Differential Diagnosis for Intrahepatic Biliary Cystadenoma and Hepatic Simple Cyst

Choi, Hyo Kyung; Lee, Jong Kyun; Lee, Kwang Hyuck; Lee, Kyu Taek; Rhee, Jong Chul; Kim, Kap Hyun; Jang, Kyung Mi; Kim, Seong Hyun; Park, Yulri

doi:10.1097/mcg.0b013e3181b5c789

Cited by 90 publications

(38 citation statements)

References 10 publications

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“…On ultrasound, cystic nature of the lesion with multiple loculi, septations, and internal echoes, with papillary projections [9, 15], is typical. The cyst is well-demarcated and thick-walled, globular or ovoid with a noncalcified wall [7–9, 27]. Doppler study may show the vascular flow within the lesion [28].…”

Section: Discussionmentioning

confidence: 99%

Biliary Cystadenomas: A Case for Complete Resection

et al. 2012

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Introduction and Objective. Biliary cystadenoma is a rare benign neoplasm of the liver with less than 200 cases being reported allover the world. We report a series of 13 cases highlighting the radiological findings and problems related to its management. Materials and Methods. Records of thirteen patients who underwent surgery for biliary cystadenomas, between March 2006 and October 2011, were reviewed retrospectively. Results. Majority of the patients were females (11 out of 13), with a median age of 46 (23–65) years. The most frequent symptom was abdominal pain (92%). Seven patients had presented with history of previous surgery for liver lesions. Five patients had presented with recurrence after partial resection for a suspected hydatid cyst and two after surgery for presumed simple liver cyst. Ten of the 13 patients had complete resection of the cyst with enucleation in 3 patients, 2 of whom in addition required T-tube drainage of the bile duct. There has been no recurrence during the follow-up period ranging from 3 months to 5 years. Conclusion. Biliary cystadenoma must be differentiated from other benign cysts. Hepatic resection or cyst enucleation is the recommended treatment option.

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Section: Discussionmentioning

confidence: 99%

Biliary Cystadenomas: A Case for Complete Resection

et al. 2012

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“…(56) Simple hepatic cysts have a better-defined tissue/fluid interface on imaging than BCT (Figure 3) . (57) In addition, Choi and colleagues (58) identified the presence of a septum and septal thickening as significant predictors of BCA versus simple hepatic cysts in their series of 31 patients. Echinococcal cyst and liver abscesses are the two other cystic liver lesions that sometimes can be difficult to differentiate from BCTs.…”

Section: Imagingmentioning

confidence: 99%

“…The role of cyst fluid CEA, CA19-9, and serum tumor markers remains controversial. (45, 56, 58, 70) Although many providers may obtain a CA19-9, the sensitivity and specificity are not high enough to differentiate a BCA from a BCAC. Moreover, fine needle aspiration (FNA) of suspected BCAC has been associated with pleural and peritoneal dissemination.…”

Section: Imagingmentioning

confidence: 99%

Cystic Neoplasms of the Liver: Biliary Cystadenoma and Cystadenocarcinoma

Soares

Arnaoutakis

Kamel

et al. 2014

Journal of the American College of Surgeons

156

138

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“…[9] CA19-9 may not contribute to the differential diagnosis of congenital hepatic cysts with intracystic hemorrhage. [10] Choi et al [11] showed that CA19-9 and carcinoembryonic antigen levels in the cystic fluid were of little significance for differentiating between biliary cystadenoma and a simple hepatic cyst. Bertino et al [12,13] showed that serum CA19-9 levels were frequently elevated in chronic viral hepatitis and hepatic cirrhosis.…”

Section: Discussionmentioning

confidence: 99%

Congenital hepatic cyst with intracystic hemorrhage

Zhang

Yang

et al. 2016

Medicine

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Introduction:Fast-growing congenital hepatic cysts with intracystic hemorrhage are rare in clinical practice. Additionally, the clinical manifestations of and laboratory and imaging findings for this condition are often nonspecific and are particularly difficult to differentiate from those of hepatobiliary cystadenoma and cystadenocarcinoma, thus posing great challenges for diagnosis and treatment. The 2 case reports presented here aim to analyze the diagnosis and treatment of 2 rare cases of congenital hepatic cysts with intracystic hemorrhage in the Chinese Han population to provide an important reference for the clinical diagnosis and treatment of this condition.Diagnoses:These 2 case reports present 2 rare cases of congenital hepatic cysts with intracystic hemorrhage. Case 1 involved a 31-year-old patient with a very large, fast-growing hepatic cyst with intracystic hemorrhage and elevated carbohydrate antigen 199. Case 2 involved a patient with intense, paroxysmal right upper abdominal pain; computed tomography suggested a hepatic cyst with intracystic hemorrhage and possibly hepatobiliary cystadenoma.Outcomes:Both patients underwent liver resection. Postoperative follow-up showed that for both patients, the symptoms improved, the laboratory findings returned to normal levels, and the surgical outcomes were satisfactory.Conclusion:Liver resection is an ideal treatment for patients with congenital hepatic cysts with intracystic hemorrhage, and especially those with fast-growing, symptomatic hepatic cysts or hepatic cysts that are difficult to differentiate from hepatobiliary cystadenoma and cystadenocarcinoma.

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Differential Diagnosis for Intrahepatic Biliary Cystadenoma and Hepatic Simple Cyst

Abstract: Cystic fluid carbohydrate antigen 19-9 levels and carcinoembryonic antigen levels were not useful for differential diagnosis of BCA vs. HSC. BCA were more common than HSCs in females, patients with a septum, and patients with septal thickening.

Cited by 90 publications

References 10 publications

Biliary Cystadenomas: A Case for Complete Resection

Biliary Cystadenomas: A Case for Complete Resection

Cystic Neoplasms of the Liver: Biliary Cystadenoma and Cystadenocarcinoma

Congenital hepatic cyst with intracystic hemorrhage

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