Differential expression of IL-6/IL-6R and MAO-A regulates invasion/angiogenesis in breast cancer

Bharti, Rashmi; Dey, Goutam; Das, Anjan Kumar; Mandal, Mahitosh

doi:10.1038/s41416-018-0078-x

Cited by 46 publications

(38 citation statements)

References 32 publications

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“…In cell experiments, the use of CoCl 2 to simulate hypoxia and hypoxia incubators are both effective methods to induce hypoxia, and cells treated with 100 µM (28), 200 µM (29) or 300 µM (30) CoCl 2 are often used as controls. Therefore, 200 µM CoCl 2 was used in this experiment to simulate hypoxia, and this method could effectively induce hypoxia.…”

Section: Discussionmentioning

confidence: 99%

Tanshinone IIA reduces secretion of pro‑angiogenic factors and inhibits angiogenesis in human colorectal cancer

et al. 2020

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Tumor angiogenesis is an important factor which precipitates recurrence and metastasis of colorectal cancer (CRC). Angiogenesis is also a significant feature which accompanies invasion and metastasis of CRC. Tumor hypoxia activates hypoxia inducible factor (HIF), which promotes angiogenesis in CRC. HIF significantly promotes cell proliferation and angiogenesis in CRC, facilitating invasion and metastasis. Tanshinone IIA (Tan IIA) has been revealed to effectively inhibit angiogenesis in CRC, although the underlying mechanism remains to be determined. The aim of the present study was to determine the effects of HIF-1α on hypoxia induced angiogenesis in CRC cells, the effects of Tan IIA on the expression of pro-angiogenic factors in CRC cells, and on human umbilical vein endothelial cell (HUVEC) tube formation in normal and hypoxic conditions. The results of the present study revealed that Tan IIA not only decreased HIF-1α expression and inhibited the secretion level of vascular endothelial growth factor and basic fibroblast growth factor, but also efficiently decreased proliferation, tube formation and metastasis of HUVECs. The results highlight the potential of Tan IIA-mediated targeting of HIF-1α as a potential therapeutic option for treatment of patients with CRC.

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Section: Discussionmentioning

confidence: 99%

Tanshinone IIA reduces secretion of pro‑angiogenic factors and inhibits angiogenesis in human colorectal cancer

et al. 2020

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“…MAOA was also proved to be correlated with the worse prognosis of HER‐2 subtype breast cancer 27 . Further studies supported that upregulated MAOA promoted angiogenesis in breast cancer 28 and contributed to the transition from epithelial to mesenchymal in lung cancer 29 . Li et al discovered that MAOA was downregulated in cholangiocarcinoma (ICC) specimens through hypermethylation orinterleukin‐6 (IL‐6) signaling and that MAOA could serve as a prognostic biomarker for ICC patients 30 .…”

Section: Introductionmentioning

confidence: 99%

The clinical value and potential molecular mechanism of the downregulation of MAOA in hepatocellular carcinoma tissues

Pang

et al. 2020

Cancer Medicine

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Background Hepatocellular carcinoma (HCC) remains one of the most common cancers worldwide and tends to be detected at an advanced stage. More effective biomarkers for HCC screening and prognosis assessment are needed and the mechanisms of HCC require further exploration. The role of MAOA in HCC has not been intensively investigated. Methods In‐house tissue microarrays, genechips, and RNAsequencing datasets were integrated to explore the expression status and the clinical value of MAOA in HCC. Immunohistochemical staining was utilized to determine MAOA protein expression. Intersection genes of MAOA related co‐expressed genes and differentially expressed genes were obtained to perform functional enrichment analyses. In vivo experiment was conducted to study the impact of traditional Chinese medicine nitidine chloride (NC) on MAOA in HCC. Results MAOA was downregulated and possessed an excellent discriminatory capability in HCC patients. Decreased MAOA correlated with poor prognosis in HCC patients. Downregulated MAOA protein was relevant to an advanced TNM stage in HCC patients. Co‐expressed genes that positively related to MAOA were clustered in chemical carcinogenesis, where CYP2E1 was identified as the hub gene. In vivo experiment showed that nitidine chloride significantly upregulated MAOA in a nude mouse HCC model. Conclusions A decreased MAOA level is not only correlated with aggressive behaviors in males but also serves as a promising biomarker for the diagnosis and prognosis of HCC patients. Moreover, MAOA may play a role in AFB1 toxic transformation through its synergistic action with co‐expressed genes, especially CYP3A4. MAOA also serves as a potential therapy target of NC in HCC patients.

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“…A recent study highlighted the differential expression of IL-6/IL-6R and MAO-A in the regulation of invasion/angiogenesis in breast cancer. 19,20 In addition, this IL-6R regulation of MAO-A occurs through cellular MAP kinase and Akt pathways. 20 Other findings demonstrate that regulation of monoamine levels by MAO activity in β cells is pivotal for physiological insulin in type 2 diabetes.…”

Section: Regulatory Role Of Insulin In Breast Cancer In Patients Withmentioning

confidence: 99%

“…19,20 In addition, this IL-6R regulation of MAO-A occurs through cellular MAP kinase and Akt pathways. 20 Other findings demonstrate that regulation of monoamine levels by MAO activity in β cells is pivotal for physiological insulin in type 2 diabetes. 21 In contrast, MAO inhibitors are capable of both potentiating and inhibiting insulin release http://www.sajs.co.za…”

Section: Regulatory Role Of Insulin In Breast Cancer In Patients Withmentioning

confidence: 99%

“…19 Growing evidence suggests that IL-6 is also involved in cancer progression, metastasis, chemo-resistance and angiogenesis through the activation of IL-6R. 20 Monoamine oxidase (MAO) has two isoforms: MAO-A and MAO-B, which are generally present in the outer mitochondrial membrane. MAO-A levels are significantly lower in multiple invasive and metastatic cancer types including breast cancer.…”

Section: Regulatory Role Of Insulin In Breast Cancer In Patients Withmentioning

confidence: 99%

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Possible importance of Cannabis sativa L. in regulation of insulin and IL-6R/MAO-A in cancer cell progression and migration of breast cancer patients with diabetes

Bala

Matsabisa

2018

S. Afr. J. Sci.

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Differential expression of IL-6/IL-6R and MAO-A regulates invasion/angiogenesis in breast cancer

Abstract: Suppression of MAO-A by IL-6/IL-6R activation promotes tumour angiogenesis and invasion in hypoxic breast cancer environment.

Cited by 46 publications

References 32 publications

Tanshinone IIA reduces secretion of pro‑angiogenic factors and inhibits angiogenesis in human colorectal cancer

Tanshinone IIA reduces secretion of pro‑angiogenic factors and inhibits angiogenesis in human colorectal cancer

The clinical value and potential molecular mechanism of the downregulation of MAOA in hepatocellular carcinoma tissues

Possible importance of Cannabis sativa L. in regulation of insulin and IL-6R/MAO-A in cancer cell progression and migration of breast cancer patients with diabetes

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