Differential effect of a dietary soybean phosphatidylcholine and phospholipid mixture on hematologic parameters, and serum lipids in rats.

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

Hoshi

Tsutsumi

et al. 1991

The effect of safflower phospholipid (SP) on plasma and liver lipids in rats fed a hypercholesterolemic diet was examined. Tri glyceride mixture (SPO) of safflower oil and palm oil (8:2) containing almost comparable amounts of linoleic acid to safflower phospholipid was used as a control diet. Similarly, the effect of paste safflower phospholipid (PSP) which contains approximately 45% of neutral lipid was also compared to safflower oil (SO). Concentrations of total cholesterol in plasma and liver of rats fed the SP diet were markedly decreased in comparison with those of the other diets, but a slight reduction of total cholesterol in plasma and liver was observed in rats fed PSP diet. SP and PSP induced a reduction in the plasma level of low density lipoprotein (LDL) cholesterol as well as an increase in the level of high density lipoprotein (HDL) cholesterol. The activity of plasma lecithin cholesterol acyltransferase (LCAT) was greatly increased in rats fed SP diet. These results suggest that the safflower phospholipids suppress the elevation of plasma and liver cholesterol and that this effect may depend on the phospholipid content in dietary lipid. Key Words safflower phospholipid, lipoproteins, plasma cholesterol, liver cholesterol, lecithin-cholesterol acyltransferase, rats Recently there are many studies on the hypocholesterolemic effects of dietary AND PLASMA LIPOPROTEINS 593

Section: Discussionsupporting

confidence: 91%

mentioning

confidence: 99%

Effect of Dietary Safflower Phospholipid on Plasma and Liver Lipids in Rats Fed a Hypercholesterolemic Diet.

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

Hoshi

Tsutsumi

et al. 1991

“…This result was similar to those of the previous experiments in rats [5][6][7]9, 10] and humans [1]. Although both safflower phospholipid and soybean phospholipid decreased the liver cholesterol in rats fed a hypercholesterolemic diet [ 11 ] , safflower phospholipid only decreased the liver cholesterol in rats fed a cholesterol-free diet.…”

Section: Discussionsupporting

confidence: 81%

“…These results suggest that, in addition to soybean phospholipid, safflower phospholipid decreases plasma and liver cholesterol in rats fed a cholesterol-free diet and safflower phospholipid causes a favorable alteration in plasma and liver lipids compared with soybean phospholipid. The effect of dietary phospholipids on serum lipids and lipoproteins has been extensively studied in humans [1 -3 ] and rats [4][5][6][7][8][9]. However, the mechanisms of cholesterol-lowering action of dietary phospholipids have still not been clarified.…”

Section: Discussionmentioning

confidence: 99%

Effect of Dietary Safflower Phospholipid and Soybean Phospholipid on Plasma and Liver Lipids in Rats Fed a Cholesterol-Free Diet.

J. Clin. Biochem. Nutr.

Takehisa

Tsutsumi

et al. 1992

SummaryThe effect of dietary safflower phospholipid (Saf-PL) and soybean phospholipid (Soy-PL) on plasma, lipid, and fecal lipids in rats fed a cholesterol-free diet was compared with that of a triglyceride mixture (control). The triglyceride mixture (SP-Oil) of safflower oil and palm oil (8 : 2) contained almost comparable amounts of linoleic acid to safflower phospholipid or soybean phospholipid. Concentrations of total cholesterol in plasma of rats fed the Saf-PL and Soy-PL diets were significantly decreased in comparison with that of the SP-Oil diet. Saf-PL induced a reduction in the concentration of liver cholesterol compared with SP-oil. Soy-PL tended to reduce the liver cholesterol. The proportions of total cholesterol in all lipoprotein fractions were similar among the groups. The activity of plasma lecithin-cholesterol acyltransferase was increased in rats fed the phospholipid diets; Saf-PL indicated the highest value. Saf-PL and Soy-PL caused an enhanced excretion of not only neutral steroids but also acidic steroids into feces compared with SP-oil. These results suggest that, in addition to soybean phospholipid, safflower phospholipid decreases plasma and liver cholesterol in rats fed a cholesterol-free diet and safflower phospholipid causes a favorable alteration in plasma and liver lipids compared with soybean phospholipid.

“…The effect of dietary phospholipids on serum lipids and lipoproteins has been extensively studied in humans (1)(2)(3) and rats (4)(5)(6)(7)(8)(9). However, the mechanisms of cholesterol-lowering action of dietary phospholipids have still not been clarified .…”

mentioning

confidence: 99%

The Effect of Dietary Safflower Phospholipid and Soybean Phospholipid on Plasma and Liver Lipids in Rats Fed a Hypercholesterolemic Diet.

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

Hoshi

Takehisa

et al. 1992

SummaryThe effect of dietary safflower phospholipid (Saf-PL) and soybean phospholipid (Soy-PL) on plasma, liver, and fecal lipids in rats fed a hypercholesterolemic diet was compared with that of triglyceride mixture (controls). Triglyceride mixture (SP-Oil) of safflower oil and palm oil (8:2) contained almost comparable amounts of linoleic acid to safflower phospholipid or soybean phospholipid. Concentration of total cholesterol in plasma of rats fed the Saf PL and Soy-PL diets were significantly decreased in comparison with that of the SP-Oil diet. Simi larly, both Saf PL and Soy-PL induced a reduction in the concentration of liver cholesterol compared with SP-Oil; Saf PL indicated the lowest value. Saf PL only significantly increased the level of high density lipoprotein (HDL) cholesterol. The level of chylomicron plus very low density lipoprotein (VLDL) cholesterol was lower in rats fed the Saf-PL and Soy-PL diets than that of the SP-Oil diet. The activity of plasma lecithin-cholesterol acyltransferase (LCAT) was increased in rats fed Saf-PL and Soy-PL. Saf PL and Soy-PL caused an enhanced excretion of fecal neutral steroids, but not acidic steroids compared with SP-Oil. These results suggest that, in addition to soybean phospholipid, safflower phospholipid suppresses the elevation of plasma and liver cholesterol and that this effect may be brought about by inhibiting the absorption of cholesterol in the small intestine.