Differential expression of the cerebral cortex proteome in physically trained adult rats

Anand, Santosh; Devi, S. Asha; Ravikiran, Tekupalli

doi:10.1016/j.brainresbull.2014.04.012

Cited by 9 publications

(6 citation statements)

References 20 publications

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“…In the present study, the body weight is decreased in swim-trained and supplemented groups, which indicates the beneficial effects of exercise training and supplementation of root extract. Earlier, we have reported reduction in the body weight of rats subjected to swimming training at 3 % intensity for 30 days [31]. Studies by Bais et al and Boque et al reported that supplementation with plant extract polyphenols decreased body weight gain in obese rats [32,33].…”

Section: Discussionmentioning

confidence: 99%

Age-related changes in the brain antioxidant status: modulation by dietary supplementation of Decalepis hamiltonii and physical exercise

et al. 2016

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The synergistic effects of physical exercise and diet have profound benefits on brain function. The present study was aimed to determine the effects of exercise and Decalepis hamiltonii (Dh) on age-related responses on the antioxidant status in discrete regions of rat brain. Male Wistar albino rats of 4 and 18 months old were orally supplemented with Dh extract and swim trained at 3 % intensity for 30 min/day, 5 days/ week, for a period of 30 days. Supplementation of 100 mg Dh aqueous extract/kg body weight and its combination with exercise significantly elevated the antioxidant enzyme activities irrespective of age. Age-related and region-specific changes were observed in superoxide levels, and protein carbonyl and malondialdehyde contents, and were found to be decreased in both trained and supplemented groups. Levels of total thiols, protein, and nonprotein thiols decreased with age and significantly increased in the SW-T(?100 mg) groups. Our results demonstrated that the interactive effects of two treatments enhanced the antioxidant status and decreased the risk of protein and lipid oxidation in the rat brain.

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Section: Discussionmentioning

confidence: 99%

Age-related changes in the brain antioxidant status: modulation by dietary supplementation of Decalepis hamiltonii and physical exercise

et al. 2016

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“…Our results showed that the expression of KRT8, PCBD1, KRT18, PRDX1, and ACY1A increased along with swimming time. Ding et al reported elevated KRT18 expression in the rat hippocampus following treadmill exercise . According to proteomic analyses, cytoskeletal formation were up‐regulated in the heart following swimming exercise .…”

Section: Discussionmentioning

confidence: 99%

“…Ding et al 20 reported elevated KRT18 expression in the rat hippocampus following treadmill exercise. 17 According to proteomic analyses, cytoskeletal formation were up-regulated in the heart following swimming exercise. 27 Interestingly, we found evidence of both up-regulation and down-regulation of KRT8 (spots 29 and 19, respectively).…”

Section: Three Kinds Of Differentially Expressed Proteinsmentioning

confidence: 99%

“…The application of proteomics technology in sports science enables better understanding of changes in protein expression and their potential roles in fatigue, and thus makes it possible to identify biomarkers that may indicate athletic fatigue. During exercise, different modes, intensity, and the environment may impact on protein expression in the blood, kidney, muscle, heart, and brain . During the course of training, mild or deep fatigue may appear, and protein expression will be altered, not only on the cell membrane, but also in intracellular and extracellular regions.…”

Section: Introductionmentioning

confidence: 99%

“…During exercise, different modes, intensity, and the environment may impact on protein expression in the blood, 10,11 kidney, 12 muscle, 13,14 heart, 15,16 and brain. 17 During the course of training, mild or deep fatigue may appear, and protein expression will be altered, not only on the cell membrane, but also in intracellular and extracellular regions.…”

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Proteomic response of the rat liver in differential swimming modes

Chen

Yang

Wang

et al. 2018

Clin Exp Pharma Physio

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Moderate exercise helps improve competition results, providing a balanced muscle tone and biochemical activity, whereas excessive training disrupts the balance between training and recovery, causes harm to the organism, and leads to overtraining syndrome (OTS). To explore the mechanisms of different protein expressions during training and acquisition of immunity, we used proteomic analyses to investigate the differences of liver-protein expressions between 2 swimming modes. Sprague-Dawley rats were randomly divided into control (CT), fatigue training (FT), and exhaustive training (ET) groups, and liver tissues from each group were subjected to 2-dimensional electrophoresis (2DE). A total of 4518 protein spots were detected in 9 replicates, and 45 protein spots exhibited a >2-fold difference in expression (P < .05), 31 of which was successfully identified by mass spectrometry. SERPINA3K expression decreased markedly during 2 stages from CT → FT and FT → ET, while DDT, RHOT1, and RBP4 decreased significantly only from CT → ET but not from the former 2 stages. By contrast, KRT8, PCBD1, KRT18, PRDX1, and ACY1A showed significant >2-fold increase in expression in either the CT → FT or FT → ET stages. Bioinformatic analyses showed that among the identified proteins, 30.2%, 54.18%, and 15.62% were involved in biological processes, molecular functions, and cell composition, respectively. Notably, PCBD1, PRDX1, and PPP1CB were involved in redox processes, while PPP1CB was only expressed in the FT group. RGN, PSMB9, and AGT, commonly recognized as oxidative stress biomarkers, may involve in regulating homeostasis in the locomotor mode and may provide diagnostic criteria for the occurrence and prevention of exercise-induced fatigue and OTS.

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Disturbances in Redox Homeostasis in the Ageing Brain

Devi

Basavaraju

2021

Healthy Ageing and Longevity

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Differential expression of the cerebral cortex proteome in physically trained adult rats

Cited by 9 publications

References 20 publications

Age-related changes in the brain antioxidant status: modulation by dietary supplementation of Decalepis hamiltonii and physical exercise

Age-related changes in the brain antioxidant status: modulation by dietary supplementation of Decalepis hamiltonii and physical exercise

Proteomic response of the rat liver in differential swimming modes

Disturbances in Redox Homeostasis in the Ageing Brain

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