Differential effects of propofol and isoflurane on the activation of T‐helper cells in lung cancer patients

Ren, Xuan; Li, W. Z.; Meng, Fei; Lin, Changfu

doi:10.1111/j.1365-2044.2010.06304.x

Cited by 78 publications

(59 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The activation and differentiation of T lymphocytes is required for anti-infection and anti-tumor immune responses (6). In addition, an imbalance in the relative levels of the various T-helper (Th) cells, including Th 1 , Th 2 and Th 17 cells, and regulatory T (T reg ) cells, has been associated with immunological disturbances (7).…”

Section: Introductionmentioning

confidence: 99%

Effects of transcutaneous acupoint electrical stimulation on the imbalance of Th1, Th2, Th17 and Treg cells following thoracotomy of patients with lung cancer

Wang

et al. 2015

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. An imbalance in the various T lymphocytes, including T-helper (Th) 1 , Th 2 and Th 17 cells, and regulatory T (T reg ) cells, has been associated with immune dysfunction, and may occur following thoracotomy of patients with lung cancer. The use of transcutaneous acupoint electrical stimulation (TAES) has previously been demonstrated to exert immunoregulatory effects; therefore, the present study aimed to evaluate whether TAES was able to attenuate postoperative immune suppression in patients with lung cancer. Thoracic surgical patients with lung cancer (n=27) underwent TAES (frequency, 2/100 Hz; intensity, 4-12 mA) at the bilateral large intestine 4, pericardium 6, small intestine 3 and San Jiao 6 acupuncture points for 30 min, prior to incision, and at 20, 44, 68, 92 and 116 h following thoracotomy. The number of Th 1 , Th 2 , Th 17 and T reg cells, and the protein and mRNA expression levels of related cytokines were measured by flow cytometry, ELISA and polymerase chain reaction, respectively. The balance of Th 1 , Th 2 , Th 17 and T reg cells in the peripheral blood of patients with lung cancer was disrupted following thoracotomy. TAES administration increased the percentage of Th 1 and Th 17 cells, the protein expression levels of interleukin (IL)-2 and interferon-γ, the mRNA expression levels of T-bet and RAR-related orphan receptor-γt, and decreased the percentage of Th 2 cells, IL-10 protein expression levels, and GATA binding protein 3 mRNA expression levels. The results of the present study demonstrated that TAES was able to partially attenuate the postoperative immune depression of patients with lung cancer, by regulating the balance of Th 1 , Th 2 , Th 17 and T reg cells, and the expression levels of related cytokines and transcription factors; therefore, TAES may be considered to be a promising strategy for treating postoperative immune dysfunction in patients with lung cancer.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of transcutaneous acupoint electrical stimulation on the imbalance of Th1, Th2, Th17 and Treg cells following thoracotomy of patients with lung cancer

Wang

et al. 2015

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

show abstract

“…Besides these, the results from Ren et al study showed that propofol promoted activation and differentiation of peripheral T-helper cells. The percentage of CD4(+ )CD28(+ ) and the ratio of INF-γ:IL-4 increase with propofol but showed no change with isoflurane in patients undergoing pulmonary lobectomy for non-smallcell lung cancer (14) . Inada et al found in patients undergoing craniotomy that propofol may be better than isoflurane in attenuating the surgical stress-induced adverse immune response (15).…”

Section: Discussionmentioning

confidence: 86%

Effects of Sevoflurane or Propofol on Immune Function in Patients Undergoing Hepatectomy

Gao¹,

Song²,

Zhang³

et al. 2017

J Anesth Perioper Med

View full text Add to dashboard Cite

“…Propofol (2,6-diisopropylphenol) is one of a number of extensively used intravenous anesthetic agents that also exhibit antitumor effects (26,27). Propofol, at clinically relevant concentrations, may inhibit tumor invasion and result in apoptosis of human cancer cells (28).…”

Section: Discussionmentioning

confidence: 99%

Anesthetic drug propofol inhibits the expression of interleukin‑6, interleukin‑8 and cyclooxygenase‑2, a potential mechanism for propofol in suppressing tumor development and metastasis

Liang

et al. 2018

Oncol Lett

View full text Add to dashboard Cite

Abstract. Previous studies have indicated that anesthesia-associated drugs may directly inhibit cellular immunity and humoral immunity, which may be associated with tumor recurrence. The present study demonstrated that propofol may suppress the proliferation of MCF-7 cells and inhibit the expression of interleukin (IL)-6 and IL-8. Subsequent to treatment with propofol, MCF-7 cells demonstrated downregulated cyclooxygenase-2 (COX-2) protein expression and decreased levels of vascular endothelial growth factor and prostaglandin E2 in the supernatant. Therefore, the mechanism of propofol in suppressing tumor development and metastasis may be associated with the inhibition of IL-6, IL-8 and COX-2.

show abstract

Differential effects of propofol and isoflurane on the activation of T‐helper cells in lung cancer patients

Cited by 78 publications

References 41 publications

Effects of transcutaneous acupoint electrical stimulation on the imbalance of Th1, Th2, Th17 and Treg cells following thoracotomy of patients with lung cancer

Effects of transcutaneous acupoint electrical stimulation on the imbalance of Th1, Th2, Th17 and Treg cells following thoracotomy of patients with lung cancer

Effects of Sevoflurane or Propofol on Immune Function in Patients Undergoing Hepatectomy

Anesthetic drug propofol inhibits the expression of interleukin‑6, interleukin‑8 and cyclooxygenase‑2, a potential mechanism for propofol in suppressing tumor development and metastasis

Contact Info

Product

Resources

About