2006
DOI: 10.1073/pnas.0608565103
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Differential effects of spermatogenesis and fertility in mice lacking androgen receptor in individual testis cells

Abstract: Using a Cre-Lox conditional knockout strategy, we generated a germ cell-specific androgen receptor (AR) knockout mouse (G-AR ؊/y ) with normal spermatogenesis. Sperm count and motility in epididymis from AR ؊/y mice are similar to that of WT (G-AR ؉/y ) mice. Furthermore, fertility tests show there was no difference in fertility, and almost 100% of female pups sired by G-AR ؊/y males younger than 15 weeks carried the deleted AR allele, suggesting the efficient AR knockout occurred in germ cells during meiosis.… Show more

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Cited by 176 publications
(144 citation statements)
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“…It is known that androgens and their cognate receptors are critical in determining the male phenotype and their roles in spermatogenesis have been widely investigated (Ghosh et al, 1991;O'shaughnessy et al, 2002;Yeh et al, 2002;Tsai et al, 2006;Wang et al, 2009). On the other hand, there is little information concerning the influence of androgen/AR signaling on germ cell differentiation during the fetal and neonatal periods.…”
Section: Discussionmentioning
confidence: 99%
“…It is known that androgens and their cognate receptors are critical in determining the male phenotype and their roles in spermatogenesis have been widely investigated (Ghosh et al, 1991;O'shaughnessy et al, 2002;Yeh et al, 2002;Tsai et al, 2006;Wang et al, 2009). On the other hand, there is little information concerning the influence of androgen/AR signaling on germ cell differentiation during the fetal and neonatal periods.…”
Section: Discussionmentioning
confidence: 99%
“…[23][24][25][26] In contrast, androgen receptors on germ cells and myoid cells appears to be less important in spermatogenesis as knock out models in these situations, do not impair spermatogenesis in a major way. 23,27 Compounds that are cell specific and influence Sertoli and Leydig cell androgen receptors could potentially be an excellent site of future male contraceptive thoughts. As described earlier, complete blockage of the androgen receptor with flutamide suppresses spermatogenesis.…”
Section: Review Of Hypothalamic-pituitarygonadal Axis and Spermatogenmentioning
confidence: 99%
“…Furthermore, expression of the AR in germ cells is apparently not required for germ cell development. Germ cells in which the AR is defective develop normally when they are supported by AR-positive Sertoli cells [65,66] and mice with a germ cell specific AR knockout display normal fertility [67]. The only possibility that cannot be excluded is that androgens might affect germ cells via one of the mentioned alternative pathways that do not involve the AR.…”
Section: Identification Of the Sertoli Cell As The Main Target For Anmentioning
confidence: 99%