Reduction of carbon tetrachloride‐induced nephropathy by melatonin administration

Ögetürk, Murat; Kuş, İlter; Kavakli, Ahmet; Öner, Jale; Kükner, Aysel; Sarsılmaz, Mustafa

doi:10.1002/cbf.1166

Cited by 31 publications

(26 citation statements)

References 42 publications

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“…In addition, in animals treated with LPS, melatonin abolished the increment in lipid peroxidation and managed to offset the hepatic degenerative changes. In experiments in vivo, the administration of melatonin prevented carbon tetrachloride (CCl 4 ) induced lipid peroxidation in the kidney and liver 35 . There are many characteristics which melatonin possesses which aids its ability to inhibit lipid peroxidation: (a) it is 38 which propagate peroxidation, as well as the highly reactive singlet oxygen 39 .…”

Section: Discussionmentioning

confidence: 99%

Melatonin attenuates methotrexate‐induced oxidative stress and renal damage in rats

Abraham

Kolli

Rabi³

2010

Cell Biochemistry & Function

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Nephrotoxicity is an adverse side effect of methotrexate (MTX) chemotherapy. The present study verifies whether melatonin, an endogenous antioxidant prevents MTX-induced renal damage. Adult rats were administered 7 mg/kg body weight MTX intraperitoneally for 3 days. In the melatonin pretreated rats, 40 mg/ kg body weight melatonin was administered daily intraperitoneally 1 h before the administration of MTX. The rats were killed 12 h after the final dose of MTX/vehicle. The kidneys were used for light microscopic and biochemical studies. The markers of oxidative stress were measured along with the activities of the antioxidant enzymes and myeloperoxidase activity in the kidney homogenates. Pretreatment with melatonin reduced MTX induced renal damage both histologically and biochemically as revealed by normal plasma creatinine levels. Melatonin pretreatment reduced MTX induced oxidative stress, alteration in the activity of antioxidant enzymes as well as elevation in myeloperoxidase activity. The results suggest that melatonin has the potential to reduce MTX induced oxidative stress, neutrophil infiltration as well as renal damage. As melatonin is an endogenous antioxidant and is non-toxic even in high doses it is suggested that melatonin may be beneficial in minimizing MTX induced renal damage in humans.

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Section: Discussionmentioning

confidence: 99%

Melatonin attenuates methotrexate‐induced oxidative stress and renal damage in rats

Abraham

Kolli

Rabi³

2010

Cell Biochemistry & Function

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“…a hydroxyl radical and a peroxyl radical scavenger. 29,30 It has also been shown that when animals and tissues are subjected to lipid peroxidation, melatonin causes a substantial protection against the oxidative destruction of lipids. 31 However, to our knowledge, there is no experimental study concerning the protective effects of melatonin against neuronal damage in prefrontal cortex induced by HCHO.…”

Section: Introductionmentioning

confidence: 99%

Melatonin prevents formaldehyde‐induced neurotoxicity in prefrontal cortex of rats: an immunohistochemical and biochemical study

Zararsız

Kuş

Ögetürk

et al. 2006

Cell Biochemistry & Function

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This study was undertaken to investigate the protective effects of melatonin against formaldehyde-induced neurotoxicity in prefrontal cortex of rats. For this purpose, 21 male Wistar rats were divided into three groups. The rats in Group I were used as a control, while the rats in Group II were injected every other day with formaldehyde. The rats in Group III received melatonin daily while exposed to formaldehyde. At the end of 14-day experimental period, all rats were killed by decapitation. The brains of the rats were removed and the prefrontal cortex tissues were obtained from all brain specimens. Some of the prefrontal cortex tissue specimens were used for determination of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) levels. The remaining prefrontal cortex tissue specimens were used for immunohistochemical evaluation. The levels of SOD and GSH-Px were significantly decreased, and MDA levels, were significantly increased in rats treated with formaldehyde compared with those of the controls. In the immunohistochemical evaluation of this group, apoptotic cells were observed. However, increased SOD and GSH-Px enzyme activities, and decreased MDA levels, were detected in the rats administered melatonin while exposed to formaldehyde. Furthermore, apoptotic changes caused by formaldehyde were decreased in these rats. The results of our study suggest that melatonin treatment prevents formaldehyde-induced neuronal damage in prefrontal cortex.

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“…In certain studies (6,16), an antioxidant effect was obtained when 10 mg/kg MLT was administered; as this dosage was the dose we used, however in some studies (18), it was reported that, antioxidant effect was obtained only when a dose of 25 mg/kg was administered. In the present study, both in the liver and kidney tissues, Vitamin C group MDA values were found quite close to the MDA values of the control group when compared with other groups.…”

Section: Discussionmentioning

confidence: 98%

“…However the pathology related with renal function failure that is stimulated by CCl 4 remains controversial. As kidneys have an affinity against CCl 4 , and as they contain predominantly, cystochrome p450 in the cortex, it is very possible that CCl 4 contributes a lot to nephrotoxicity (18). Even though Rincon et al (19) demonstrated that the effects of CCl4 on the structure and function of kidneys are dependant to the functional state of the liver.…”

Section: Discussionmentioning

confidence: 99%

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Protective Effects of Antioxidants on the Experimental Liver and Kidney Toxicity in Mice

et al. 2008

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and Pathology 3 , Van, Turkey.Aim: Liver and kidney are exposed to a lot of oxidant substances that are both from exogen and endogen sources. The aim of this study was to investigate the antioxidant effects of C vitamine, Melatonine (MLT) and N-acetylcystein (NAC) in carbon tetrachlorur (CCl 4 ) induced oxidative stress in mouse.Methods: The study involved 6 groups; control group (Group 1), CCl 4 group (Group 2), CCl 4 + C vitamine group (Group 3), CCl 4 + MLT group (Group 4), CCl 4 + NAC group (Group 5) and combined (CCl 4 + C vitamine + MLT + NAC) group (Group 6) with each group containing 10 mice. Starting from the 4th day of the study 0,4 ml/kg CCl 4 were given intraperitoneally (i.p.) to all groups except the control group. In Groups 3, 4, 5 and 6; 150 mg/kg/day C vitamine, 10 mg/kg/day MLT, 150 mg/ kg/day NAC and C vitamine + MLT + NAC combination, respectively, were given for 7 days. The malondialdehyde (MDA) level and superoxide dismutase (SOD), glutatyon peroxidase (GSH-Px), catalase (CAT) and myeloperoxidase (MPO) activities were measured in the tissues of liver and kidney of the mice. Results:The MDA and MPO levels in the tissues of liver and kidney of the toxicity group (Group 2) were significantly higher than those of the control group (p<0.01), but the GSH-Px and CAT activities were significantly lower than those of the control group (p<0.01). Compared with the toxicity group; in groups 3, 5 and 6 liver MDA and MPO levels showed a significant decrease (p<0.05) while GSH-Px and SOD activities in group 4 and GSH-Px activity in group 5 showed a significant increase (p<0.05). In kidney, MDA levels in groups 3 and 5 and MPO levels in groups 4 and 6 showed a significant decrease (p<0.05). SOD in group 3; GSH-Px and CAT in group 4; GSHPx, SOD and CAT in group 5 and SOD activities in group 6 showed a significant increase. Conclusion:The results showed that C vitamine therapy and the combined therapy were effective in preventing oxidative stress in both liver and kidney while MLT increased antioxidant enzyme activities more effectively. Furthermore, NAC was more effective in preventing oxidative stress and increasing antioxidant enzyme activities.

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Reduction of carbon tetrachloride‐induced nephropathy by melatonin administration

Cited by 31 publications

References 42 publications

Melatonin attenuates methotrexate‐induced oxidative stress and renal damage in rats

Melatonin attenuates methotrexate‐induced oxidative stress and renal damage in rats

Melatonin prevents formaldehyde‐induced neurotoxicity in prefrontal cortex of rats: an immunohistochemical and biochemical study

Protective Effects of Antioxidants on the Experimental Liver and Kidney Toxicity in Mice

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