Differential Effects of Respiratory Syncytial Virus and Adenovirus on Mononuclear Cell Cytokine Responses

Díaz, Patricia; Calhoun, William J.; Hinton, Kim L.; Avendaño, Luis F.; Gaggero, Aldo; Simon, Valeska; Arredondo, Sonia; Pinto, Ricardo A.; Diaz, Armando

doi:10.1164/ajrccm.160.4.9804075

Cited by 47 publications

(32 citation statements)

References 23 publications

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“…Previous studies demonstrated that IFN-c protein production did not increase in RSV infected peripheral blood MNCs. However, induction of IFN-c mRNA could be detected [18][19][20]. Therefore, the current study is generally consistent with these reports.…”

Section: Discussionsupporting

confidence: 92%

Cytokine production of RSV/PHA‐stimulated tonsillar mononuclear cells: influences of age and atopy

Ichinohe

Hussain²,

Johnston³

2003

Eur Respir J

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Links between immune responses to respiratory syncytial virus (RSV), age and atopic sensitisation are poorly understood.This study investigated the induction of target organ type-1, type-2 and proinflammatory cytokine responses to RSV and/or phytohaemagglutinin (PHA) in tonsillar mononuclear cells from children, in relation to age and atopic status.In comparison with the control medium, RSV induced production of the type-1 cytokines interferon (IFN)-c and interleukin (IL)-18, the pro-inflammatory cytokines IL-6, -8 and RANTES (regulated on activation, normal T-cell expressed and secreted), but not any of the type-2 cytokines IL-4, -5, -10 and -13. Induction of IL-6, -8 and RANTES, but not IFN-c or IL-18, were shown to be dependent on virus replication. PHA induced all except IL-12, -13, and -15. Induction of IFN-c, IL-6, -8, and RANTES was significantly increased in atopic children. Induction of both IFN-c and IL-4 increased in parallel in relation to age, with no change in the IFN-c:IL-4 ratio.These data are compatible with the hypothesis that immature type-1 immunity during early childhood plays a role in both respiratory syncytial virus bronchiolitis and in its relationship with atopy. Eur Respir J 2003; 22: 317-322.

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Section: Discussionsupporting

confidence: 92%

Cytokine production of RSV/PHA‐stimulated tonsillar mononuclear cells: influences of age and atopy

Ichinohe

Hussain²,

Johnston³

2003

Eur Respir J

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“…However, compared with other common upper respiratory tract infections such as adenovirus, rhinovirus, or influenza virus, RSV infection induces rather weak IFN-␥ responses (28,34,35). Increased severity of RSV infection is associated with decreased IFN-␥ levels in the airway (36,37).…”

mentioning

confidence: 99%

Human Metapneumovirus Elicits Weak IFN-γ Memory Responses Compared with Respiratory Syncytial Virus

Douville¹,

Bastien

et al. 2006

The Journal of Immunology

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Human metapneumovirus (MPV) is a recently discovered pathogen that causes repeated lower respiratory tract infections beginning in infancy. The prevalence, nature and control of human regulatory responses to MPV are unknown. In this study, we develop and optimize systems to evaluate MPV-driven cytokine responses. Using primary culture of human PBMC from previously exposed adults, MPV-stimulated responses were directly compared with those elicited by genetically and clinically similar respiratory syncytial virus (RSV). Intense IL-6 production was evident following culture with infectious or inactivated RSV. MPV elicited IL-6 responses averaging 3.5-fold more intense (p < 0.001). Virus-dependent expression of IL-11, IL-12, IFN-α, and other innate immunity cytokines differed little between MPV and RSV. When examining adaptive immunity, RSV infection elicited strong IFN-γ responses by all 60 adults. In marked contrast, MPV elicited IFN-γ in a lower frequency of adults (p < 0.002) and at levels averaging 6-fold weaker (p < 0.001). These Th1-dominated responses were CD4, CD8, CD86 dependent, and were closely paralleled by strong virus-driven IL-10 and CCL5 production. For MPV and RSV, Th2 (IL-5, IL-13) responses were sporadic, occurring in 10–40% of the population. Thus, MPV and RSV, although both ubiquitous and leading to very high levels of infection, seroconversion, and clinically similar presentation in the population, evoke distinct innate and adaptive T cell-dependent cytokine responses. Although both viruses yield Th1-dominated responses with strong IL-10 and CCL5 production, MPV restimulation results in markedly more robust IL-6 and significantly weaker adaptive cytokine responses, in both prevalence and intensity, than does RSV.

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“…The affected lung is usually small as the infection during childhood inhibited the normal growth pattern, with secondary hypoplasia of the pulmonary artery. A number of reports have described SJS that followed some episodes in childhood, including radiation therapy, measles, pertussis, tuberculosis, foreign body, mycoplasma and viral infections, especially adenovirus (13)(14)(15)(16). The bronchoalveolar lavage from SJS patients presents a significant increase of neutrophils and a slight increase of lymphocytes, suggesting a hyperimmune reaction in the lung which may play a role in sustaining peripheral airway damage after the initial infection (17).…”

Section: A B Cmentioning

confidence: 99%

Swyer-James Syndrome with Peculiar Course and Ipsilateral Pulmonary Vein Defect

et al. 2011

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Swyer-James syndrome (SJS) is a rare disease probably resulting from bronchiolitis obliterans. The radiological findings of this entity are characterized by hyperlucent appearance of one or more lobes of a unilateral lung, decreased lung volume, diminished ipsilateral hilar shadow and hardly visible arterial structure on chest radiography. We report a 50-year-old patient, who had unilateral right lower lung hyperlucency on chest radiography. However, the patient reported a history of pulmonary atelectasis of lobus centralis dexter in the course and the corresponding affliction of ipsilateral pulmonary vein, that rendered the diagnosis more complicated. The radiological and pathological features of this syndrome, as well as differential diagnosis were also discussed.

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Differential Effects of Respiratory Syncytial Virus and Adenovirus on Mononuclear Cell Cytokine Responses

Cited by 47 publications

References 23 publications

Cytokine production of RSV/PHA‐stimulated tonsillar mononuclear cells: influences of age and atopy

Cytokine production of RSV/PHA‐stimulated tonsillar mononuclear cells: influences of age and atopy

Human Metapneumovirus Elicits Weak IFN-γ Memory Responses Compared with Respiratory Syncytial Virus

Swyer-James Syndrome with Peculiar Course and Ipsilateral Pulmonary Vein Defect

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