Silva Aragao et al 2014). The above changes demonstrate that early nutrition might have a dramatic impact on all organ systems at a cellular as well as the subcellular level.…”

Section: Discussionmentioning

confidence: 99%

Maternal Caloric Restriction prior to Pregnancy Increases the Body Weight of the Second-Generation Male Offspring and Shortens Their Longevity in Rats

Araminaitė

Žalgevičienė

Simkunaite-Rizgeliene

et al. 2014

Tohoku J. Exp. Med.

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Maternal undernutrition can affect offspring's physical status and various health parameters that might be transmittable across several generations. Many studies have focused on undernutrition throughout pregnancy, whereas maternal undernutrition prior to pregnancy is not sufficiently studied. The objective of our study was to explore the effects of food restriction prior to and during pregnancy on body weight and longevity of the second generation offspring. Adult female Wistar rats ("F0" generation) were 50% food restricted for one month prior to pregnancy (pre-pregnancy) or during pre-pregnancy and pregnancy. The third group was fed normally (control). The first generation offspring were normally fed until the 6 th month of age to produce the second generation offspring; namely, the first-generation female rats were mated with male breeders from outside the experiment. The second generation offspring thus obtained were observed until natural death (up to 36 months). Compared to the controls, the second-generation male offspring whose "grandmothers (F0 females)" undernourished only during pre-pregnancy were significantly heavier from the 8 th month of age, whereas no significant weight difference was found in the male offspring whose "grandmothers" were food-restricted during pre-pregnancy and pregnancy. Shorter lifespan was observed in the second-generation male offspring of "grandmothers" that were food-restricted either during pre-pregnancy or during pre-pregnancy and pregnancy. By contrast, no differences in body weight and lifespan were observed in all second-generation female offspring. In conclusion, maternal caloric restriction prior to pregnancy increases the body weight and shortens the longevity of the second-generation male offspring, indicating the sex-dependent transgenerational effect of maternal caloric restriction.

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“…However, other authors have shown that muscle fibers are capable of adapting their metabolism, optimizing protein turnover to preserve the primary functions in malnutrition conditions [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Higher insulin sensitivity in EDL muscle of rats fed a low-protein, high-carbohydrate diet inhibits the caspase-3 and ubiquitin-proteasome proteolytic systems but does not increase protein synthesis

Santos

Batistela

Pereira

et al. 2016

The Journal of Nutritional Biochemistry

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+ 55 to 65 to 3615 to 8765; Fax: +55 to 65 to 3615 to 8005. E-mail address: nairhonda@terra.com.br (N. H. Kawashita). AbstractCompared with the extensor longus digitorum (EDL) muscle of control rats (C), the EDL muscle of rats fed a low-protein, high-carbohydrate (LPHC) diet showed a 36% reduction in mass. Muscle mass is determined by the balance between protein synthesis and proteolysis; thus, the aim of this work was to evaluate the components involved in these processes. Compared with the muscle from C rats, the EDL muscle from LPHC diet-fed rats showed a reduction (34%) in the in vitro basal protein synthesis and a 22% reduction in the in vitro basal proteolysis suggesting that the reduction in the mass can be associated with a change in the rate of the two processes. Soon after euthanasia, in the EDL muscles of the rats fed the LPHC or C diet for 15 days, the activity of caspase-3 and of components of the ubiquitin-proteasome system (atrogin-1 content and chymotrypsin-like activity) were decreased. The phosphorylation of p70 S6K and 4E-BP1, proteins involved in protein synthesis, was also decreased. We observed an increase in the insulin-stimulated protein content of p-Akt. Thus, the higher insulin sensitivity in the EDL muscle of LPHC rats seemed to contribute to the lower proteolysis in LPHC rats. However, even with the higher insulin sensitivity, the reduction in p-E4-BP1 and p70 S6Kindicates a reduction in protein synthesis, showing that factors other than insulin can have a greater effect on the control of protein synthesis.

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Differential developmental programming by early protein restriction of rat skeletal muscle according to its fibre‐type composition

Cited by 17 publications

References 56 publications

The Role of Maternal Dietary Proteins in Development of Metabolic Syndrome in Offspring

The Role of Maternal Dietary Proteins in Development of Metabolic Syndrome in Offspring

Maternal Caloric Restriction prior to Pregnancy Increases the Body Weight of the Second-Generation Male Offspring and Shortens Their Longevity in Rats

Higher insulin sensitivity in EDL muscle of rats fed a low-protein, high-carbohydrate diet inhibits the caspase-3 and ubiquitin-proteasome proteolytic systems but does not increase protein synthesis

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