Differential effects of various fish proteins in altering body weight, adiposity, inflammatory status, and insulin sensitivity in high-fat–fed rats

Pilon, Geneviève; Ruzzin, Jérôme; Rioux, Laurie‐Eve; Lavigne, Charles; White, Phillip J.; Frøyland, Livar; Jacques, Hélène; Bryl, Piotr; Beaulieu, Lucie; Marette, André

doi:10.1016/j.metabol.2010.12.005

Cited by 97 publications

(69 citation statements)

References 44 publications

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“…The reduction in fed-state plasma insulin and glucose concentrations, as well as the reduced hepatic Pck-1 expression in the SPH-fed rats, might indicate that these animals were more insulin-sensitive, relative to those fed casein. This notion is in agreement with a recent report in which rats fed a high fat SPH diet had increased whole body insulin sensitivity determined by the hyperinsulinemiceuglycemic clamp technique (68). In this study, pharmacological removal of BAs attenuated the reduction in nonfasted blood glucose (Fig.…”

Section: Nutritional Regulation Of Endogenous Ba Metabolism Modulatessupporting

confidence: 94%

Nutritional Regulation of Bile Acid Metabolism Is Associated with Improved Pathological Characteristics of the Metabolic Syndrome

Liaset¹,

Qin

Jørgensen

et al. 2011

Journal of Biological Chemistry

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Bile acids (BAs) are powerful regulators of metabolism, and mice treated orally with cholic acid are protected from dietinduced obesity, hepatic lipid accumulation, and increased plasma triacylglycerol (TAG) and glucose levels. Here, we show that plasma BA concentration in rats was elevated by exchanging the dietary protein source from casein to salmon protein hydrolysate (SPH). Importantly, the SPH-treated rats were resistant to diet-induced obesity. SPH-treated rats had reduced fed state plasma glucose and TAG levels and lower TAG in liver. The elevated plasma BA concentration was associated with induction of genes involved in energy metabolism and uncoupling, Dio2, Pgc-1␣, and Ucp1, in interscapular brown adipose tissue. Interestingly, the same transcriptional pattern was found in white adipose tissue depots of both abdominal and subcutaneous origin. Accordingly, rats fed SPH-based diet exhibited increased whole body energy expenditure and heat dissipation. In skeletal muscle, expressions of the peroxisome proliferatoractivated receptor ␤/␦ target genes (Cpt-1b, Angptl4, Adrp, and Ucp3) were induced. Pharmacological removal of BAs by inclusion of 0.5 weight % cholestyramine to the high fat SPH diet attenuated the reduction in abdominal obesity, the reduction in liver TAG, and the decrease in nonfasted plasma TAG and glucose levels. Induction of Ucp3 gene expression in muscle by SPH treatment was completely abolished by cholestyramine inclusion. Taken together, our data provide evidence that bile acid metabolism can be modulated by diet and that such modulation may prevent/ameliorate the characteristic features of the metabolic syndrome.

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Section: Nutritional Regulation Of Endogenous Ba Metabolism Modulatessupporting

confidence: 94%

Nutritional Regulation of Bile Acid Metabolism Is Associated with Improved Pathological Characteristics of the Metabolic Syndrome

Liaset¹,

Qin

Jørgensen

et al. 2011

Journal of Biological Chemistry

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“…Studies suggests that there are other components in fish such as fish proteins that may be beneficial to human health and affect risk factors leading to CVD, beyond n-3 fatty acids (15)(16)(17)(18) . This is supported by results from animal studies showing that fish proteins may have a lowering effect on TAG and cholesterol as well as improve glucose tolerance (19)(20)(21)(22)(23)(24)(25)(26) . In line with this, we have recently shown that supplementation with cod protein as tablets reduced fasting glucose and LDL-cholesterol as well as postprandial glucose concentrations in healthy, overweight adults (17) .…”

mentioning

confidence: 73%

“…There is controversy about the glucose-regulating effects of fatty fish or fish oil (9)(10)(11)31,35,48) ; however, studies in rats that are obese and/or fed high-fat or high-carbohydrate diets suggest that intake of fish proteins may improve glucose tolerance (21)(22)(23)(24)26) . Clinical studies also suggest that fish proteins may improve glucose regulation in overweight/obese participants (17)(18) .…”

Section: Discussionmentioning

confidence: 99%

High intake of fatty fish, but not of lean fish, affects serum concentrations of TAG and HDL-cholesterol in healthy, normal-weight adults: a randomised trial

et al. 2016

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The aim of the present study was to examine whether high intake of lean or fatty fish (cod and farmed salmon, respectively) by healthy, normal-weight adults would affect risk factors of type 2 diabetes and CVD when compared with lean meat (chicken). More knowledge is needed concerning the potential health effects of high fish intake (>300 g/week) in normal-weight adults. In this randomised clinical trial, thirty-eight young, healthy, normal-weight participants consumed 750 g/week of lean or fatty fish or lean meat (as control) for 4 weeks at dinner according to provided recipes to ensure similar ways of preparations and choices of side dishes between the groups. Energy and macronutrient intakes at baseline and end point were similar in all groups, and there were no changes in energy and macronutrient intakes within any of the groups during the course of the study. High intake of fatty fish, but not lean fish, significantly reduced TAG and increased HDL-cholesterol concentrations in fasting serum when compared with lean meat intake. When compared with lean fish intake, fatty fish intake increased serum HDL-cholesterol. No differences were observed between lean fish, fatty fish and lean meat groups regarding fasting and postprandial glucose regulation. These findings suggest that high intake of fatty fish, but not of lean fish, could beneficially affect serum concentrations of TAG and HDL-cholesterol, which are CVD risk factors, in healthy, normal-weight adults, when compared with high intake of lean meat.

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“…Fish is a food of high nutritional value, characterized by presenting components necessary for the human organism, such as mineral salts, high biological value proteins and fatty acids, principally the polyunsaturated ones of the omega 3 and omega 6 families (Bonacina & Queiroz, 2007;Pilon et al, 2011;Sampels, 2015). The ingestion of fish has been related to the prevention of heart and brain problems (Nestel et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Acceptance of fish hamburgers in school meals in the Southwest Region of Paraná, Brazil

et al. 2017

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The regular consumption of fish provides health gains for people, and its introduction in school meals is an important strategy to insert the habit of consuming this food by a population. Thus the objective of this study was to verify the acceptance of fish, presented in the form of hamburger, by children in municipal primary schools in the town of Pato Branco, Brazil, in which the school cooks had been trained to produce fish hamburgers. Acceptance was evaluated using a hedonic scale with 5 facial classifications (1 = disliked extremely to 5 = liked extremely). Students of both genders from 5 to 10 years of age (n = 142) were served the hamburgers for their midday meal, representing the protein portion of the meal. The results were analyzed by logistic regression. No effect of age or gender was observed between the children in the acceptance of the hamburgers, but the interaction between age and gender was significant. The cluster analysis was applied to distinguish this interaction using two-way joining to present the results, which showed the effect between specific age and gender situations. The acceptance index was 87% showing the potential for the consumption of this food by children.

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Differential effects of various fish proteins in altering body weight, adiposity, inflammatory status, and insulin sensitivity in high-fat–fed rats

Cited by 97 publications

References 44 publications

Nutritional Regulation of Bile Acid Metabolism Is Associated with Improved Pathological Characteristics of the Metabolic Syndrome

Nutritional Regulation of Bile Acid Metabolism Is Associated with Improved Pathological Characteristics of the Metabolic Syndrome

High intake of fatty fish, but not of lean fish, affects serum concentrations of TAG and HDL-cholesterol in healthy, normal-weight adults: a randomised trial

Acceptance of fish hamburgers in school meals in the Southwest Region of Paraná, Brazil

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