Differential diagnostic performance of acoustic radiation force impulse imaging in small (≤20 mm) breast cancers: Is it valuable?

Wang, Sida; Wang, Lei; Li, Zhixian; Wei, Kang-Lai; Liao, Xin-Hong; Chen, Yuanyuan; Huang, Xue

doi:10.1038/s41598-017-08004-y

Cited by 6 publications

(4 citation statements)

References 24 publications

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“…The falsenegative rate of r-US in combination with mammography (9.7%) was higher than what we found for r-US alone (5.6%). Although the false-negative rates for m-US vary in the literature (3.6-7.5%) [20,25,26], we found the same value for r-US and m-US (5.6%). Two lesions were wrongly classified as BI-RADS 3 lesions by m-US and r-US, while histology revealed a DCIS and an invasive ductal triple negative breast cancer.…”

Section: Discussionsupporting

confidence: 57%

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Comparison of radial and meander-like breast ultrasound with respect to diagnostic accuracy and examination time

Jäggi-Wickes

Brasier-Lutz

Schaedelin

et al. 2020

Arch Gynecol Obstet

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Purpose To prospectively compare the diagnostic accuracy of radial breast ultrasound (r-US) to that of conventional meander-like breast ultrasound (m-US), patients of a consecutive, unselected, mixed collective were examined by both scanning methods. Methods Out of 1948 dual examinations, 150 revealed suspicious lesions resulting in 168 biopsies taken from 148 patients. Histology confirmed breast cancers in 36 cases. Sensitivity, specificity, accuracy, PPV, and NPV were calculated for r-US and m-US. The examination times were recorded. Results For m-US and r-US, sensitivity (both 88.9%), specificity (86.4% versus 89.4%), accuracy (86.9% versus 89.3%), PPV (64.0% versus 69.6%), NPV (both 98.3%), false-negative rate (both 5.6%), and rate of cancer missed by one method (both 5.6%) were similar. The mean examination time for r-US (14.8 min) was significantly (p < 0.01) shorter than for m-US (22.6 min). Conclusion Because the diagnostic accuracy of r-US and m-US are comparable, r-US can be considered an alternative to m-US in routine breast US with the added benefit of a significantly shorter examination time.

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Section: Discussionsupporting

confidence: 57%

“…The diagnostic accuracy of r-US was 89.3% which corresponds to the highest values found for m-US [19,20]. Similarly, PPV (69.6%) and NPV (98.3%) for r-US were in the range compared to published m-US data [20,21,[23][24][25].…”

Section: Discussionmentioning

confidence: 73%

Comparison of radial and meander-like breast ultrasound with respect to diagnostic accuracy and examination time

Jäggi-Wickes

Brasier-Lutz

Schaedelin

et al. 2020

Arch Gynecol Obstet

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“…The first excitation method involves applied manual compression, where the operator can exert pressure on the tissue with the ultrasound transducer to image superficial organs. The other excitation method requires the transducer to be held stationary while the internal physiological mechanisms (e.g., cardiovascular movement, respiration) induce the tissue deformation that is measured ( 42 ). This method is better suited to assess deeper internal organs as it is not dependent on the applied pressure of the operator.…”

Section: Ultrasound For Elasticity Imagingmentioning

confidence: 99%

Visualizing tactile feedback: an overview of current technologies with a focus on ultrasound elastography

Kumar,

Kempski Leadingham,

Kerensky

et al. 2023

Front. Med. Technol.

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Tissue elasticity remains an essential biomarker of health and is indicative of irregularities such as tumors or infection. The timely detection of such abnormalities is crucial for the prevention of disease progression and complications that arise from late-stage illnesses. However, at both the bedside and the operating table, there is a distinct lack of tactile feedback for deep-seated tissue. As surgical techniques advance toward remote or minimally invasive options to reduce infection risk and hasten healing time, surgeons lose the ability to manually palpate tissue. Furthermore, palpation of deep structures results in decreased accuracy, with the additional barrier of needing years of experience for adequate confidence of diagnoses. This review delves into the current modalities used to fulfill the clinical need of quantifying physical touch. It covers research efforts involving tactile sensing for remote or minimally invasive surgeries, as well as the potential of ultrasound elastography to further this field with non-invasive real-time imaging of the organ’s biomechanical properties. Elastography monitors tissue response to acoustic or mechanical energy and reconstructs an image representative of the elastic profile in the region of interest. This intuitive visualization of tissue elasticity surpasses the tactile information provided by sensors currently used to augment or supplement manual palpation. Focusing on common ultrasound elastography modalities, we evaluate various sensing mechanisms used for measuring tactile information and describe their emerging use in clinical settings where palpation is insufficient or restricted. With the ongoing advancements in ultrasound technology, particularly the emergence of micromachined ultrasound transducers, these devices hold great potential in facilitating early detection of tissue abnormalities and providing an objective measure of patient health.

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“…Despite the advances in diagnostics and treatments, 20%–30% of patients with primary breast cancer experience recurrence and distant metastasis ( Duma, 2018 ). Furthermore, advanced breast cancer has a poor prognosis ( Wang et al, 2017 ). Although research on breast cancer pathogenesis has made great strides, including the tumor microenvironment (TME) and energy metabolism, the underlying pathogenesis of breast cancer must be clarified ( Zhou et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

ATP6AP1 is a potential prognostic biomarker and is associated with iron metabolism in breast cancer

et al. 2022

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Cancer occurrence and progression may be facilitated by aberrant expression of ATPase H+ transporting accessory protein 1 (ATP6AP1). However, the clinical relevance of ATP6AP1 in breast cancer remains unclear. In this study, we investigated the association between ATP6AP1 and breast cancer. Data collected from patients with breast cancer from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) were used in this study. To determine the relationship between ATP6AP1 and breast cancer survival rates, Kaplan-Meier analysis was used. To determine the prognostic value of ATP6AP1, a receiver operating characteristic (ROC) curve was constructed. To identify the major pathways involving ATP6AP1, we performed functional enrichment analysis using gene set enrichment analysis (GSEA). We analyzed the association between ATP6AP1 expression and tumor immunity using the ESTIMATE algorithm and single-sample GSEA (ssGSEA). A nomogram based on a Cox regression analysis was constructed to predict the impact of ATP6AP1 on prognosis. ATP6AP1 expression was significantly upregulated in breast cancer tissues. Moreover, patients with elevated ATP6AP1 expression had shorter total survival rates than those with lower expression levels (p = 0.032). The area under the receiver operating characteristic curve for ATP6AP1 was 0.939. Gene set enrichment analysis revealed that reaction iron uptake and transport, proteasome degradation, glutathione metabolism, and pyruvate metabolism were enriched in the ATP6AP1 high expression phenotype. The relationship between immune infiltration cells and ATP6AP1 expression, including macrophages, B cells, dendritic cells, cytotoxic cells, NK cells, and T cells, was found to be negative, suggesting that ATP6AP1 overexpression results in immunosuppression. Based on the Cox regression analyses, the calibration plot of the nomogram demonstrated effective performance in predicting breast cancer patients. ATP6AP1 may facilitate breast cancer progression by inhibiting antitumor immunity and promoting iron metabolism and may be a biomarker for breast cancer prognosis.

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Differential diagnostic performance of acoustic radiation force impulse imaging in small (≤20 mm) breast cancers: Is it valuable?

Cited by 6 publications

References 24 publications

Comparison of radial and meander-like breast ultrasound with respect to diagnostic accuracy and examination time

Comparison of radial and meander-like breast ultrasound with respect to diagnostic accuracy and examination time

Visualizing tactile feedback: an overview of current technologies with a focus on ultrasound elastography

ATP6AP1 is a potential prognostic biomarker and is associated with iron metabolism in breast cancer

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