Differential expression of entactin-1/nidogen-1 and entactin-2/nidogen-2 in myogenic differentiation

Neu, Ricarda; Adams, Sherrill L.; Munz, Barbara

doi:10.1111/j.1432-0436.2006.00100.x

Cited by 16 publications

(9 citation statements)

References 51 publications

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“…Synaptic BL can be deposited by muscles fibers, motor nerve terminals or Schwann cells [ 4 , 5 , 39 ]. Both muscle and Schwann cells have been reported to express nidogen-2 [ 40 , 41 ]. To determine whether muscle cells can contribute nidogen-2 to the synaptic cleft, we used a muscle cell line, C2C12.…”

Section: Resultsmentioning

confidence: 99%

A synaptic nidogen: Developmental regulation and role of nidogen-2 at the neuromuscular junction

Fox

Smyth

et al. 2008

Neural Dev

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Background: The skeletal neuromuscular junction is a useful model for elucidating mechanisms that regulate synaptogenesis. Developmentally important intercellular interactions at the neuromuscular junction are mediated by the synaptic portion of a basal lamina that completely ensheaths each muscle fiber. Basal laminas in general are composed of four main types of glycosylated proteins: laminins, collagens IV, heparan sulfate proteoglycans and nidogens (entactins). The portion of the muscle fiber basal lamina that passes between the motor nerve terminal and postsynaptic membrane has been shown to bear distinct isoforms of the first three of these. For laminins and collagens IV, the proteins are deposited by the muscle; a synaptic proteoglycan, z-agrin, is deposited by the nerve. In each case, the synaptic isoform plays key roles in organizing the neuromuscular junction. Here, we analyze the fourth family, composed of nidogen-1 and -2.

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Section: Resultsmentioning

confidence: 99%

A synaptic nidogen: Developmental regulation and role of nidogen-2 at the neuromuscular junction

Fox

Smyth

et al. 2008

Neural Dev

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“…While this is correlative, it suggests that different ECM molecules may have opposing functions in the specification of particular cell fates. Entactin was shown to promote myogenic differentiation in vitro (Neu et al, 2006) though a function for fibronectin as a suppressor of myogenic fate has not been reported.…”

Section: Ecm In Differentiationmentioning

confidence: 99%

The extracellular matrix in development and morphogenesis: A dynamic view

Rozario

DeSimone

2010

Developmental Biology

1,199

927

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The extracellular matrix (ECM) is synthesized and secreted by embryonic cells beginning at the earliest stages of development. Our understanding of ECM composition, structure and function has grown considerably in the last several decades and this knowledge has revealed that the extracellular microenvironment is critically important for cell growth, survival, differentiation and morphogenesis. ECM and the cellular receptors that interact with it mediate both physical linkages with the cytoskeleton and the bidirectional flow of information between the extracellular and intracellular compartments. This review considers the range of cell and tissue functions attributed to ECM molecules and summarizes recent findings specific to key developmental processes. The importance of ECM as a dynamic repository for growth factors is highlighted along with more recent studies implicating the 3-dimensional organization and physical properties of the ECM as it relates to cell signaling and the regulation of morphogenetic cell behaviors. Embryonic cell and tissue generated forces and mechanical signals arising from ECM adhesion represent emerging areas of interest in this field.

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“…Additionally, these nidogens show a broad range of interacting partners including other BM proteins such as laminin, collagen IV, and perlecan [51, 53–55]. They are involved in various functions including the regulation of cell attachment [56], neutrophil chemotaxis [57], trophoblast outgrowth [58], angiogenesis [59], osteoblast, and myogenic differentiation [60, 61]. Vascular endothelial growth factors (VEGFs) constitute a family of six polypeptides (VEGF-A, -B, -C, -D, -E, and PlGF) that regulate blood and lymphatic vessel development [62].…”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of Glycogene Expression in Different Mouse Tissues Using RNA-Seq Data

Firoz

Malik

Singh

et al. 2014

International Journal of Genomics

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Glycogenes regulate a wide array of biological processes in the development of organisms as well as different diseases such as cancer, primary open-angle glaucoma, and renal dysfunction. The objective of this study was to explore the role of differentially expressed glycogenes (DEGGs) in three major tissues such as brain, muscle, and liver using mouse RNA-seq data, and we identified 579, 501, and 442 DEGGs for brain versus liver (BvL579), brain versus muscle (BvM501), and liver versus muscle (LvM442) groups. DAVID functional analysis suggested inflammatory response, glycosaminoglycan metabolic process, and protein maturation as the enriched biological processes in BvL579, BvM501, and LvM442, respectively. These DEGGs were then used to construct three interaction networks by using GeneMANIA, from which we detected potential hub genes such as PEMT and HPXN (BvL579), IGF2 and NID2 (BvM501), and STAT6 and FLT1 (LvM442), having the highest degree. Additionally, our community analysis results suggest that the significance of immune system related processes in liver, glycosphingolipid metabolic processes in the development of brain, and the processes such as cell proliferation, adhesion, and growth are important for muscle development. Further studies are required to confirm the role of predicted hub genes as well as the significance of biological processes.

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Differential expression of entactin-1/nidogen-1 and entactin-2/nidogen-2 in myogenic differentiation

Cited by 16 publications

References 51 publications

A synaptic nidogen: Developmental regulation and role of nidogen-2 at the neuromuscular junction

A synaptic nidogen: Developmental regulation and role of nidogen-2 at the neuromuscular junction

The extracellular matrix in development and morphogenesis: A dynamic view

Comparative Analysis of Glycogene Expression in Different Mouse Tissues Using RNA-Seq Data

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