Differential efferent projections of GABAergic neurons in the basolateral and central nucleus of amygdala in mice

Liu, Jing; Hu, Tao; Zhang, Mengqi; Xu, Chunmei; Yuan, Mao-Yun; Li, Ruixi

doi:10.1016/j.neulet.2020.135621

Cited by 34 publications

(22 citation statements)

References 44 publications

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“…The lateral substantia nigra (SNL) is another brain region found to provide substantial input to LPB-PVT neurons. This group of cells is of special interest because it receives afferent input from the BSTDL/CeL (Steinberg et al 2020; Gonzales and Chesselet 1990; Vankova et al 1992; Liu et al 2021b) and a projection from the CeL to the SNL has been shown to modulate both appetitive and aversive learning (Steinberg et al 2020). Furthermore, the SNL and LPB are reciprocally connected (Tokita et al 2009; Huang et al 2021a; Vankova et al 1992) forming potentially an interconnected network of neurons involving the PB, PVT, SNL and BSTDL/CeL.…”

Section: Discussionmentioning

confidence: 99%

Convergence of monosynaptic inputs from neurons in the brainstem and forebrain on parabrachial neurons that project to the paraventricular nucleus of the thalamus

Kirouac

2022

Preprint

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The paraventricular nucleus of the thalamus (PVT) projects to areas of the forebrain involved in behavior. Homeostatic challenges and salient cues activate the PVT and evidence shows that the PVT regulates appetitive and aversive responses. The brainstem is a source of afferents to the PVT and the present study was done to determine if the lateral parabrachial nucleus (LPB) is a relay for inputs to the PVT. Retrograde tracing experiments with cholera toxin B (CTB) demonstrate that the LPB contains more PVT projecting neurons than other regions of the brainstem including the catecholamine cell groups. The hypothesis that the LPB is a relay for brainstem signals to the PVT was assessed using an intersectional monosynaptic rabies tracing approach. Sources of inputs included the reticular formation, periaqueductal gray (PAG), nucleus cuneiformis, superior and inferior colliculi, and the LPB. Distinctive clusters of input cells to LPB-PVT projecting neurons were also found in the dorsolateral bed nucleus of the stria terminalis (BSTDL) and the lateral central nucleus of the amygdala (CeL). Anterograde viral tracing demonstrates that LPB-PVT neurons densely innervate all of the PVT in addition to providing collateral innervation to the preoptic area, lateral hypothalamus, zona incerta and PAG but not the BSTDL and CeL. The paper discusses the anatomical evidence that suggests that the PVT is part of a network of interconnected neurons involved in arousal, homeostasis, and the regulation of behavioral states with forebrain regions potentially providing descending modulation or gating of signals relayed from the LPB to the PVT.

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Section: Discussionmentioning

confidence: 99%

Convergence of monosynaptic inputs from neurons in the brainstem and forebrain on parabrachial neurons that project to the paraventricular nucleus of the thalamus

Kirouac

2022

Preprint

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show abstract

“…The lateral substantia nigra (SNL) is another brain region found to be a distinct source of input to LPB-PVT neurons. This group of cells is of special interest because it receives afferent input from the BSTDL/CeL (Steinberg et al 2020 ; Gonzales and Chesselet 1990 ; Vankova et al 1992 ; Liu et al 2021b ) and a projection from the CeL to the SNL has been shown to modulate both appetitive and aversive learning (Steinberg et al 2020 ). Furthermore, the SNL and LPB are reciprocally connected (Tokita et al 2009 ; Huang et al 2021a ; Vankova et al 1992 ) forming potentially an interconnected network of neurons involving the PB, PVT, SNL and BSTDL/CeL.…”

Section: Discussionmentioning

confidence: 99%

Convergence of monosynaptic inputs from neurons in the brainstem and forebrain on parabrachial neurons that project to the paraventricular nucleus of the thalamus

Kirouac

2022

Brain Struct Funct

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The paraventricular nucleus of the thalamus (PVT) projects to areas of the forebrain involved in regulating behavior. Homeostatic challenges and salient cues activate the PVT and evidence shows that the PVT regulates appetitive and aversive responses. The brainstem is a source of afferents to the PVT and the present study was done to determine if the lateral parabrachial nucleus (LPB) is a relay for inputs to the PVT. Retrograde tracing experiments with cholera toxin B (CTB) demonstrate that the LPB contains more PVT projecting neurons than other regions of the brainstem including the catecholamine cell groups. The hypothesis that the LPB is a relay for signals to the PVT was assessed using an intersectional monosynaptic rabies tracing approach. Sources of inputs to LPB included the reticular formation; periaqueductal gray (PAG); nucleus cuneiformis; and superior and inferior colliculi. Distinctive clusters of input cells to LPB-PVT projecting neurons were also found in the dorsolateral bed nucleus of the stria terminalis (BSTDL) and the lateral central nucleus of the amygdala (CeL). Anterograde viral tracing demonstrates that LPB-PVT neurons densely innervate all regions of the PVT in addition to providing collateral innervation to the preoptic area, lateral hypothalamus, zona incerta and PAG but not the BSTDL and CeL. The paper discusses the anatomical evidence that suggests that the PVT is part of a network of interconnected neurons involved in arousal, homeostasis, and the regulation of behavioral states with forebrain regions potentially providing descending modulation or gating of signals relayed from the LPB to the PVT.

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“…However, we cannot exclude the possibility that involvement of LH GABAergic neurotransmission in BNST CB 1 receptor control of tachycardia to restraint stress is mediated by recruitment of intermediate brain regions. In fact, previous studies identified LH-projecting GABAergic neurons in brain regions that receive BNST inputs 49 – 52 and are involved in control of stress-evoked cardiovascular responses 53 – 55 , such as amygdala and lateral preoptic area. Therefore, further studies are necessary to directly assess if control of cardiovascular responses to stress by BNST CB 1 receptors are mediated by direct or indirect connections with the LH.…”

Section: Discussionmentioning

confidence: 99%

Lateral hypothalamus involvement in control of stress response by bed nucleus of the stria terminalis endocannabinoid neurotransmission in male rats

Gomes‐de‐Souza

Costa-Ferreira

Mendonça

et al. 2021

Sci Rep

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The endocannabinoid neurotransmission acting via local CB1 receptor in the bed nucleus of the stria terminalis (BNST) has been implicated in behavioral and physiological responses to emotional stress. However, the neural network related to this control is poorly understood. In this sense, the lateral hypothalamus (LH) is involved in stress responses, and BNST GABAergic neurons densely innervate this hypothalamic nucleus. However, a role of BNST projections to the LH in physiological responses to stress is unknown. Therefore, using male rats, we investigated the role of LH GABAergic neurotransmission in the regulation of cardiovascular responses to stress by CB1 receptors within the BNST. We observed that microinjection of the selective CB1 receptor antagonist AM251 into the BNST decreased the number of Fos-immunoreactive cells within the LH of rats submitted to acute restraint stress. Treatment of the BNST with AM251 also enhanced restraint-evoked tachycardia. Nevertheless, arterial pressure increase and sympathetically-mediated cutaneous vasoconstriction to restraint was not affected by CB1 receptor antagonism within the BNST. The effect of AM251 in the BNST on restraint-evoked tachycardia was abolished in animals pretreated with the selective GABAA receptor antagonist SR95531 in the LH. These results indicate that regulation of cardiovascular responses to stress by CB1 receptors in the BNST is mediated by GABAergic neurotransmission in the LH. Present data also provide evidence of the BNST endocannabinoid neurotransmission as a mechanism involved in LH neuronal activation during stressful events.

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Differential efferent projections of GABAergic neurons in the basolateral and central nucleus of amygdala in mice

Cited by 34 publications

References 44 publications

Convergence of monosynaptic inputs from neurons in the brainstem and forebrain on parabrachial neurons that project to the paraventricular nucleus of the thalamus

Convergence of monosynaptic inputs from neurons in the brainstem and forebrain on parabrachial neurons that project to the paraventricular nucleus of the thalamus

Convergence of monosynaptic inputs from neurons in the brainstem and forebrain on parabrachial neurons that project to the paraventricular nucleus of the thalamus

Lateral hypothalamus involvement in control of stress response by bed nucleus of the stria terminalis endocannabinoid neurotransmission in male rats

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