Differential engagement of anterior cingulate cortex subdivisions for cognitive and emotional function

Mohanty, Aprajita; Engels, Anna S.; Herrington, John D.; Heller, Wendy; Ho, Moon Ho Ringo; Banich, Marie T.; Webb, Andrew; Warren, Stacie L.; Miller, Gregory A.

doi:10.1111/j.1469-8986.2007.00515.x

Cited by 262 publications

(226 citation statements)

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“…Eleven hours of IBMT can induce changes in fractional anisotropy in the anterior corona radiata associated with the ACC, a key node of self-regulation network (8,12,13,27,28). IBMT has been shown to improve the basal immune system as the amount of training increases from 3 to 11 h (25).…”

Section: Discussionmentioning

confidence: 99%

Short-term meditation induces white matter changes in the anterior cingulate

Tang

Geng

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

432

353

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The anterior cingulate cortex (ACC) is part of a network implicated in the development of self-regulation and whose connectivity changes dramatically in development. In previous studies we showed that 3 h of mental training, based on traditional Chinese medicine (integrative body-mind training, IBMT), increases ACC activity and improves self-regulation. However, it is not known whether changes in white matter connectivity can result from small amounts of mental training. We here report that 11 h of IBMT increases fractional anisotropy (FA), an index indicating the integrity and efficiency of white matter in the corona radiata, an important white-matter tract connecting the ACC to other structures. Thus IBMT could provide a means for improving self-regulation and perhaps reducing or preventing various mental disorders.anterior cingulate cortex | anterior corona radiata | integrative body-mind training | relaxation training | self-regulation P revious studies on effects of long-term training on white matter assessed by diffusion tensor imaging (DTI) have had mixed results. Musicians show positive relations between fractional anisotropy (FA) and training in widespread white-matter regions such as the pyramidal tract (1, 2); however, the opposite result of lower FA in musicians than in nonmusicians in this region of the brain was also reported (3, 4). One study has reported that longterm abacus training from an early age enhances the integrity in white-matter tracts related to motor and visuospatial processes (5). Working memory is an important capacity involved in the shortterm maintenance and manipulation of information. A recent study found months of working memory training increases FA associated with the white matter adjacent to the frontoparietal regions critical in working memory (6). Much of the research in training effects on white-matter plasticity have compared experts and novices without explicit training and when training has been used has generally required months to years to produce changes in FA.The anterior cingulate cortex (ACC) is part of a network implicated in monitoring and resolving conflict among competing response tendencies (7,8). During infant and child development this structure has been shown to change its connectivity (9, 10). These changes have been related to the increasing ability of children to regulate their own emotions and behavior (11).Deficits in activation of the ACC have been associated with attention deficit disorder, addiction, dementia, depression, schizophrenia, and other disorders (12-16). In addiction, hypoactivation of the ACC has been found to be critical to symptoms of craving (17). In tobacco addiction, a circuit involving the ACC and striatum has been shown to have lower than normal connectivity (15). Thus evidence related to increasing the activation and strengthening connectivity of the ACC may be useful as a treatment or prevention of addiction and other disorders.The anterior corona radiata has been identified as one important white-matter tract connecting the ...

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Section: Discussionmentioning

confidence: 99%

Short-term meditation induces white matter changes in the anterior cingulate

Tang

Geng

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

432

353

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“…A leading model of ACC function holds that the rostral ACC (including subgenual ACC) is preferentially engaged during emotional tasks and that the dACC is preferentially engaged during cognitive processing (Bush et al, 2000;Devinsky et al, 1995;Mohanty et al, 2007). Regarding the latter, several neuroimaging studies highlight the role of the dACC in directing (Weissman et al, 2005) and capturing (Corbetta et al, 1991;Pardo et al, 1990) attention, error detection (Fassbender et al, 2004), conflict monitoring (Botvinick et al, 2004), mental effort (Mulert et al, 2005) and many other cognitive functions.…”

Section: Introductionmentioning

confidence: 99%

“…More specifically, the dACC is activated when attention is directed to the feeling of sadness (Drevets and Raichle, 1998), when the unpleasantness of pain is amplified by post-hypnotic suggestion (Rainville et al, 1999), during the experience of social rejection (Eisenberger et al, 2003) and during awareness and monitoring of one's own emotional experiences (Hutcherson et al, 2005;Ochsner et al, 2002;Taylor et al, 2003). These observations suggest that the dACC participates in emotional as well as cognitive processing, and raise questions (Lane and McRae, 2004) about the validity of a dichotomy between cognitive (dACC) and affective (rostral ACC) divisions of the ACC (Bush et al, 2000;Mohanty et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Association between trait emotional awareness and dorsal anterior cingulate activity during emotion is arousal-dependent

et al. 2008

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The dorsal anterior cingulate cortex (dACC) is commonly thought to subserve primarily cognitive functions, but has been strongly implicated in the allocation of attention to emotional information. In a previous positron emission tomography (PET) study, we observed that women with higher emotional awareness as measured by the Levels of Emotional Awareness Scale (LEAS) showed greater changes in regional cerebral blood flow (rCBF) in dACC induced by emotional films and recall. In the current study, we tested whether these effects were due to the processing of any nonneutral stimulus, or were specific to conditions of high emotional arousal. Our results extend the previous finding by demonstrating a positive correlation between emotional awareness and dACC activity only in the context of viewing highly arousing pictures. No such relationship was observed when comparing pleasant or unpleasant pictures to neutral or to each other. We also observed that the relationship between LEAS and dACC activity was present in both sexes but stronger in women than men. These results reinforce the concept that greater trait awareness of one's own emotional experiences is associated with greater engagement of the dACC during emotional arousal, which we suggest may reflect greater attentional processing of emotional information.

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“…Among the 36 independent components, 13 were found to be artifacts or noises upon visual inspection. Thus, 23 components were identified as anatomically and functionally meaningful networks, which was in accordance with previously reported networks (Aboitiz, Ossandon, Zamorano, Palma, & Carrasco, 2014; Green, Kraemer, Fugelsang, Gray, & Dunbar, 2010; Kahnt, Chang, Park, Heinzle, & Haynes, 2012; Kotz, Cappa, von Cramon, & Friederici, 2002; Mohanty et al., 2007; Nekovarova, Fajnerova, Horacek, & Spaniel, 2014; Nocchi et al., 2012; Rosazza et al., 2014; Spreng, Sepulcre, Turner, Stevens, & Schacter, 2012; Turken & Dronkers, 2011; Uddin, Clare Kelly, Biswal, Xavier Castellanos, & Milham, 2009; Wu, Liu, Hallett, Zheng, & Chan, 2013). …”

Section: Methodsmentioning

confidence: 99%

Aberrant neural networks for the recognition memory of socially relevant information in patients with schizophrenia

Chun

Kim

et al. 2016

Brain and Behavior

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IntroductionPatients with schizophrenia exhibit several cognitive deficits, including memory impairment. Problems with recognition memory can hinder socially adaptive behavior. Previous investigations have suggested that altered activation of the frontotemporal area plays an important role in recognition memory impairment. However, the cerebral networks related to these deficits are not known. The aim of this study was to elucidate the brain networks required for recognizing socially relevant information in patients with schizophrenia performing an old–new recognition task.MethodsSixteen patients with schizophrenia and 16 controls participated in this study. First, the subjects performed the theme‐identification task during functional magnetic resonance imaging. In this task, pictures depicting social situations were presented with three words, and the subjects were asked to select the best theme word for each picture. The subjects then performed an old–new recognition task in which they were asked to discriminate whether the presented words were old or new. Task performance and neural responses in the old–new recognition task were compared between the subject groups. An independent component analysis of the functional connectivity was performed.ResultsThe patients with schizophrenia exhibited decreased discriminability and increased activation of the right superior temporal gyrus compared with the controls during correct responses. Furthermore, aberrant network activities were found in the frontopolar and language comprehension networks in the patients.ConclusionsThe functional connectivity analysis showed aberrant connectivity in the frontopolar and language comprehension networks in the patients with schizophrenia, and these aberrations possibly contribute to their low recognition performance and social dysfunction. These results suggest that the frontopolar and language comprehension networks are potential therapeutic targets in patients with schizophrenia.

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Differential engagement of anterior cingulate cortex subdivisions for cognitive and emotional function

Cited by 262 publications

References 55 publications

Short-term meditation induces white matter changes in the anterior cingulate

Short-term meditation induces white matter changes in the anterior cingulate

Association between trait emotional awareness and dorsal anterior cingulate activity during emotion is arousal-dependent

Aberrant neural networks for the recognition memory of socially relevant information in patients with schizophrenia

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