Differential diagnosis of osteoblastic metastases from bone islands in patients with lung cancer by single-source dual-energy CT: Advantages of spectral CT imaging

Dong, Yue; Zheng, Shusen; Machida, Haruhiko; Wang, Bing; Liu, Ailian; Liu, Yijun; Zhang, Xin

doi:10.1016/j.ejrad.2015.01.007

Cited by 62 publications

(31 citation statements)

References 27 publications

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“…The use of a three-material decomposition model allows for the creation of VNCa images by subtracting calcium from CT data. To date, few studies have reported on the use of this technique to directly depict (a) trauma-associated bone marrow edema in the extremities (9,10) or spine (11)(12)(13)(14)22,23) or (b) malignant bone marrow infiltration (15,16,24). However, to our knowledge, this is the first and largest prospective study to address the bone marrow edema associated with inflammatory rheumatic disorders when using dual-energy CT (25,26).…”

Section: Quantitative Analysis Of Bone Marrow Ct Numbersmentioning

confidence: 99%

Axial Spondyloarthritis: Dual-Energy Virtual Noncalcium CT in the Detection of Bone Marrow Edema in the Sacroiliac Joints

Zhang

Shi

et al. 2019

Radiology

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I n the management of symptomatic axial spondyloarthritis (axSpA), it is important to accurately monitor current disease activity and the extent of structural damage (1). Recent European League Against Rheumatism recommendations on the use of MRI in patients with axSpA show that this imaging modality should be considered for use in the detection of both subchondral bone marrow edema and structural lesions (2-4). Although MRI is especially capable of directly depicting bone marrow edema not detected with other imaging modalities, it is more time consuming and expensive than would be reasonable for routine use (5-7). Although conventional CT is generally regarded as a more reliable method with which to detect structural sacroiliac joint lesions, such as minute erosions, and although it is relatively affordable, highly available, and requires shorter examination times than MRI, it is not widely used because it cannot be used to assess bone marrow edema (2,8). Dual-energy CT is an imaging technique that enables detection of traumatic bone marrow edema (9-14) and plasma cell infiltration of bone marrow (15,16) with high sensitivity and specificity if the patients were examined with a dual-energy mode. Dual-energy CT acquires two CT data sets at different energy levels simultaneously, and it can subsequently quantify and remove the individual chemical elements, like calcium, from those data sets. Postprocessing software is then used to remove calcium in trabecular bone by using the virtual noncalcium subtraction process, thus creating virtual noncalcium (VNCa) images (9-12). Increased water content (edema) or cellular components (multiple myeloma or bone metastases) in the bone marrow can be seen on VNCa images. We hypothesized that dual-energy CT with visual analysis of color-coded images and quantitative regionof-interest (ROI)-based density measurements could enable detection of sacroiliac joint bone marrow edema in participants with axSpA, with precision comparable to that of MRI. Thus, the purpose of our study was to determine the diagnostic performance of a dual-energy CT VNCa technique in the detection and depiction of the

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Section: Quantitative Analysis Of Bone Marrow Ct Numbersmentioning

confidence: 99%

Axial Spondyloarthritis: Dual-Energy Virtual Noncalcium CT in the Detection of Bone Marrow Edema in the Sacroiliac Joints

Zhang

Shi

et al. 2019

Radiology

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“…75,76 Dual-energy CT was already demonstrated to be a useful tool in different musculoskeletal settings to better evaluate tissue composition than standard CT, besides allowing the identification of bone marrow edema and reducing metal artifacts. 77 This technique already showed initial interesting results in the differentiation of bone malignancies from benign lesions, [78][79][80] as well as to define neoplastic marrow infiltration, 81,82 but far too little has been written on this topic to clearly state the actual role of dual-energy CT in the imaging of bone tumors. Lastly, a potential line of research in bone tumors is probably the application of texture analysis and artificial intelligence, the subject of several studies in different oncologic fields, but, to date, there is still no published article on SBTs.…”

Section: New Perspectivesmentioning

confidence: 99%

Differential Diagnosis of Spine Tumors: My Favorite Mistake

Albano

Messina

Gitto

et al. 2019

Semin Musculoskelet Radiol

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Imaging has a pivotal role in the detection and characterization of spine bone tumors (SBTs), especially using magnetic resonance (MR) imaging and computed tomography (CT). Although MR performed with conventional pulse sequences has a robust reliability in the assessment of SBTs, some imaging features of benign lesions and malignancies overlap, making the differential diagnosis challenging. Several imaging tools are now available to perform a correct interpretation of images of SBTs including diffusion-weighted imaging, dynamic contrast-enhanced MR, Dixon sequences, and dual-energy CT. Nevertheless, strengths and weaknesses of imaging modalities should be kept in mind, and it is crucial to be aware of the pitfalls that can be encountered in daily clinical practice when dealing with these lesions. This review provides an overview on the main challenges encountered when dealing with SBTs, providing some tricks of the trade to avoid possible diagnostic traps.

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“…Quantitative material analysis of a lesion and evaluation of spectral energy curves with DECT were used to differentiate lytic metastases from Schmorl's nodes 74 and osteoblastic metastases from bone islands. 75…”

Section: Quantitative Tissue Decomposition In the Evaluation Of Bone mentioning

confidence: 99%

Musculoskeletal Imaging: Current Practice and Future Directions

Farrell

Adams

Walsh

et al. 2018

Semin Musculoskelet Radiol

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Musculoskeletal (MSK) radiology plays a crucial role in the diagnosis and management of MSK disorders and has rapidly expanded in tandem with advances in technology and improved access to imaging. Although anatomical imaging remains the mainstay of MSK radiology, significant progress has been made in functional and molecular imaging as well as in hybrid imaging with an expanding armament of technologies becoming available or in development. A vast array of research is occurring in MSK imaging, and this review article highlights some of the most promising current and future clinical applications in development in each of the major imaging modalities. Identifying the clinical utility of these technologies in an era of rising health care costs is an important challenge for MSK radiologists.

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Differential diagnosis of osteoblastic metastases from bone islands in patients with lung cancer by single-source dual-energy CT: Advantages of spectral CT imaging

Cited by 62 publications

References 27 publications

Axial Spondyloarthritis: Dual-Energy Virtual Noncalcium CT in the Detection of Bone Marrow Edema in the Sacroiliac Joints

Axial Spondyloarthritis: Dual-Energy Virtual Noncalcium CT in the Detection of Bone Marrow Edema in the Sacroiliac Joints

Differential Diagnosis of Spine Tumors: My Favorite Mistake

Musculoskeletal Imaging: Current Practice and Future Directions

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