Differential effects of sodium chloride and monosodium glutamate on kidney of adult and aging mice

Abstract

Monosodium Glutamate (MSG) is used as flavour enhancer, with potential beneficial effects due to its nutritional value. Given the decline in kidney functions during aging, we investigated the impact of MSG voluntary intake on the kidney of male mice, aged 6 or 18 months. For 2 months, they freely consumed water (control group), sodium chloride (0.3% NaCl) or MSG (1% MSG) in addition to standard diet. Young animals consuming sodium chloride presented signs of proteinuria, hyperfiltration, enhanced expression and excretion of Aquaporin 2 and initial degenerative reactions suggestive of fibrosis, while MSG-consuming mice were similar to controls. In old mice, aging-related effects including proteinuria and increased renal corpuscle volume were observed in all groups. At an advanced age, MSG caused no adverse effects on the kidney compared to controls, despite the presence of a sodium moiety, similar to sodium chloride. These data show that prolonged MSG intake in mice has less impact on kidney compared to sodium chloride, that already in young animals induced some effects on kidney, possibly related to hypertension.

Protective and/or Therapeutic Effects of Curcumin Nanoparticles on Monosodium Glutamate Induced Cardiotoxicity in Male Albino Rats

“…It is frequently utilized as a seasoning, stabilizing, and flavoring agent to increase the deliciousness of food products (Hajihasani et al, 2020;Banerjee et al, 2021a). It has been found naturally in tiny amounts in many types of food, including vegetables, meats, cheeses, and seafood (Gottardo et al, 2022;AlThobaiti, 2023); currently, MSG has been added to processed food products, canned vegetables, soups, and dietary supplements (Celestino et al, 2021;Xu et al, 2022). It is used frequently by Japanese and Chinese people (Acar, 2021).…”

Protocatechuic acid abrogates oxidative insults, inflammation, and apoptosis in liver and kidney associated with monosodium glutamate intoxication in rats

“…It elicits the "umami" taste experience that is recognized in high glutamate foods as meat, sh, cheese, and some vegetables (del Carmen Contini et al 2017). Currently, MSG can be added to soups, processed meats, dietary supplements, and canned vegetables (Celestino et al 2021). Despite of being reported as safe for human according to the last FDA reports, using of MSG as a food additive is still disputed (Shukry et al 2020).…”

Diet Significantly Influences the Immunopathology and Severity of Kidney Injury in Male C57Bl/6J Mice in a Model Dependent Manner

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