Differential effect on survival of pelvic lymph node dissection at radical cystectomy for muscle invasive bladder cancer

Larcher, Alessandro; Sun, Maxine; Schiffmann, Jonas; Tian, Zhe; Shariat, Shahrokh F.; McCormack, Michael; Saad, Fred; Fossati, Nicola; Abdollah, Firas; Briganti, Alberto; Buffi, Nicolò Maria; Graefen, Markus; Guazzoni, G.; Montorsi, Francesco; Karakiewicz, Pierre I.

doi:10.1016/j.ejso.2014.10.061

Cited by 37 publications

(21 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For patients with different age and comorbidity status, the beneficial effect of PLND was also different. Larcher et al (17) found that RC with PLND is associated with improved cancer specific survival relative to RC alone, in younger and healthier RC candidates but not in older and sicker patients. From our study, although the number of PLND was less in the ELRC group, the lymph node status and the survival rate were similar in the two groups.…”

Section: Discussionmentioning

confidence: 99%

Extraperitoneal versus transperitoneal laparoscopic radical cystectomy for selected elderly bladder cancer patients: a single center experience

Feng

Song

et al. 2016

Int. braz j urol.

View full text Add to dashboard Cite

Objective:This study reports the initial experience of extraperitoneal laparoscopic radical cystectomy (ELRC) and compared with transperitoneal laparoscopic radical cystectomy (TLRC) in the treatment of selected elderly bladder cancer patients.Patients and Methods:A total of forty male bladder cancer patients who underwent ELRC (n=19) or TLRC (n=21) with ureterocutaneostomy were investigated. Demographic parameters, perioperative variables, oncological outcomes and follow-up data were retrospectively analyzed.Results:A significantly shorter time to exsufflation (1.5±0.7 vs 2.1±1.1 d; p=0.026) and liquid intake (1.8±0.9 vs 2.8±1.9 d; p=0.035) were observed in the ELRC group compared with the TLRC group. The incidence of postoperative ileus in the ELRC group was lower than the TLRC group (0 vs 9.5%). However, the difference had no statistical significance (p>0.05). The removed lymph node number in the ELRC group was significantly lower than the TLRC group (p<0.001). No significant differences were observed between the two groups in the overall and cancer-free survival rates (p>0.05).Conclusions:ELRC seems to be a safe and feasible surgical strategy for the selected elderly bladder cancer patients with ≤ T2 disease. The surgical and oncological efficacy of the ELRC is similar to that of the TLRC, but with faster intestinal function recovery. Further studies with a large series including different urinary diversions are needed to confirm our results and to better evaluate the benefit of ELRC in bladder cancer patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Extraperitoneal versus transperitoneal laparoscopic radical cystectomy for selected elderly bladder cancer patients: a single center experience

Feng

Song

et al. 2016

Int. braz j urol.

View full text Add to dashboard Cite

show abstract

“…It is clear that a pelvic lymph node dissection with RC provides a survival advantage compared to RC alone. [19] There are many studies which suggest a direct correlation between the increasing numbers of lymph nodes removed and improved survival. [1920] Hence, the remaining question is: does a formal ePLND provide a survival advantage?…”

Section: Advances In Surgery For Muscle Invasive Bladder Cancermentioning

confidence: 99%

“…[19] There are many studies which suggest a direct correlation between the increasing numbers of lymph nodes removed and improved survival. [1920] Hence, the remaining question is: does a formal ePLND provide a survival advantage? In a recent meta-analysis reported on over 2800 patients who underwent pelvic lymph node dissection, those who had ≥ pT3 disease had a significant benefit in recurrence-free survival with ePLND, HR: 0.61 (95% CI: 0.52–0.73), P < 0.001, but the same did not hold true for those with ≤ pT2 disease, HR: 0.95 (95% CI 0.64–1.41), P = 0.81.…”

Section: Advances In Surgery For Muscle Invasive Bladder Cancermentioning

confidence: 99%

Advances in surgical management of muscle invasive bladder cancer

Kukreja

Shah

2017

Indian J Urol

View full text Add to dashboard Cite

Introduction:Bladder cancer remains a disease of the elderly with relatively few advances that have improved survival over the last 20 years. Radical cystectomy (RC) has long remained the principal treatment for muscle-invasive bladder cancer (MIBC).Methods:A literature search of PubMed was performed. The content was reviewed for continuity with the topic of surgical advances in MIBC. Articles and society guidelines were included in this review.Results:Despite the associated morbidity, even in the elderly, RC is still a reasonable option. Modifications during RC may have a positive or negative impact on survival and quality of life. The extent of pelvic lymph node dissection is one such factor which may positively impact survival outcomes. In addition, preservation of pelvic organs, robotic surgery and the adoption of enhanced recovery after surgery principles continues to improve the postoperative recovery and quality of life in RC patients.Conclusion:There are some ongoing studies in many of these areas, but overall the new advances in MIBC may improve patient quality and quantity of life. The advances in surgical treatment of MIBC are important and the focus of the review here.

show abstract

“…The therapeutic value of any PLND at RC over cystectomy alone has never been investigated in a randomized fashion. Just two population‐based studies reported long‐term OS for patients with or without a PLND at RC . The 10‐year OS rates after PLND were 7–11% higher than for RC without PLND.…”

Section: Multivariable Cox Regression Analyses Predicting Os In 6415 mentioning

confidence: 99%

“…Just two population-based studies reported long-term OS for patients with or without a PLND at RC. 3,4 The 10-year OS rates after PLND were 7-11% higher than for RC without PLND. We estimated the therapeutic value of PLND on a nationwide basis in the Netherlands.…”

mentioning

confidence: 99%

Extended pelvic lymph node dissection at radical cystectomy for bladder cancer improves survival: Results of a nationwide population‐based study

et al. 2016

View full text Add to dashboard Cite

Differential effect on survival of pelvic lymph node dissection at radical cystectomy for muscle invasive bladder cancer

Cited by 37 publications

References 19 publications

Extraperitoneal versus transperitoneal laparoscopic radical cystectomy for selected elderly bladder cancer patients: a single center experience

Extraperitoneal versus transperitoneal laparoscopic radical cystectomy for selected elderly bladder cancer patients: a single center experience

Advances in surgical management of muscle invasive bladder cancer

Extended pelvic lymph node dissection at radical cystectomy for bladder cancer improves survival: Results of a nationwide population‐based study

Contact Info

Product

Resources

About