Differential effect of CCl4 on renal function in cirrhotic and non-cirrhotic rats

Functional Assessments and Histopathology of Hepatorenal Tissues of Wistar Rats Infused with Carbon Tetrachloride and Treated with Raw and Hydrothermal Processed Herbs

“…The present findings confirmed previous research outcomes, which noted that acute chemical intoxication that caused morphological and functional damages to hepatic tissues predisposed animal models to developing acute renal dysfunction. 1,5,6,8,9 Fibrotic rats treated with raw and hydrothermal processed herbs showed evidence of limited amelioration of impaired renal function, typified by their lowered serum creatinine and urea concentrations compared to that of Group 3. In a related study, Elgazar and AboRaya, 103 using serum urea and creatinine concentrations as biomarkers, noted that single and combinatorial formulations of Petroselinum sativum, Eruca sativa and Curcuma longa ameliorated gentamicin-induced renal tubular necrosis in adult male Sprague Dawley rats.…”

“…Generally, serum TC, TAG and LDL-C concentrations of Groups (5-12) were higher than that of Group 4, and in turn, those of Group 4 was higher than those of Group 1 and Group 2; p < 0.05. An overview of Table 2 showed that atherogenic indices of Group 1 and Group 2 were below the critical values, whereas those of Groups (3)(4)(5)(6)(7)(8)(9)(10)(11)(12) were within the following ranges: TAG/HDL-C ratio (3.59 ± 0.03 -6.76 ± 0.06), TC/HDL-C ratio (3.72 ± 0.02 -6.94 ± 0.05) and LDL-C/HDL-C ratio (2.00 ± 0.01 -4.59 ± 0.02). The histopathological features of hepatic tissue sections of the experimental rat groups are presented in Figure 6.…”

“…4 Biochemical investigations using hepatic and renal functional indices, the so-called liver function test (LFT) and kidney function test (KFT), coupled with histopathological studies have revealed that dysfunctional and morphological damage hepatic tissues predispose animal models to developing acute renal failure when exposed, in acute way, to chemical toxicants. 5,6,7,8,9 Carbon tetrachloride (CCl 4 ) is a chemical agent noted to be toxic to hepatorenal tissues in experimental animals and human subjects. 5,6,8,10,11,12,13 Reports showed that CCl 4 toxicity is elicited by microsomal CYP2E1-induced formation of reactive trichloromethyl (CCl 3…”

“…5,6,7,8,9 Carbon tetrachloride (CCl 4 ) is a chemical agent noted to be toxic to hepatorenal tissues in experimental animals and human subjects. 5,6,8,10,11,12,13 Reports showed that CCl 4 toxicity is elicited by microsomal CYP2E1-induced formation of reactive trichloromethyl (CCl 3…”

“…Studies have shown that CCl 4 infusion or inhalation elicits chemical-induced multiple organ lesions such as fibrosis, cirrhosis and hepatocarcinoma, 12,13,35,36 and by extension, renal dysfunction in animal models. 5,6,12 Organ lesion and ensuing pathology elicit wide variations in concentrations of metabolites and elevation of non-functional plasma enzymes in blood samples of experimental animals. Specifically, because plasma lipoproteins, for the most part, are biosynthesized in the hepatocytes, chemical and biotic agents that impact negatively on liver functional integrity distort plasma lipid patterns.…”