Effects of food and water deprivation on self-stimulation of the medial and sulcal prefrontal cortex and caudate putamen in the rat

Prefrontal cortex self-stimulation and energy balance.

“…This facilitation is evident from both the increased self-stimulation rates and decreased self-stimulation thresholds in the SPC group. However, the effects on rates are considerably smaller than those reported by Koolhaus et al (1977), who used a CRF schedule. These investigators reported approximate 100% and 200% facilitations of SPC self-stimulation rates after 24 and 48 hr of food deprivation, respectively.…”

“…This would be similar to previous results with LH self-stimulation for which only 48 hr of deprivation produced a facilitation of rates when a fixed-interval schedule of reinforcement was used (Atrens et al, 1982). However, it is also worth noting that testing in the Koolhaus et al (1977) experiment occurred near the beginning of the dark phase of a reversed light–dark cycle. Because this is normally a time of peak food intake, it may be that food deprivation has greater effects on SPC self-stimulation at this time.…”

“…In the present study, the dissociation between MFC and SPC self-stimulation in relation to energy balance was further explored. We attempted to confirm the previous report that SPC but not MFC self-stimulation is facilitated by food de-privation (Koolhaus et al, 1977). Furthermore, the effects of 2-deoxy-D-glucose (2-DG) and insulin, both of which increase food intake, were assessed to determine whether druginduced glucoprivation would modulate PFC self-stimulation.…”

“…It has been reported that self-stimulation of the SPC but not the MPC or striatum is facilitated by food deprivation (Koolhaus et al, 1977). Other studies have also reported no effect of food deprivation on MPC self-stimulation (Carey, Goodall, & Lorens, 1975; Goodall & Carey, 1975).…”

“…MPC self-stimulation is facilitated after acute stress (McGregor & Atrens, 1990; McGregor, Balleine, & Atrens, 1989), whereas stress inhibits SPC self-stimulation (McGregor, in press). On the other hand, food deprivation facilitates SPC but not MPC self-stimulation (Koolhaus, Mora, & Phillips, 1977).…”