Differential effects of bupropion on acquisition and performance of an active avoidance task in male mice

Gómez, Mercedes; Redolat, Rosa; Carrasco, M.C.

doi:10.1016/j.beproc.2015.12.003

Cited by 4 publications

(1 citation statement)

References 48 publications

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“…injection of either 20 mg/kg (N=16) or 40 mg/kg (N=16) of BUP or a similar volume (5 ml/kg) of 0.9% saline (N=16), the vehicle group. These doses were chosen based on a previous study that assessed the ability of BUP to improve active avoidance conditioning in mice (Gomez et al, 2016). Mice were returned to their home cages and given 20% ethanol access for 2-hours.…”

Section: Experiments 1: Effect Of Bupropion On Binge-like Ethanol Intamentioning

confidence: 99%

Bupropion, Alone and in Combination with Naltrexone, Blunts Binge‐Like Ethanol Drinking and Intake Following Chronic Intermittent Access to Ethanol in Male C57BL/6J Mice

Navarro

Luhn

Kampov‐Polevoy

et al. 2019

Alcoholism Clin & Exp Res

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Background: Regular binge drinking is associated with numerous adverse consequences yet the U.S. Food and Drug Administration (FDA) has approved only 4 medications for the treatment of alcohol use disorders (AUDs), and none have been specifically targeted for treating binge drinking. Here we assessed the effectiveness of the dopamine/norepinephrine reuptake inhibitor, bupropion (BUP), alone and in combination with naltrexone (NAL), to reduce binge-like and chronic ethanol intake in mice. While BUP is an FDA-approved drug that is currently used to treat depression and nicotine dependence there has been only limited investigation to assess the ability of BUP to reduce ethanol intake. Methods: Male C57BL/6J mice were tested with 20% (v/v) ethanol using "drinking in the dark" (DID) procedures to model binge-like ethanol intake and following intermittent access to ethanol (IAE). In Experiment 1, mice were given intraperitoneal (i.p.) injection of 0, 20, or 40 mg/kg BUP 30-min before DID testing, in Experiment 2 mice were given i.p. injection of vehicle, BUP (20 mg/kg), NAL (3 mg/kg), or BUP + NAL (20 and 3 mg/kg, respectively) 30 min before DID testing, and in Experiment 3 mice were given i.p. injection of 0, 20, 40 or 60 mg/kg BUP 30-min before ethanol access after mice had 16-weeks of IAE. Results: BUP dose-dependently blunted ethanol intake with DID procedures and after 16-weeks of IAE. Administration of subthreshold doses of BUP + NAL also reduced binge-like ethanol intake. Finally, BUP failed to reduce consumption of a 3% (w/v) sucrose solution.

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Section: Experiments 1: Effect Of Bupropion On Binge-like Ethanol Intamentioning

confidence: 99%

Bupropion, Alone and in Combination with Naltrexone, Blunts Binge‐Like Ethanol Drinking and Intake Following Chronic Intermittent Access to Ethanol in Male C57BL/6J Mice

Navarro

Luhn

Kampov‐Polevoy

et al. 2019

Alcoholism Clin & Exp Res

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show abstract

Adolescent and adult mice display differential sensitivity to the effects of bupropion on the acquisition of a water maze task

Gómez

Carrasco

Redolat

2017

Pharmacological Reports

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The effect of paroxetine, venlafaxine and bupropion administration alone and combined on spatial and aversive memory performance in rats

Menezes

McIntyre

Filho

et al. 2018

Pharmacological Reports

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Differential effects of bupropion on acquisition and performance of an active avoidance task in male mice

Cited by 4 publications

References 48 publications

Bupropion, Alone and in Combination with Naltrexone, Blunts Binge‐Like Ethanol Drinking and Intake Following Chronic Intermittent Access to Ethanol in Male C57BL/6J Mice

Bupropion, Alone and in Combination with Naltrexone, Blunts Binge‐Like Ethanol Drinking and Intake Following Chronic Intermittent Access to Ethanol in Male C57BL/6J Mice

Adolescent and adult mice display differential sensitivity to the effects of bupropion on the acquisition of a water maze task

The effect of paroxetine, venlafaxine and bupropion administration alone and combined on spatial and aversive memory performance in rats

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