Differential effects of amphetamine and food deprivation on self-stimulation of the lateral hypothalamus and medial frontal cortex.

Abstract

Intracranial self-stimulation of the lateral hypothalamus of the rat was markedly increased by d-amphetamine administration and by food deprivation. In contrast, similar self-stimulation response rates obtained in the same animals from the medial frontal cortex were unaffected by food deprivation and only slightly increased by d-amphetamine administration. Furthermore, a large difference between d-vs. Z-amphetamine on response rate was obtained for lateral hypothalamic but not for medial frontal cortex self-stimulation. The results of this study were consistent with a noradrenergic self-stimulation system for the lateral hypothalamus. Medial frontal cortex self-stimulation, however, appears to be mediated by a neuroanatomical and neurochemical system different from that of the lateral hypothalamus.

Effects of food and water deprivation on self-stimulation of the medial and sulcal prefrontal cortex and caudate putamen in the rat

“…Since a subsequent experiment performed with the same animals showed a specific increase in self-stimulation rate of caudate-putamen in the majority of the aimals (48), such an effect is unlikely for that structure. Ceiling effects cannot be excluded, however, for the prefrontal cortex, although our results in this structure are consistent with those mentioned by other authors [3,5]. Our main conclusion, therefore, is that self-stimulation of the sulcal prefrontal cortex is influenced in some way by factors controlling food intake.…”

The effect of chronic amphetamine treatment on cocaine-induced facilitation of intracranial self-stimulation in rats

“…Acutely, amphetamine facilitates ICSS (Carey and Goodal 1975; Esposito et al. 1980; Lin et al 2000; Schmidt et al 2012; Bauer et al 2013), and effects of chronic amphetamine in this study are similar to effects described previously using other ICSS procedures (Lin et al 2000; Paterson et al 2000; Anderson et al 1978).…”

Effect of food and water deprivation on hippocampal self-stimulation and poststimulation feeding

“…This suggestion is unlikely in view of other research indicating that water deprivation has no effect on hypothalamic self-stimulation (e.g., Annau & Baetjer, 1971;Carey, Goodall, & Lorens, 1975;Mogenson, 1969). It is, nevertheless, possible that a deprivation effect might have been obscured by the procedures used in these studies.…”