Prefrontal cortex self-stimulation and energy balance.

McGregor, Iain S.; Atrens, Dale M.

doi:10.1037/0735-7044.105.6.870

Cited by 14 publications

(2 citation statements)

References 67 publications

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“…In particular, prefrontal cortex self-stimulation induced feeding and weight gain over several weeks of exposure to stimulation. Overall, it appears that prefrontal cortex self-stimulation modulates energy balance (McGregor and Atrens 1991). The use of moderate stimulation by threshold currents in the present work confirms the data obtained.…”

Section: Discussionsupporting

confidence: 90%

Role of orexin peptide system in emotional overeating induced by brain reward stimulation in fed rats

Lebedev¹,

Bessolova²,

Efimov³

et al. 2020

RRP

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Citation: Lebedev AA, Bessolova YuN , Efimov NS, Bychkov ER, Droblenkov AV, Shabanov PD (2020) Role of orexin peptide system in emotional overeating induced by brain reward stimulation in fed rats. Research Results in Pharmacology 6(1): 81-91. AbstractIntroduction: The purpose of this work was to prove that the reaction of food self-deprivation in "fed up" rats is a suitable model for studying the emotional overeating in the experiment. Methods:The self-deprivation reaction, i.e. self-isolation of an animal from food during electrical self-stimulation of the brain, was studied in animals with food deprivation. To reproduce the self-stimulation of the lateral hypothalamus, the male Wistar rats were trained to press a pedal in a Skinner box. After training, the rats received food deprivation, then a feeder was placed in the Skinner box, and a conditioned food reflex was developed in rats within 5 days. Results and discussion:The food self-deprivation reaction was observed in the "satiated" rats with a current intensity of 10% and above the threshold for self-stimulation. Hungry animals pressed the pedal for hypothalamic self-stimulation and took no notice of the feeding trough. Sulpiride, a dopamine D2 antagonist (5 and 20 mg/kg i.p.), administered to the "satiated" rats decreased both the eating behavior and self-stimulation in food self-deprivation testing. SB-408124, an orexin A receptor antagonist (0.5 mg/ml, 20 μl intranasally) reduced only the number of pellets eaten, but not the number of pedal presses. Conclusion:The orexin A receptors are preferably involved in emotional eating compared with orexin B (OX2R TCS-OX2-29) and D2 dopamine receptors. Because emotional eating is significantly related to clinical eating disorders, like bulimia and binge eating disorder, it seems promising to use drugs of the orexin system to treat and prevent the issue.

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Section: Discussionsupporting

confidence: 90%

Role of orexin peptide system in emotional overeating induced by brain reward stimulation in fed rats

Lebedev¹,

Bessolova²,

Efimov³

et al. 2020

RRP

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“…Many rostral brain areas support self-stimulation, including the olfactory bulb (Phillips, 1970), prefrontal cortex, posterior medial cingulate cortex (Routtenberg & Sloan, 1972), MPFC (Ferrer, Cobo, & Mora, 1987; Ferrer, Sanguinetti, Vives, & Mora, 1983; Schenk & Shizgal, 1982; Trzcińska & Bielajew, 1992), sulcal prefrontal cortex (Clavier & Gerfen, 1979; McGregor & Atrens, 1991), pyriform cortex (Prado-Alcala, Streather, & Wise, 1984), entorhinal cortex (Ott, Destrade, & Ruthrich, 1980) and medial entorhinal cortex (Reymann, Mulcko, & Matthies, 1986). In addition, self-stimulation can be obtained from noncortical forebrain structures, such as a number of thalamic nuclei (Bielajew & Fouriezos, 1985; Vachon & Miliaressis, 1992), nucleus accumbens (Fouriezos, Walker, Rick, & Bielajew, 1987), caudate–putamen (CPu; Phillips, Carter, & Fibiger, 1976; Prado-Alcala, Kent, & Reid, 1975; Routtenberg, 1971; Trzcińska & Bielajew, 1992), and ventral pallidum (Panagis, Miliaressis, Anagnostakis, & Spyraki, 1995).…”

mentioning

confidence: 99%

Functional connections between medial prefrontal cortex and caudate-putamen in brain-stimulation reward of rats.

Trzcińska¹,

Bielajew²

1998

Behavioral Neuroscience

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Rats were trained to self-stimulate for trains of cathodal pulses delivered via electrodes placed in the medial prefrontal cortex (MPFC) and caudate-putamen (CPu). When the pulses were delivered via 9 ipsilateral MPFC and CPu sites alternately, summation varied from 13% to 40%. However, the overall summation for 2 contralateral MPFC-CPu pairs was 5%, thus indicating a greater integration of ipsilateral than contralateral reward signals. When the interval between alternate pulses decreased in 4 of the 9 ipsilateral pairs, the summation also decreased, an outcome consistent with collision of action potentials passing between the MPFC and CPu sites. The size of the collision effect ranged from 15% to 33%. Estimates of conduction velocity varied between 0.4 to 5.4 m/s, with a 1.7 m/s average. According to these values, the neurons connecting the MPFC and CPu self-stimulation sites appear to be slower than the ones that have been shown to link reward fibers that course between posterior brain regions.

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Conditioned place preference induced by electrical stimulation of the insular cortex: effects of naloxone

2013

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The insular cortex has been related to various sensory, regulatory, and learning processes, which frequently include affective-emotional components. The objective of this study was to investigate the possibility of inducing reinforcing effects by electrical stimulation of this cortical region in Wistar rats. Concurrent conditioned place preference tasks were conducted for this purpose, using two rectangular mazes that differed in dimensions, texture, and spatial orientation. A significant correlation was found in the preferences induced by insular cortex electrical stimulation between the two mazes. Animals showed consistent preference or avoidance behaviors associated with simultaneous insular cortex stimulation. No electrical self-stimulation was achieved. In a second experiment, animals that showed consistent place preference after the simultaneous insular cortex electrical stimulation were administered with 4 mg/ml/kg of naloxone. The results revealed that this opiate antagonist blocked concurrent place preference learning when the task was conducted in a new maze but not when it was conducted in the same maze as that in which the animals had learned the task. These results are discussed in terms of the participation of the insular cortex in various reward and aversion modalities.

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Prefrontal cortex self-stimulation and energy balance.

Cited by 14 publications

References 67 publications

Role of orexin peptide system in emotional overeating induced by brain reward stimulation in fed rats

Role of orexin peptide system in emotional overeating induced by brain reward stimulation in fed rats

Functional connections between medial prefrontal cortex and caudate-putamen in brain-stimulation reward of rats.

Conditioned place preference induced by electrical stimulation of the insular cortex: effects of naloxone

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