Differential expression and molecular interactions of chromosome region maintenance 1 and calreticulin exportins in breast cancer cells

Cruz-Ramos, Eduardo; Sandoval-Hernández, Antonio; Tecalco-Cruz, Ángeles C.

doi:10.1016/j.jsbmb.2018.07.003

Cited by 16 publications

(12 citation statements)

References 43 publications

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“…These processes could be regarded as positive factor for tumor cell proliferation. All the conclusions above can be a supplemental demonstration of previous researches ( 26 - 37 ).…”

Section: Discussionsupporting

confidence: 74%

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SE translation mRNA overexpression: a potential prognostic predictor in breast cancer

Hao

Liu

et al. 2019

Transl. Cancer Res.

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Background: Patient SE translation (SET) belongs to histone chaperone nucleosome assembly protein family and has been confirmed that it is associated with carcinogenesis, tumor progression and patient outcome. In this study, we aim at assessing the prognostic value of SET mRNA, the function and pathway of SET and its related genes in breast cancer. Methods:The clinicopathological and prognostic significance of SET was assessed by the molecular taxonomy of breast cancer international consortium (METABRIC) database (n=1,904). Additionally, based on the data and network of SET and its related genes from cBioPortal website, their function in the progression of breast cancer was also explored.Results: SET mRNA overexpression was a significant predictor of a poor prognosis (P=0.0006). The two signaling pathways associated with SET were the facilitating function of condensin II on mitosis and the accelerated transportation of tumor cell mRNA towards the extranuclear position, and SET acted to suppress condensin II and stabilize mRNA. Conclusions:Owing to the regulation of chromosome condensation and stabilization of tumor cell mRNA, overexpression of SET is correlated with aggressive phenotypes and facilitates tumor proliferation and deterioration. SET may act as a valuable prognosis biomarker in breast cancer.

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“…These processes could be regarded as positive factor for tumor cell proliferation. All the conclusions above can be a supplemental demonstration of previous researches ( 26 - 37 ).…”

Section: Discussionsupporting

confidence: 74%

“…These processes could be regarded as positive factor for tumor cell proliferation. All the conclusions above can be a supplemental demonstration of previous researches (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37). Indeed, there are still some limitations in this study.…”

Section: Discussionsupporting

confidence: 57%

SE translation mRNA overexpression: a potential prognostic predictor in breast cancer

Hao

Liu

et al. 2019

Transl. Cancer Res.

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“…A reproduction-related QTL was found on this CALR. Eduardo et al [34] have shown that CRM-1 and CALR were upregulated in mammary tumors relative to normal mammary tissue. The mRNA and protein levels of CRM-1 and CALR were higher in breast cancer cells lacking ERα compared with those that express Erα.…”

Section: Discussionmentioning

confidence: 99%

Identification of Estrus in Sows Based on Salivary Proteomics

Song²,

Qi³

et al. 2022

Animals

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The estrus cycle of multiparous Large White sows was divided into three stages to solve the problems of heavy workload and low accuracy of the traditional estrus identification method in pig production. Saliva protein was extracted from the oral saliva of multiparous sows. Label-free quantitative proteomics was used to detect salivary proteome, and MaxQuant software was used for quality control. Results showed that 246 proteins were identified in the three stages, where 40 proteins were significantly different (p < 0.05). The total proteins identified were enriched by STEM software and the protein function was annotated by using the ClueGO plug-in in the Cytoscape software. The results were enriched to eight different trends. The annotated items were related to protein synthesis and processing and estrogen response. Gene ontology and the Kyoto Encyclopedia of Genes and Genomes enrichment analysis of differential proteins involved in the pathways and entries included oocyte meiosis, response to estradiol, and oogenesis. Further interaction analysis showed that an interaction occurred between P00355, F1SHL9, P28491, F1SDR7, F2Z558, F1RYY6, and F2Z5G3 proteins. The findings served as a basis for revealing the changes in salivary protein content in the sow estrus cycle and provided a reference for the development of an estrus identification kit/test strip in the next step.

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“…UQCRQ was identi ed as the signi cant protein in triple-negative breast cancer 32 . Eduardo Cruz-Ramos et al found the CALR levels were increased in breast cancer cells lacking estrogen receptor alpha (ERα), in comparison with those that express Erα 33 . G-protein-coupled receptors (GPCRs) and Regulators of G protein signaling (RGS) are key regulators that modulate a variety of human diseases including arthritis, bone, and heart diseases [34][35][36][37][38][39][40][41][42][43] .…”

Section: Discussionmentioning

confidence: 99%

Genomic analyses identify biological processes of miR-125 mediated breast cancer cells

Guo¹,

Zhang²,

Liu³

et al. 2021

Preprint

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miRNAs contain suppressive and oncogenic properties to regulate the progression of cancers. The expression of miR-125b expression is reported to be consistently low in breast cancers. However, the function and mechanism of miR-125b are not fully understood in breast cancers. In our study, our objective is to identify the DEGs and biological processes in the miR-125b mediated breast cancer cells by analyzing the RNA-seq data. The GSE123358 dataset was produced by the Illumina HiSeq 2000 (Homo sapiens). The KEGG and GO analyses showed the mitochondria and endoplasmic reticulum oxidative phosphorylation pathways are the main processes in miR-125b mediated breast cancer. Moreover, we identified ten interactive molecules including UQCRQ, CALR, HNRNPU, ATP5G1, NDUFB11, UQCRH, HSP90B1, TGOLN2, SAP18, and XPOT. Thus, our study may benefit the treatment of breast cancer by using miR-125b.

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Differential expression and molecular interactions of chromosome region maintenance 1 and calreticulin exportins in breast cancer cells

Cited by 16 publications

References 43 publications

SE translation mRNA overexpression: a potential prognostic predictor in breast cancer

SE translation mRNA overexpression: a potential prognostic predictor in breast cancer

Identification of Estrus in Sows Based on Salivary Proteomics

Genomic analyses identify biological processes of miR-125 mediated breast cancer cells

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