Differential Evolution Model for Identification of Most Influenced Gene in Brest Cancer Data

Abstract

Microarray technology generates a large amount of data. Clustering is a popular technique for locating genes that are expressed in close proximity. It entails examining a fresh dataset to determine whether similar traits can be used to identify any hidden groupings. There are large-dimensional datasets accessible, such as those produced from gene expression investigations, RNA microarray studies, or RNA sequencing studies. As a consequence, cluster analysis and producing well-separated clusters become more challenging. Good cluster separation is desirable since it suggests that items are not being placed in the erroneous clusters. In this study, it was recommended that a Differential Evolution-based (DE) Model be used to interpret the analysis of Brest cancer gene expression. To begin, cluster the gene expression data to find the genes most likely to be impacted by the illness. The appropriate number of clusters must be found in order to locate the gene with the highest effect in the gene collection. We used a DE model on the Brest cancer datasets in this work. We identified the best number of clusters by using the most impacted gene in this dataset as a benchmark. We then experimented with different cluster sizes. We used the DE method to three distinct breast cancer datasets and compared it to the current K-Means and K-medoids models. The results of the experiments show that the proposed DE model outperforms existing models significantly.