Differential expression of microRNAs in plasma of patients with laryngeal squamous cell carcinoma: potential early-detection markers for laryngeal squamous cell carcinoma

Abstract

In conclusion, our study suggests that detecting these LSCC-specific miRNAs in plasma might serve as novel noninvasive biomarkers for LSCC.

MicroRNAs in spent blastocyst culture medium are derived from trophectoderm cells and can be explored for human embryo reproductive competence assessment

“…Bioinformatics analysis of these miRNAs showed several biologic pathways and cellular function regulated from them, including cell proliferation, cell communication, and cell signalling. Importantly, these two miRNAs have been already reported as circulating in human body fluids (44)(45)(46)(47)(48)(49)(50). Even if further data are needed to confirm these preliminary findings, this is the first report highlighting the potential role of miRNAs quantification from the easily collectable SBM as a new biomarker to be further explored for embryo selection.…”

MicroRNAs and head and neck cancer: Reviewing the first decade of research

“…A panel of 5 miRNAs (miR-331-3p, -603, -1303, -660-5p and -212-3p) was suggested to be specific for LSCC in a small study [153]. A study examining the serum of patients with oral carcinoma in-situ and OSCC found 15 miRNAs upregulated and 5 down regulated compared to normal controls.…”

“…Tumour [157] OSCC, OPSCC, LSCC, HSCC Plasma miR-21 qRT-PCR Ayaz et al [153] LSCC most commonly identified and always upregulated) [49,[60][61][62][63][64][65][66][67][68][69][70][71]. miR-21 upregulation has been significantly associated with poor prognosis in HNSCC patients [72,73].…”

MicroRNA-10a silencing reverses cisplatin resistance in the A549/cisplatin human lung cancer cell line via the transforming growth factor-β/Smad2/STAT3/STAT5 pathway

“…With the increase of studies focusing on this field of research, miRNAs have been confirmed to be involved in a variety of physiological and pathological activities, including cell proliferation, apoptosis, cell cycle regulation, tumor formation and inflammation (2). One previous study demonstrated that miRNA, including miR205, was closely associated with tumor development; in addition, the involvement of miRNAs in tumor formation can be classified into two categories according to their different effects: Cancer-promoting and -suppressing miRNAs (3,4). miRNA (miR)-10a novel microRNA, which was found to be closely associated with tumor growth, survival, invasion and metastasis.…”