1996
DOI: 10.1002/stem.140239
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Differential Expression of Telomerase Activity in Hematopoietic Progenitors from Adult Human Bone Marrow

Abstract: Abstract. The loss of telomeric DNA may serve as a mitotic clock which signals cell senescence and exit from cell cycle. Telomerase, an enzyme which synthesizes telomeric repeats de novo, is required to maintain telomere lengths. In humans, significant telomerase activity has been found in cells with essentially unlimited replicative potential such as reproductive cells in ovaries and testes, immortal cell lines and cancer tissues, but not in most normal somatic cells or tissues. We have now examined telomeras… Show more

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Cited by 363 publications
(232 citation statements)
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“…These results are consistent with earlier reports that BM-derived CD34 + CD38 − cells have a longer terminal restriction fragment (TRF) length than their CD34 + CD38 + counterparts, 15 and that CD34 + CD38 + committed progenitors express higher telomerase activity. 12,13,16 It is well documented that the c-kit/SCF system plays an important role in the early stage of hematopoiesis. 23,26,32,[37][38][39][40][41][42] Therefore, it is important to clarify the pattern of c-kit expression on primitive stem/progenitor cells, but there have been conflicting reports concerning this antigen on such cells.…”
Section: Discussionmentioning
confidence: 99%
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“…These results are consistent with earlier reports that BM-derived CD34 + CD38 − cells have a longer terminal restriction fragment (TRF) length than their CD34 + CD38 + counterparts, 15 and that CD34 + CD38 + committed progenitors express higher telomerase activity. 12,13,16 It is well documented that the c-kit/SCF system plays an important role in the early stage of hematopoiesis. 23,26,32,[37][38][39][40][41][42] Therefore, it is important to clarify the pattern of c-kit expression on primitive stem/progenitor cells, but there have been conflicting reports concerning this antigen on such cells.…”
Section: Discussionmentioning
confidence: 99%
“…14 Moreover, telomerase is up-regulated when cells enter the cell cycle. 12,13,16 These findings suggest that telomerase expression by hematopoietic stem/progenitor cells may correlate with their proliferative capacity.…”
Section: Introductionmentioning
confidence: 96%
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“…Bone marrow insufficiency in a telomerasedeficient disease, DKC (Vulliamy et al, 2001), may be further evidence of that. Telomerase activity appears to be upregulated in response to cytokine-induced proliferation and cell cycle activation in primitive HSCs, and progressively downregulated in more matured subsets (Chiu et al, 1996) except for mitogenically activated lymphocytes (Hiyama et al, 1995) (Figure 1). Stem cells are capable of generating a very large number of committed progenitors and their descendants during a small number of self-renewal divisions.…”
Section: Telomeres and Telomerase In Haematopoietic Stem Cellsmentioning
confidence: 99%
“…Most normal adult somatic cells are devoid of telomerase or transiently express very low levels of the enzyme. [22][23][24][25] This lack of telomerase results in progressive shortening of the telomeres and ultimately results in senescence and cell death. 26,27 The selective telomerase expression in tumor cells is largely due to transcriptional activation of the hTERT gene.…”
mentioning
confidence: 99%