Differential effects of the serotonin1A agonist, 8-OH-DPAT, on masculine and feminine sexual behavior of the ferret

Paredes, Raúl G.; Kica, E.; Baum, Michael J.

doi:10.1007/bf02244989

Cited by 13 publications

(4 citation statements)

References 27 publications

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“…(1987) found an inhibitory effect of 8‐OH‐DPAT treatment in male sexual behaviour of albino mice (NMRI strain). An inhibitory role for 5‐HT 1A receptors in the control of masculine sexual behaviour has also been described for other species such as the rabbit (Paredes et al ., 2000) and the ferret (Paredes et al ., 1994). Thus, it appears that in mice both 5‐HT 1A and 5‐HT 1B receptors are involved in the inhibitory actions of serotonin on male copulatory behaviour.…”

Section: Discussionmentioning

confidence: 99%

Participation of 5‐HT_1B receptors in the inhibitory actions of serotonin on masculine sexual behaviour of mice: pharmacological analysis in 5‐HT_1B receptor knockout mice

Rodrı́guez–Manzo

López‐Rubalcava

Hen

et al. 2002

British J Pharmacology

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1 The role of the 5-Hydroxytryptamine(1B) (5-HT(1B)) receptor subtype in masculine sexual behaviour in mice was analysed in both 5-HT(1B) receptor knockout (KO(1B)) and wild-type (WT) animals. 2 Comparison of male copulatory behaviour of WT and KO(1B) strains revealed that KO(1B) mice become interested earlier in sexual behaviour, but require more stimulation to achieve ejaculation than its corresponding WT strain. 3 The pharmacological manipulation of male sexual activity in the WT strain showed that the serotonin precursor 5-Hydroxytryptophan (5-HTP), the 5-HT(1B) agonist (1-(m-trifluoromethylphenyl) piperazine (TFMPP) and the 5-Hydroxytryptamine(1A) (5-HT(1A)) receptor agonist 8-hydroxy-2-di-n-propylamino-tetralin (8-OH-DPAT) all inhibited male copulatory behaviour in mice. 4 In KO(1B) mice, TFMPP lacked an effect, 5-HTP exerted a mild inhibitory effect while 8-OH-DPAT provoked only a tendency towards a reduction in the percentage of animals that achieved ejaculation. In general, KO(1B) mice were less sensitive to the inhibitory actions of 5-HTP and 8-OH-DPAT than the WT strain. 5 Based on these results, we can suggest that serotonin plays a general inhibitory role in the sexual behaviour of male mice and that both 5-HT(1B) and 5-HT(1A) receptor subtypes participate in the inhibitory actions of this neurotransmitter. 6 The absence of the 5-HT(1B) receptor subtype affected both components of mouse masculine sexual behaviour, motivation and execution, further confirming the involvement of this receptor subtype in the control of this behaviour. In addition, the diminished sensitivity to serotonergic stimulation exhibited by KO(1B) mice suggests the occurrence of compensatory changes as a consequence of the absence of the 5-HT(1B) receptor subtype.

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Section: Discussionmentioning

confidence: 99%

Participation of 5‐HT_1B receptors in the inhibitory actions of serotonin on masculine sexual behaviour of mice: pharmacological analysis in 5‐HT_1B receptor knockout mice

Rodrı́guez–Manzo

López‐Rubalcava

Hen

et al. 2002

British J Pharmacology

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“…For example, the rabbit shows reduced but not absent lordosis after ovariectomy and does not show the stimulatory effect of progesterone (Beyer et al, 2007). In another reflex ovulator, the ferret, the serotonin receptor 5-HT1A agonist 8-hydroxy-2-(din-propylamino)tetralin (8-OH-DPAT) facilitates lordosis in EB primed ovariectomized females in contrast to the inhibition seen in the female rat (Paredes et al, 1994). Over the last two decades, the use of conditioning and preference paradigms in rodents has tested facets of appetitive sexual behaviour that have human equivalents (Pfaus et al, 2003).…”

Section: Animal Models Of Sex Behavior Aggression and Social Cognitionmentioning

confidence: 99%

Estrogenic regulation of social behavior and sexually dimorphic brain formation

Ogawa

Tsukahara

Choleris

et al. 2020

Neuroscience & Biobehavioral Reviews

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“…The effects of 5-HT 1A receptor agonists on the ejaculatory threshold are not universal. Systemic injection of 8-OH-DPAT inhibits ejaculation in mice (Rodriguez-Manzo et al, 2002), rabbits (Paredes et al, 2000), dogs (Yonezawa et al, 2004) and ferrets (Paredes et al, 1994), and either lowers or elevates the ejaculatory threshold in rhesus monkeys, depending on dose (Pomerantz et al, 1993b). Since 5-HT 1A autoreceptors probably have the same location and function in different mammalian species (Price et al, 1996), a difference in distribution of postsynaptic 5-HT 1A receptors in brain and spinal cord areas might explain this 8-OH-DPAT induced elevation of the ejaculatory threshold.…”

Section: -Ht 1a Receptorsmentioning

confidence: 99%

Serotonin and the neurobiology of the ejaculatory threshold

Jong

Veening

Waldinger

et al. 2006

Neuroscience & Biobehavioral Reviews

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Disorders of the ejaculatory threshold, such as lifelong premature ejaculation, are fairly common in humans and can have a great impact on the quality of life. Research in humans and rats have indicated that increased serotonin levels in the central nervous system elevate the ejaculatory threshold, probably via 5-HT(1B) and 5-HT(2C) receptors, whereas depletion of serotonin decreases the ejaculatory threshold. 5-HT(1A) receptor activation strongly lowers the ejaculatory threshold, probably mediated by both the reduction of serotonin levels via presynaptic 5-HT(1A) receptors and yet unknown effects of postsynaptic 5-HT(1A) receptors. The present review attempts to integrate psychopharmacological data on serotonergic control over ejaculation with the knowledge of the neuroanatomical substrate of ejaculation, indicating the importance of the lumbosacral spinal cord, the nucleus paragigantocellularis, the lateral hypothalamic area and several other supraspinal areas. In addition, the gaps in our understanding of the role of serotonin in the ejaculatory threshold are discussed. Filling in those gaps might help to design specific drugs that alter the ejaculatory threshold, thereby alleviating ejaculatory disorders.

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Differential effects of the serotonin1A agonist, 8-OH-DPAT, on masculine and feminine sexual behavior of the ferret

Cited by 13 publications

References 27 publications

Participation of 5‐HT_1B receptors in the inhibitory actions of serotonin on masculine sexual behaviour of mice: pharmacological analysis in 5‐HT_1B receptor knockout mice

Participation of 5‐HT_1B receptors in the inhibitory actions of serotonin on masculine sexual behaviour of mice: pharmacological analysis in 5‐HT_1B receptor knockout mice

Estrogenic regulation of social behavior and sexually dimorphic brain formation

Serotonin and the neurobiology of the ejaculatory threshold

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Differential effects of the serotonin1A agonist, 8-OH-DPAT, on masculine and feminine sexual behavior of the ferret

Cited by 13 publications

References 27 publications

Participation of 5‐HT1B receptors in the inhibitory actions of serotonin on masculine sexual behaviour of mice: pharmacological analysis in 5‐HT1B receptor knockout mice

Participation of 5‐HT1B receptors in the inhibitory actions of serotonin on masculine sexual behaviour of mice: pharmacological analysis in 5‐HT1B receptor knockout mice

Estrogenic regulation of social behavior and sexually dimorphic brain formation

Serotonin and the neurobiology of the ejaculatory threshold

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Product

Resources

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Participation of 5‐HT_1B receptors in the inhibitory actions of serotonin on masculine sexual behaviour of mice: pharmacological analysis in 5‐HT_1B receptor knockout mice

Participation of 5‐HT_1B receptors in the inhibitory actions of serotonin on masculine sexual behaviour of mice: pharmacological analysis in 5‐HT_1B receptor knockout mice