Differential distribution of γδT-cell receptor lymphocyte subpopulations in blood and spleen of young and adult cattle

Wyatt, Carol R.; Madruga, C. R.; Cluff, Chris; Parish, S. M.; Hamilton, Mary Jo; Goff, Will L.; Davis, William C.

doi:10.1016/0165-2427(94)90019-1

Cited by 97 publications

(56 citation statements)

References 22 publications

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“…The distribution of cells represented by this collection of surface markers is similar to that observed in young calves (Ͻ6 months) with the TCR-1 ϩ population predominating in the peripheral circulation (Fig. 1) [13].…”

Section: Assessment Of Reconstitution In Scid-bo Micesupporting

confidence: 51%

“…The WC-1 molecule is a member of the cysteine-rich scavenger receptor superfamily (CRSR) of molecules and serves as a marker for the predominant population of ␥/␦ T cells in the peripheral circulation of calves up to 1 year of age [12][13][14]. ␥/␦ T cells have been shown to respond to mycobacterial heat shock proteins as well as to recognize non-peptide mycobacterial antigens in the context of CD1, an activity also shared by CD8 ϩ T cells [15,16].…”

Section: Introductionmentioning

confidence: 99%

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Role of CD8+ and WC-1+ γ/δ T cells in resistance to Mycobacterium bovis infection in the SCID-bo mouse

Smith

Kreeger

Alvarez

et al. 1999

Journal of Leukocyte Biology

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The role of various effector T cell populations in the bovine immune response toMycobacterium bovis infection is poorly understood. This is largely due to the difficulties associated with performing in vivo challenge studies in the natural host species. In this report, we utilized a fetal bovine-severe combined immunodeficient (SCID-bo) xenochimeric mouse model to study the protective role of two putative effector cell types, CD8 ؉ T cells and a subpopulation of ␥/␦ T cells that express WC-1, a member of the cysteine-rich scavenger receptor superfamily (CRSR). We demonstrate that CD8 ؉ T cells play a key role in protection and contribute substantially to bovine IFN-␥ mRNA levels at 30 days post-infection. The role of WC-1 bearing cells to protection was less definitive but our results suggest that this population may play a pivotal role early in infection. Granuloma architecture was altered in anti-WC-1 (ILA29) but not anti-CD8 (ILA51) -treated animals, suggesting that this population may be involved in recruitment of various cell types to sites of infection. J. Leukoc. Biol. 65: 28-34; 1999.

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Section: Assessment Of Reconstitution In Scid-bo Micesupporting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Role of CD8+ and WC-1+ γ/δ T cells in resistance to Mycobacterium bovis infection in the SCID-bo mouse

Smith

Kreeger

Alvarez

et al. 1999

Journal of Leukocyte Biology

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“…Phenotypic analysis of elk PBMC revealed similar percents of lymphocyte subsets as described previously for red deer (Buchan and Griffin, 1990;Cross et al, 1996a) and other domestic ruminant species (Smith et al, 1994;Wyatt et al, 1994). An unusual finding of the present study was the differential expression of the scavenger receptor, WC1, by ␥␦ TCR ϩ cells (e.g., WC1 hi , WC1 lo , and WC1 Ϫ ).…”

Section: Discussionmentioning

confidence: 77%

“…Approximately one third of ␥␦ TCR ϩ cells were WC1 Ϫ . In cattle, it was estimated that approximately 90% of peripheral blood ␥␦ TCR ϩ cells co-express WC1 (Park et al, 1993;Wyatt et al, 1994). The majority of cells proliferating in non-stimulated cultures were ␥␦ TCR ϩ cells.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Mitogen-Stimulated Lymphocyte Subset Proliferation and Nitric Oxide Production by Peripheral Blood Mononuclear Cells of Captive Elk (Cervus Elaphus)

Waters

Sacco

Fach

et al. 2002

Journal of Wildlife Diseases

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“…γδ T cells represent 10 -20 % of circulating T cells in adult cattle, but up to 55 % in newborn calves compared to just 1 -10 % in adult humans [30]. They can be classified according to expression of WC1 receptor, with the principal bovine γδ T cells in the circulation being WC1 + CD2 -CD4 -CD8 -.…”

Section: Immunity Against M Bovis Infection In Cattlementioning

confidence: 99%

Immunity and Vaccination against Tuberculosis in Cattle

Parlane¹,

Buddle²

2015

Curr Clin Micro Rpt

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Bovine tuberculosis (TB) continues to be a major animal health problem worldwide and new tools are required for the control of this disease in cattle, particularly with the emergence of wildlife reservoirs for Mycobacterium bovis infection and potential restrictions on trade. New insights into the roles of macrophages, dendritic cells, NK cells, and CD4+, CD8+, and γδ T cells in control of M. bovis infection in cattle have provided a better understanding of protective immunity against this disease. In the past two decades, considerable progress has been made in the development and evaluation of TB vaccines for cattle, with new attenuated mycobacterial vaccines providing an alternative to the use of BCG vaccine and sub-unit vaccines to boost protection induced by BCG. With the development of tests to differentiate infected from vaccinated animals, it is now feasible to use vaccines to assist in the control of this disease.

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Differential distribution of γδT-cell receptor lymphocyte subpopulations in blood and spleen of young and adult cattle

Cited by 97 publications

References 22 publications

Role of CD8+ and WC-1+ γ/δ T cells in resistance to Mycobacterium bovis infection in the SCID-bo mouse

Role of CD8+ and WC-1+ γ/δ T cells in resistance to Mycobacterium bovis infection in the SCID-bo mouse

Analysis of Mitogen-Stimulated Lymphocyte Subset Proliferation and Nitric Oxide Production by Peripheral Blood Mononuclear Cells of Captive Elk (Cervus Elaphus)

Immunity and Vaccination against Tuberculosis in Cattle

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