Differential effects of two chemotherapeutic agents, streptozotocin and chlorozotocin, on the mammalian cell cycle

Tobey, Robert A.; Oka, Melvin S.; Crissman, Harry A.

doi:10.1016/0014-2964(75)90075-4

Cited by 13 publications

(6 citation statements)

References 11 publications

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“…Alternatively, this could indicate a cell cycle block during the late S or G 2 phase of the cell cycle, which prevents cells from progressing through mitosis and reentering the G 1 phase, producing a reduction in G 1 cells when the cohort moves through the S phase. Similar events have been demonstrated following treatment with a wide range of apoptosis‐inducing agents [38–42]. Further evidence for the G 1 and S phase selectivity of ditelluride and telluranthrene is shown in Figures 4 and 5, which indicate that when apoptotic cells become apparent, the G 1 and S phases of the cell cycle are reduced, implying that cells within these two phases are preferentially being induced to enter apoptosis.…”

Section: Discussionsupporting

confidence: 71%

“…Cells present within the S phase or those entering the S phase from the G 1 phase are induced to undergo apoptotic cell death, and no repopulation of the G 1 phase of the cell cycle occurs because of the block in the G 2 phase. Similar dose‐dependent induction of apoptosis in conjunction with a cell cycle block has been demonstrated for numerous, effective chemotherapeutic agents [39,41,42].…”

Section: Discussionsupporting

confidence: 53%

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Bacterial cytotoxicity and induction of apoptosis in promyelocytic (Line HL‐60) cells by novel organotellurium compounds

Sailer

Prow

Dickerson

et al. 1999

Enviro Toxic and Chemistry

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Abstract-The increasing importance of tellurium in organic synthesis, in industrial applications, and as a possible component in pesticides means that its introduction into the environment will probably increase in the future. A knowledge of the relative toxicity and the mode of toxic action of tellurium-containing chemicals is therefore important. The work presented here, using growth-rate inhibition effects on Pseudomonas fluorescens of two model compounds, telluranthrene and tetrachlorodiphenyl ditelluride, suggests that these compounds are at least as toxic as the relatively well-known selenium oxyanions, selenate and selenite. Experiments with human promyelocytic (line HL-60) cells indicate that both the above organotellurium compounds induce a form of cell death called apoptosis, or programmed cell death. The induction of apoptosis occurred in both a time-and dose-dependent manner, as assayed by three different analytical methods: fluorescence microscopy, flow cytometry, and gel electrophoresis. The results indicate that organotellurium compounds may find applicability in the fields of chemoprevention and cancer therapy, similar to organoselenium compounds.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionsupporting

confidence: 53%

Bacterial cytotoxicity and induction of apoptosis in promyelocytic (Line HL‐60) cells by novel organotellurium compounds

Sailer

Prow

Dickerson

et al. 1999

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

show abstract

“…Alternatively, this could indicate a cell cycle block during the late S or G 2 phase of the cell cycle, which prevents cells from progressing through mitosis and reentering the G 1 phase, producing a reduction in G 1 cells when the cohort moves through the S phase. Similar events have been demonstrated following treatment with a wide range of apoptosis-inducing agents [38][39][40][41][42]. Further evidence for the G 1 and S phase selectivity of ditelluride and telluranthrene is shown in Figures 4 and 5, which indicate that when apoptotic cells become apparent, the G 1 and S phases of the cell cycle are reduced, implying that cells within these two phases are preferentially being induced to enter apoptosis.…”

Section: Discussionsupporting

confidence: 73%

“…Cells present within the S phase or those entering the S phase from the G 1 phase are induced to undergo apoptotic cell death, and no repopulation of the G 1 phase of the cell cycle occurs because of the block in the G 2 phase. Similar dose-dependent induction of apoptosis in conjunction with a cell cycle block has been demonstrated for numerous, effective chemotherapeutic agents [39,41,42].…”

Section: Discussionsupporting

confidence: 56%

Bacterial Cytotoxicity and Induction of Apoptosis in Promyelocytic (Line Hl-60) Cells by Novel Organotellurium Compounds

Sailer

Prow

Dickerson

et al. 1999

Environ Toxicol Chem

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The increasing importance of tellurium in organic synthesis, in industrial applications, and as a possible component in pesticides means that its introduction into the environment will probably increase in the future. A knowledge of the relative toxicity and the mode of toxic action of tellurium-containing chemicals is therefore important. The work presented here, using growth-rate inhibition effects on Pseudomonas fluorescens of two model compounds, telluranthrene and tetrachlorodiphenyl ditelluride, suggests that these compounds are at least as toxic as the relatively well-known selenium oxyanions, selenate and selenite. Experiments with human promyelocytic (line HL-60) cells indicate that both the above organotellurium compounds induce a form of cell death called apoptosis, or programmed cell death. The induction of apoptosis occurred in both a time-and dose-dependent manner, as assayed by three different analytical methods: fluorescence microscopy, flow cytometry, and gel electrophoresis. The results indicate that organotellurium compounds may find applicability in the fields of chemoprevention and cancer therapy, similar to organoselenium compounds.

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“…However, in the course of recent years, evidence has been collected that, in some situations, the non-proliferating cells may reveal an even greater sensitivity to drugs than proliferating cells Humphrey, 1973, 1975;Twentyman and Bleehen, 1973;Hahn, Gordon and Kurkjian, 1974;Sutherland, 1974;Tobey, Oka and Crissman, 1975; see also Marsh, 1976, for review). Although some of the results appear to be conflicting, there is no doubt at present that, at least under certain conditions, the non-proliferating cells may be severely damaged by concentrations of drugs less toxic to the proliferating cells.…”

mentioning

confidence: 99%

Responses of proliferating and non-proliferating Chinese hamster cells to cytotoxic agents

Epifanova¹,

Smolenskaya²,

Polunovsky³

1978

Br J Cancer

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Summary.-The effects of various cytotoxic chemicals, as measured by viable cell counts, colony-forming ability and proliferative capacity, have been studied using Chinese hamster cells in exponential and plateau (stationary) phases of growth. The proliferating cells were altogether more sensitive to the action of the drugs than nonproliferating cells. However, imuran (azathioprine) a purine antimetabolite, was more effective against the plateau-phase cells. The observed response of cells to imuran could be detected at a wide range of concentrations (1-100 ,ug/ml). These findings are discussed in view of the possible ability of imuran to interfere with active metabolic processes in non-proliferating cells.

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Differential effects of two chemotherapeutic agents, streptozotocin and chlorozotocin, on the mammalian cell cycle

Cited by 13 publications

References 11 publications

Bacterial cytotoxicity and induction of apoptosis in promyelocytic (Line HL‐60) cells by novel organotellurium compounds

Bacterial cytotoxicity and induction of apoptosis in promyelocytic (Line HL‐60) cells by novel organotellurium compounds

Bacterial Cytotoxicity and Induction of Apoptosis in Promyelocytic (Line Hl-60) Cells by Novel Organotellurium Compounds

Responses of proliferating and non-proliferating Chinese hamster cells to cytotoxic agents

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