Differential effects of morphine andd-amphetamine on self-stimulation from closely adjacent regions in rat midbrain

Liebman, Jeffrey M.; Segal, David S.

doi:10.1016/0006-8993(77)90135-4

Cited by 24 publications

(1 citation statement)

References 31 publications

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“…DPT and MPG ICSS sites have been shown to respond differentially to lesion, pharmacological, and interaction manipulations (Clavier & Corcoran, 1976;Ellman, Ackermann, Bodnar, laclder, & Steiner, 1976;Liebman & Segal, 1977;Phillips, Brooke, & Fibiger, 1975;Phillips & Fibiger, 1973;Bodnar, Ackermann, Ippolito, Nelson, Healey, Brutus, Ellman, & Steiner, Note 2). However, no differences in ICSS responding at any CoT interval were observed in comparing 16 DPT electrode sites and 5 MPG electrode placements.…”

Section: Icss Cot Responsivity Within Met-mesencephalic Locimentioning

confidence: 99%

Monophasic pulse pair analysis of intracranial self-stimulation loci

et al. 1978

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Monophasic pulse pair stimulation, traditionally used to determine the refractory characteristics of peripheral nervous system neurons, has been modified for the same purpose in intracranial self-stimulation (lCSS) behavior. When the interval between pulses in a pair (C-T interval) is systematically varied, ICSS response rates change as a function of this variation. The present study evaluated alterations in the CoT interval/ICSS response rate function across ICSS loci and across stimulation conditions. Diencephalic sites supported peak ICSS responding at significantly shorter CoT intervals than met-mesencephalic or telencephalic sites. Despite previously cited differences in ICSS behavior observed within diencephalic and within met-mesencephalic loci, no differences in ICSS responding across CoT intervals were observed within diencephalic and met-mesencephalic sites. Moreover, diencephalic sites produced peak ICSS responding at shorter CoT intervals when cathodal and anodal sources were distant than when they were adjacent; the relative proximity of cathodal and anodal sources did not affect met-mesencephalic ICSS behavior. These results suggest that alterations in ICSS responding across CoT intervals are due to differences in the locus and density of ICSS neurons in the cathodal field and the presence and/or absence of adjacent anodal influences as well as the refractory characteristics of the ICSS neurons.The monophasic stimulation technique was initially employed to determine the refractory characteristics of peripheral nervous system neurons (Erlanger & Gasser, 1937;Lloyd, 1946;Sherrington, 1906). A pair of brief (0.1 msec) monophasic rectangular electrical pulses, the first of which was designated the C pulse and the second, the T pulse, would be temporally varied with respect to one another (C-T interval) during stimulation of peripheral nerves, allowing the estimation of their conduction velocity and axonal refractory periods.Deutsch (I964) modified this basic technique in order to approximate the refractory characteristics of the neurons subserving intracranial self-stimulation (lCSS) behavior. Since ICSS behavior could not be sustained by delivery of single pulse pairs as the reinforcer, Deutsch had to use trains of the monophasic pulse paii stimulation with the temporal distance between succeeding pulse pairs designated the C-C interval. To determine refractory period estimations, Deutsch varied stimulus intensities so that C-C stimulation (T pulses omitted) supported minimal ICSS rates while the same stimulus parameters with the T pulses spaced midway between the C pulses (Le.,

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