Differential effect of cyclo‐oxygenase inhibition on antigen‐ and ionophore‐induced release of slow reacting substance from fragmented guinea‐pig lung

Krell, Robert D.; Kusner, Edward J.

doi:10.1111/j.1476-5381.1984.tb16484.x

Cited by 10 publications

(2 citation statements)

References 21 publications

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“…The reason for the inability of NZ-107 to inhibit A23 187-induced SRS-A (or histamine) release is not clear but may be related to the fact that antigen-and A23187-induced SRS-A release occurs at different sites by different mechanisms in guinea-pig lung tissue. Antigen-induced SRS-A release is usually dependent upon mast cell activation (Krell & Kusner 1984), whereas that of A23 187 occurs not only in broncho-alveolar macrobages (Sirois 1980) but also in the pulmonary arteries $eisch & Haisch 1982). However, a lipoxygenase inhibitor, NJDGA, inhibited both antigen-and A231 87-induced SRS-A From these results, it is possible that NZ-107 blocked the release of arachidonic acid after antigen-antibody binding or that NZ-107 selectively inhibited the lipoxygenase pathway activated by antigen.…”

Section: Discussionmentioning

confidence: 99%

Effect of an Anti-SRS-A Agent, NZ-107, on Airway Responses Induced by Ovalbumin and A23187 in the Guinea-pig

Yamamoto

Shikada

Iwama

et al. 1991

Journal of Pharmacy and Pharmacology

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The effects of the anti-SRS-A agent NZ-107 on antigen-(ovalbumin) and calcium ionophore A23187-induced airway responses in the guinea-pig have been investigated. In the presence of 5 microM indomethacin, NZ-107 (3 microM) did not affect the peak response in ovalbumin-induced contraction but did inhibit the prolonged response following the peak response in the tracheal strip. A higher concentration of NZ-107 (10 microM) completely blocked both peak and prolonged responses. Inhibitory effects of NZ-107 on ovalbumin responses were less in the lung parenchymal strip. The potency of NZ-107 in inhibiting ovalbumin-induced tracheal contraction was not changed in the absence of indomethacin but was reduced in the presence of 45 mM serine-borate, an inhibitor of the conversion of LTC4 to LTD4. NZ-107 inhibited A23187-induced contractions in both tracheal and parenchymal strips but in both cases the inhibitory potency was less than that on ovalbumin response. NZ-107 was a more potent inhibitor of ovalbumin-induced SRS-A release than histamine release in lung fragments but was ineffective in inhibiting A23187-induced SRS-A and histamine release. NZ-107 at a concentration of 10 microM more effectively inhibited LTC4- and histamine-induced tracheal contractions than it did LTC4 in the presence of 45 mM serine-borate. These results suggest that NZ-107 selectively inhibits antigen-induced SRS-A responses in airway tissues of the guinea-pig.

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Section: Discussionmentioning

confidence: 99%

Effect of an Anti-SRS-A Agent, NZ-107, on Airway Responses Induced by Ovalbumin and A23187 in the Guinea-pig

Yamamoto

Shikada

Iwama

et al. 1991

Journal of Pharmacy and Pharmacology

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“…They are synthesized de novo on exposure to immunological or non-immunological stimuli [68,69]. SRS-A is a major mediator released during guinea pig anaphylaxis and the guinea pig model has been used extensively in the study of pulmonary anaphylaxis both in vivo and in vitro [70][71][72][73][74]. SRS-A is released from the human lung mast cells on antigen challenge.…”

Section: B Mediators Released From Lung (I) Histaminementioning

confidence: 99%