Differential diagnosis of eccrine spiradenoma: A case report

Abstract

Eccrine spiradenoma (ES) is a rare, benign adnexal neoplasm that may easily be mistaken for glomus lesions or angioleiomyoma due to its painfulness and florid vascularization. A 44-year-old male with a blue-colored, nodular tumor on the left knee, present for 10 years, was submitted for diagnosis. Dermatological examination was undertaken, followed by surgical excision of the subcutaneous lesion and histopathological examination of the tissue. Subjective symptoms included tenderness upon palpation and routine investigations were within normal limits. Immunohistochemical analysis of the tumor cells demonstrated positive staining for CK5/CK6, CK8/CK18, S100, as well as small vacuole-like positive for EMA, and was therefore diagnosed as ES. The results of the present study suggest that immunohistochemical assays may be helpful to clarify the diagnosis and differentiate ES from other painful subcutaneous tumors exhibiting similar clinical and histological presentations.

Heterozygous cylindromatosis gene mutation c.1628_1629delCT in a family with brook-spiegler syndrome

“…On the other hand, there have been described some cases of multiple familial spiradenomas, predominantly located in the scalp. [ 8 9 10 ] No genetic study was performed in these cases; therefore, it could not be confirmed the existence of BRSS or one phenotypic variation.…”

“…[ 1 4 ] BSS has also been associated with increased risk of salivary glands neoplasms and other tumors although with very little evidence. [ 1 8 9 ]…”

“…[ 5 ] Malignant spiradenoma is a very aggressive neoplasm with a risk of metastasis around 50% and a mortality of 39% if left untreated. [ 8 9 ]…”

A rare case of Brooke-Spiegler syndrome: integrated surgical treatment of multiple giant eccrine spiradenomas of the head and neck in a young girl

“…The presence of concomitant cylindroma, trichoepithelioma, and spiradenoma should promptly suspect a diagnosis of Brooke–Spiegler Syndrome (BSS) [ 2 , 4 ]. BSS is a rare autosomal dominant disorder characterized by a predisposition for the development of multiple adnexal neoplasms.…”

“…Malignant ES, or spiradenocarcinoma, is exceedingly rare but quite aggressive. It generally arises from long-standing benign ES [ 4 , 7 , 8 ]. Dabska et al [ 9 ] first described spiradenocarcinoma in 1972 and only ∼150 cases of malignant transformation are reported in the literature [ 10 ].…”