Differential enhancement of locomotor activity by dopamine agonists following chronic neuroleptic treatment: an animal model of tardive dyskinesia

Punding and dyskinesias

“…12, 2006 punding in PD to antipsychotic use, 11 also known to be capable of inducing forms of behavioral sensitization. 12 Although the pathophysiology of punding in Parkinson's disease has still to be clarified, its similarity with other drug-induced stereotypies suggests that it may be related to plastic changes in the ventral and dorsal striatal structures 13,14 including the nucleus accumbens 15 and linked to psychomotor stimulation and reward mechanisms. The pathophysiology of peak-dose dyskinesias is also poorly understood, but age, degree of striatal denervation, 16 and genetic influences on striatal neuroplasticity are all thought to be relevant.…”