Differential expression of S1P receptor subtypes in human bladder transitional cell carcinoma

Palangi, Alireza; Shakhssalim, Nasser; Parvin, Mahmoud; Bayat, Samira; Allameh, Abdolamir

doi:10.1007/s12094-019-02049-3

Cited by 7 publications

(4 citation statements)

References 26 publications

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“…However, the role of S1PR1 in cancer remains controversial. Correlation of S1PR1 with pathological grade in tumors suggests its potential as a prognostic tool for patients with bladder cancer as well as liver and gallbladder cancers [37,[51][52][53]. On the other hand, low S1PR1 expression is suggested to be linked to poor prognosis in breast and lung cancer [54,55].…”

Section: Discussionmentioning

confidence: 99%

Targeting S1PR1 May Result in Enhanced Migration of Cancer Cells in Bladder Carcinoma

Chen

Meng

et al. 2021

Cancers

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Clinical bladder tumor histological analysis shows that high expression of S1PR1 is associated with poor patient prognosis. However, there are no studies that describe the underlying mechanism. To investigate the relative distribution and actual function of S1PR1 in bladder tumors, we analyzed multiple clinical databases in combination with tumor purity and immune cell infiltration simulations, as well as databases of well-defined histological phenotypes of bladder cancer, and single-cell sequencing of adjacent normal tissues and bladder tumors, and further compared them with bladder cancer cell lines. The results showed that S1PR1 expression was generally higher in normal tissues than in bladder cancer tissues, and its distribution was mainly in endothelial cells or immune cells. The association between high S1PR1 expression and poor prognosis may be due to tumor invasion of adjacent normal tissues, where highly expressed S1PR1 may affect prognostic interpretation. The effect of S1PR1 itself on cancer cells was associated with cell adhesion, and in bladder cancer cells, S1PR1 expression was negatively correlated with cell motility. Moreover, the use of FTY-720 will cause an increased metastatic ability of bladder cancer cells. In conclusion, we suggest that the use of S1PR1-specific inhibition as a synergistic treatment requires more observation and consideration.

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Section: Discussionmentioning

confidence: 99%

Targeting S1PR1 May Result in Enhanced Migration of Cancer Cells in Bladder Carcinoma

Chen

Meng

et al. 2021

Cancers

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“…It has been reported that there were upregulation of S1PR1 , S1PR2 , and S1PR3 expressions in tumor tissues compared with normal margins in a subpopulation of Iranian BC patients. There were also correlations among S1PR1 overexpression, higher grades, and advanced stages (Palangi, Shakhssalim, Parvin, Bayat, & Allameh, 2019). S100 (OMIM: 617427) are calcium‐binding proteins involving in cell proliferation, apoptosis, and inflammation.…”

Section: Cell Signaling and Kinasesmentioning

confidence: 95%

Genetic and molecular biology of bladder cancer among Iranian patients

Mojarrad

Moghbeli

2020

Molec Gen & Gen Med

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Background Bladder cancer (BC) is the sixth common cancer among Iranians. Various risk factors such as smoking, body mass index, chronic infection, age, and genetic factors are associated with BC progression. Methods It has been shown that a significant ratio of patients have tumors with muscle bladder layer invasion and poor prognosis at the time of diagnosis. Therefore, the early detection of tumors is required to reduce the mortality rate of BC cases. Since there is a wide geographical incidence variation in BC in Iran, it seems that the ethnic and genetic factors can be the main risk factors among Iranian BC patients. Results For the first time, in present review we have summarized all of the reported genes among Iranian BC patients until now which were significantly associated with tumorigenesis. Moreover, we categorized all of the reported genes based on their cell and molecular functions to clarify the genetic and molecular biology of BC among Iranian population. Conclusion This review paves the way of determination of a population‐based genetic panel markers for the early detection of BC in this population.

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“…S1PRs exhibit overlapping or selective expression patterns in various cells and tissues: S1PR1-2 and 3 have a wide tissue distribution, whereas S1PR4 is present mainly in lymphoid tissues, and S1PR5 is expressed predominately in the nervous system. Interestingly, a shift in the content of each different S1PR subtypes has been correlated to various biological processes [55], including skeletal muscle differentiation [56] as well as cell degeneration, such as skeletal muscle cell atrophy [57].…”

Section: S1p/s1pr Signalingmentioning

confidence: 99%

Sphingosine 1-Phosphate (S1P)/ S1P Receptor Signaling and Mechanotransduction: Implications for Intrinsic Tissue Repair/Regeneration

Sassoli

Pierucci

Zecchi‐Orlandini

et al. 2019

IJMS

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Tissue damage, irrespective from the underlying etiology, destroys tissue structure and, eventually, function. In attempt to achieve a morpho-functional recover of the damaged tissue, reparative/regenerative processes start in those tissues endowed with regenerative potential, mainly mediated by activated resident stem cells. These cells reside in a specialized niche that includes different components, cells and surrounding extracellular matrix (ECM), which, reciprocally interacting with stem cells, direct their cell behavior. Evidence suggests that ECM stiffness represents an instructive signal for the activation of stem cells sensing it by various mechanosensors, able to transduce mechanical cues into gene/protein expression responses. The actin cytoskeleton network dynamic acts as key mechanotransducer of ECM signal. The identification of signaling pathways influencing stem cell mechanobiology may offer therapeutic perspectives in the regenerative medicine field. Sphingosine 1-phosphate (S1P)/S1P receptor (S1PR) signaling, acting as modulator of ECM, ECM-cytoskeleton linking proteins and cytoskeleton dynamics appears a promising candidate. This review focuses on the current knowledge on the contribution of S1P/S1PR signaling in the control of mechanotransduction in stem/progenitor cells. The potential contribution of S1P/S1PR signaling in the mechanobiology of skeletal muscle stem cells will be argued based on the intriguing findings on S1P/S1PR action in this mechanically dynamic tissue.

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Differential expression of S1P receptor subtypes in human bladder transitional cell carcinoma

Cited by 7 publications

References 26 publications

Targeting S1PR1 May Result in Enhanced Migration of Cancer Cells in Bladder Carcinoma

Targeting S1PR1 May Result in Enhanced Migration of Cancer Cells in Bladder Carcinoma

Genetic and molecular biology of bladder cancer among Iranian patients

Sphingosine 1-Phosphate (S1P)/ S1P Receptor Signaling and Mechanotransduction: Implications for Intrinsic Tissue Repair/Regeneration

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