Differential effects of physical exercise and<scp>l</scp>-arginine on cortical spreading depression in developing rats

Monteiro, Heloísa Mirelle Costa; Silva, Débora de Lima e; França, João Paulo Bernardo Dantas de; Maia, Luciana Maria; Angelim, Monara Kaélle Sérvulo Cruz; Amâncio-dos-Santos, Ângela; Guedes, Rubem Carlos Araújo

doi:10.1179/1476830511y.0000000008

Cited by 8 publications

(6 citation statements)

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“…Additionally, Gollisch et al (2009) found no weight alteration in rats engaging in exercise on wheels and suggested that a significantly higher caloric intake probably compensated for the higher energy expenditure from the exercise. The current results also confirm a previous study from our group of no difference in body weight between exercised and sedentary young rats (Monteiro et al, 2011).…”

Section: Discussionsupporting

confidence: 95%

“…Exercise alone does so, as well, in agreement with previous studies showing that physical exercise can antagonize CSD propagation (Batista-de-Oliveira et al, 2012; Monteiro et al, 2011). Those studies involved a similar protocol of treadmill physical exercise, but the exercise was performed in rats in an earlier phase of life (15-35 days of life) than in the current work.…”

Section: Discussionsupporting

confidence: 93%

“…Periods of treadmill exercise lasted 3 weeks, 30 min per day, in 5 weekly sessions (one session per day). The treadmill running velocity was set at 5 m/min during the first week; during the second and third weeks, the velocity was increased to 10 m/min and 15 m/min, respectively (Monteiro et al, 2011). Rats from the sedentary groups (water-only and fluoxetine-only groups) were placed in the treadmill for the same period as the exercised animals, but the treadmill was turned off.…”

Section: Fluoxetine Administration and The Treadmill Exercise Protocolmentioning

confidence: 99%

“…Rats performed physical exercise on a treadmill during early phases of development, at adulthood, or during senescence. At all ages, an antagonistic effect of exercise on CSD was observed (Batista-de-Oliveira et al, 2012;Monteiro et al, 2011). These data led us to ask the following questions: (1) Can physical exercise potentiate the effect of 10 mg/kg fluoxetine on CSD?…”

Section: Introductionmentioning

confidence: 98%

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Physical exercise versus fluoxetine: Antagonistic effects on cortical spreading depression in Wistar rats

Monteiro

Barreto-Silva

Santos

et al. 2015

European Journal of Pharmacology

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The antidepressant fluoxetine and physical exercise exert similar effects on the serotoninergic system by increasing brain serotonin availability, and both show antagonistic action on cortical excitability. Here we provide the first assessment of the interaction of the two together on cortical spreading depression (CSD) in young adult rats. Wistar rats (40-60 days of life) received fluoxetine (10mg/kg/d, orogastrically) or an equivalent volume of water. Half of the animals from each condition were assigned to perform physical exercise in a treadmill, and the other half formed the sedentary (non-treadmill) control groups. Body parameters (Lee index and thoracic and abdominal circumferences) and the velocity of CSD propagation were investigated. Fluoxetine+exercise animals had less weight gain (78.68±3.19g) than either the fluoxetine-only (93.34±4.77g) or exercise-only group (97.04±3.48g), but body parameters did not differ among them. The velocity of CSD propagation was reduced in the fluoxetine-only and exercise-only groups compared to sedentary water controls (3.24±0.39mm/min). For the fluoxetine+exercise group, CSD velocity values were significantly lower (2.92±0.22mm/min) than for fluoxetine only (3.03±0.35mm/min); however, they were similar to values for the exercise-only group (2.96±0.23mm/min). These findings confirm the similar effects of fluoxetine and exercise and suggest a greater effect of physical exercise in reducing brain excitability.

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Section: Discussionsupporting

confidence: 95%

Section: Discussionsupporting

confidence: 93%

Section: Fluoxetine Administration and The Treadmill Exercise Protocolmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Physical exercise versus fluoxetine: Antagonistic effects on cortical spreading depression in Wistar rats

Monteiro

Barreto-Silva

Santos

et al. 2015

European Journal of Pharmacology

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“…The L-arginine or water were daily administered through gavage from the seventh to the 35 th day of life, between six and eight o'clock. The total volume administered in each gavage ranged from 0.5 ml/ day (seventh to 14th day of life of the animal) to 1.0 ml/day (15th to 35th day of life of the animal) 12 .…”

Section: Methodsmentioning

confidence: 99%

Interferência da L-arginina e do exercício físico sobre a morfologia do músculo estriado esquelético em ratos jovens

Melo

Vasconcelos

Santos

et al. 2013

Rev Bras Med Esporte

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Introduction: Exercise and the amino acid L-Arginine can promote anatomical and physiological changes in the skeletal muscle. Objective: The objective of this work was to analyze the influence of L-arginine associated with exercise in the skeletal muscle fibers. Methods: To carry out our research, 24 male Wistar rats divided into 4 groups according to the administration of Arginine and physical exercise were used. The experimental groups were distributed as follows: Arginine-Exercise (AE, n = 6), Arginine--Not Exercised (AN, n = 6), Water-Exercise (WE, n = 6) and Water-Not Exercised (WN, n = 6). The amino acid L-Arginine was administered via orogastric intubation, at dose of 300mg/kg, daily from the 7th to 35th days of life of the animal. The exercise was performed on motorized treadmill for 30 minutes/day, 5 times a week, from 15th to 35th days of life of the animal. At the age of 35-45 days, the animals were weighed and sacrificed in order to collect the gastrocnemius muscle. The gastrocnemius muscle was measured, weighed and processed for histological analysis. The muscle's images were taken in order to calculate the mean diameter of the muscle fiber. Data were expressed as mean ± standard deviation and analyzed using SPSS. The Shapiro-Wilk, one-way ANOVA and Tukey's tests (p <0.05) were applied. Results: Concerning body weight and gastrocnemius weight, there was no significant difference when all the experimental groups were compared. However, the AN group presented the highest mean diameter when compared to the other groups. Conclusion: This fact suggests that orogastric administration of Arginine offered to the animals that were not exercised, promotes muscle hypertrophy. On the other hand, exercise by itself did not lead to increase in mean diameter of the skeletal muscle.

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Revisiting the effects of exercise on cerebral neurovascular functions in rats using multimodal assessment techniques

Yen¹,

Wu²,

Wang³

et al. 2023

iScience

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Differential effects of physical exercise andl-arginine on cortical spreading depression in developing rats

Abstract: L-arginine and exercise affect CSD differentially (L-arginine accelerated, while exercise decelerated CSD), and both effects did interact. Probably, they depend on developmental plasticity changes associated with the treatments.

Cited by 8 publications

References 50 publications

Physical exercise versus fluoxetine: Antagonistic effects on cortical spreading depression in Wistar rats

Physical exercise versus fluoxetine: Antagonistic effects on cortical spreading depression in Wistar rats

Interferência da L-arginina e do exercício físico sobre a morfologia do músculo estriado esquelético em ratos jovens

Revisiting the effects of exercise on cerebral neurovascular functions in rats using multimodal assessment techniques

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